Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nina E. de Groot"'
Autor:
Rana Ramadan, Valérie M. Wouters, Sanne M. van Neerven, Nina E. de Groot, Tania Martins Garcia, Vanessa Muncan, Olivia D. Franklin, Michelle Battle, Karen Sue Carlson, Joshua Leach, Owen J. Sansom, Olivier Boulard, Mathias Chamaillard, Louis Vermeulen, Jan Paul Medema, David J. Huels
Publikováno v:
Biology Open, Vol 11, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/ee689493b87c437690668170fbf2c3b2
Autor:
Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mutation leading to such
Externí odkaz:
https://doaj.org/article/eadd93dc5c0b4df5ab1fbd8979ed785d
Autor:
Job Komen, Sanne M. van Neerven, Elsbeth G. B. M. Bossink, Nina E. de Groot, Lisanne E. Nijman, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer
Publikováno v:
Micromachines, Vol 13, Iss 5, p 739 (2022)
The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, and the impe
Externí odkaz:
https://doaj.org/article/18db37a0126c41348682c3579ba25ad1
Autor:
Sanne M van Neerven, Wouter L Smit, Milou S van Driel, Vaishali Kakkar, Nina E de Groot, Lisanne E Nijman, Clara C Elbers, Nicolas Léveillé, Jarom Heijmans, Louis Vermeulen
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-16 (2022)
Abstract The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a
Externí odkaz:
https://doaj.org/article/891ee3363d044458ba63925b9b465371
Autor:
Maarten M G van den Hoogenhof, Ingeborg van der Made, Abdelaziz Beqqali, Nina E de Groot, Amin Damanafshan, Ralph J van Oort, Yigal M Pinto, Esther E Creemers
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0184093 (2017)
The importance of tightly controlled alternative pre-mRNA splicing in the heart is emerging. The RNA binding protein Rbm24 has recently been identified as a pivotal cardiac splice factor, which governs sarcomerogenesis in the heart by controlling the
Externí odkaz:
https://doaj.org/article/849c6d7da6ec4f1da3aa0ca187ca4e67
Autor:
Erik van Dijk, Jan Paul Medema, Bauke Ylstra, Daniël M. Miedema, Kristiaan J. Lenos, Veronique L. Veenstra, Lisanne E. Nijman, Maartje van der Heijden, Sanne M. van Neerven, Nina E. de Groot, Martin A. Nowak, Douglas J. Winton, Andrea Arricibita Varea, Bartlomiej Waclaw, Edward Morrissey, Maarten F. Bijlsma, Maria C. Lecca, Pramudita R. Prasetyanti, Sophie C. Lodestijn, Louis Vermeulen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 116(13), 6140-6145. National Academy of Sciences
van der Heijden, M, Miedema, D, Waclaw, B, Veenstra, V, Lecca, M, Nijman, L, Dijk, E, van Neerven, S, Lodestijn, S, Lenos, K, de Groot, N, Prasetyanti, P, Arricibita Varea, A, Winton, D, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M, Bijlsma, M & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
van der Heijden, M, Miedema, D M, Waclaw, B, Veenstra, V L, Lecca, M C, Nijman, L E, van Dijk, E, van Neerven, S M, Lodestijn, S C, Lenos, K J, de Groot, N E, Prasetyanti, P R, Varea, A A, Winton, D J, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M A, Bijlsma, M F & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
van der Heijden, M, Miedema, D, Waclaw, B, Veenstra, V, Lecca, M, Nijman, L, Dijk, E, van Neerven, S, Lodestijn, S, Lenos, K, de Groot, N, Prasetyanti, P, Arricibita Varea, A, Winton, D, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M, Bijlsma, M & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
van der Heijden, M, Miedema, D M, Waclaw, B, Veenstra, V L, Lecca, M C, Nijman, L E, van Dijk, E, van Neerven, S M, Lodestijn, S C, Lenos, K J, de Groot, N E, Prasetyanti, P R, Varea, A A, Winton, D J, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M A, Bijlsma, M F & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
Significance Colorectal cancer (CRC) is a heterogeneous disease, with significant variation in genotype and phenotype within each individual tumor. This intratumor heterogeneity emerges during tumor development due to clonal evolution and in part can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3067c66ea779680d543b2321a5015fc
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063961772&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063961772&origin=inward
Autor:
Edward Morrissey, Leandro F. Moreno, Vaishali Kakkar, Maria C. Lecca, Douglas J. Winton, Przemek M. Krawczyk, Prashanthi Ramesh, Jan Paul Medema, Louis Vermeulen, Arthur S. Aelvoet, Daniël O. Warmerdam, Nina E. de Groot, Milou S. van Driel, Lisanne E. Nijman, Jan Koster, Nicolas Léveillé, Evelien Dekker, Sanne ten Hoorn, Felipe A. Vieira Braga, Sanne M. van Neerven, Lianne Koens, Marouska F. van Boxel, Maarten F. Bijlsma, Delano R. Sanches, Brendon P. Scicluna
Publikováno v:
Nature
Nature, 594(7863), 436-441. Nature Publishing Group
Nature, 594(7863), 436-441. Nature Publishing Group
A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the gut lining. Disruption of this balance by mutations in the tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa823e300aa04c0d10dea937321075
Autor:
Salvatore Simmini, Nicolas Léveillé, Ronja S. Adam, Andrew N Holding, Cayetano Pleguezuelos-Manzano, Nina E. de Groot, Florian Markowetz, Sanne M. van Neerven, Louis Vermeulen
Publikováno v:
Cancer Cell International, 20(1):578. BioMed Central Ltd.
