Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nina E. Ottosson"'
Autor:
Nina E, Ottosson, Malin, Silverå Ejneby, Xiongyu, Wu, Argel, Estrada-Mondragón, Michelle, Nilsson, Urban, Karlsson, Melanie, Schupp, Salomé, Rognant, Thomas Andrew, Jepps, Peter, Konradsson, Fredrik, Elinder
Publikováno v:
EpilepsiaREFERENCES. 62(7)
About one third of all patients with epilepsy have pharmacoresistant seizures. Thus there is a need for better pharmacological treatments. The human voltage-gated potassium (hKIon channels were expressed in Xenopus oocytes or mammalian cell lines and
Autor:
Peter Konradsson, Michelle Nilsson, Malin Silverå Ejneby, Xiongyu Wu, Thomas A. Jepps, Urban Karlsson, Argel Estrada-Mondragón, Fredrik Elinder, Salomé Rognant, Melanie Schupp, Nina E. Ottosson
Publikováno v:
Ottosson, N E, Ejneby, M S, Wu, X, Estrada-Mondragon, A, Nilsson, M, Karlsson, U, Schupp, M, Rognant, S, Jepps, T A, Konradsson, P & Elinder, F 2021, ' Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures ', Epilepsia, vol. 62, no. 7, pp. 1744-1758 . https://doi.org/10.1111/epi.16932
Objective About one third of all patients with epilepsy have pharmacoresistant seizures. Thus there is a need for better pharmacological treatments. The human voltage-gated potassium (hK(V)) channel hK(V)7.2/7.3 is a validated antiseizure target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b80e815713c1101190996e21db2cc8
https://curis.ku.dk/ws/files/272246120/Synthetic_resin_acid_derivatives_selectively_open.pdf
https://curis.ku.dk/ws/files/272246120/Synthetic_resin_acid_derivatives_selectively_open.pdf
Autor:
Nina E. Ottosson, Fredrik Elinder
Publikováno v:
Biophysical Journal. 121:238a
Autor:
Arina Gromova, Malin Silverå Ejneby, Argel Estrada-Mondragón, Nina E. Ottosson, Samira Yazdi, Stina Borg, Fredrik Elinder, Lucie Delemotte, Panagiotis Apostolakis
Voltage-gated potassium (KV) channels can be opened by negatively charged resin acids and their derivatives. These resin acids have been proposed to attract the positively charged voltage-sensor helix (S4) toward the extracellular side of the membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eab08cc648615e0a0ebedfa946cf4908
https://doi.org/10.1101/2