Cancer Cell International
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Cancer Cell International
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
BackgroundCancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mutation leading to such features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a05f757dc531c746bee4cb16993e67
https://pure.amc.nl/en/publications/intestinal-regionspecific-wnt-signalling-profiles-reveal-interrelation-between-cell-identity-and-oncogenic-pathway-activity-in-cancer-development(6f835627-126e-47fa-a987-a50fc63462e0).html
https://pure.amc.nl/en/publications/intestinal-regionspecific-wnt-signalling-profiles-reveal-interrelation-between-cell-identity-and-oncogenic-pathway-activity-in-cancer-development(6f835627-126e-47fa-a987-a50fc63462e0).html
Autor:
Ingeborg van der Made, Esther E. Creemers, Amin Damanafshan, Yigal M. Pinto, Shirley C. M. van Amersfoorth, Maarten M.G. van den Hoogenhof, Mauro Giacca, Nina E. de Groot, Lorena Zentilin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
van den Hoogenhof, M M G, van der Made, I, de Groot, N E, Damanafshan, A, van Amersfoorth, S C M, Zentilin, L, Giacca, M, Pinto, Y M & Creemers, E E 2018, ' AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart ', Scientific Reports, vol. 8, no. 1, 11696 . https://doi.org/10.1038/s41598-018-29552-x
Scientific Reports
Scientific reports, 8(1):11696. Nature Publishing Group
van den Hoogenhof, M M G, van der Made, I, de Groot, N E, Damanafshan, A, van Amersfoorth, S C M, Zentilin, L, Giacca, M, Pinto, Y M & Creemers, E E 2018, ' AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart ', Scientific Reports, vol. 8, no. 1, 11696 . https://doi.org/10.1038/s41598-018-29552-x
Scientific Reports
Scientific reports, 8(1):11696. Nature Publishing Group
The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac development by governing a large number of muscle-specific splicing events. Since Rbm24 knockout m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633138c5bc8fd11f87448404d8c076c
https://doi.org/10.1038/s41598-018-29552-x
https://doi.org/10.1038/s41598-018-29552-x
Autor:
Harmen J.G. van de Werken, Vincent M. Christoffels, Nina E. de Groot, Jan M. Ruijter, Irina A. Sergeeva, Ingeborg B. Hooijkaas, Esther E. Creemers, Ingeborg van der Made
Publikováno v:
Development, 143(12), 2135-2146. Company of Biologists Ltd
Development (Cambridge, England), 143(12), 2135-2146. Company of Biologists Ltd
Development (Cambridge, England), 143(12), 2135-2146. Company of Biologists Ltd
The paralogous genes Nppa and Nppb are organized in an evolutionary conserved cluster and are a valuable model to study coregulation and regulatory landscape organization during heart development and disease. Here, we analyzed the chromatin conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1000af7742ca9443fc3386f35023db
https://pure.eur.nl/en/publications/ef2bf119-99de-4464-819b-138e92f5875d
https://pure.eur.nl/en/publications/ef2bf119-99de-4464-819b-138e92f5875d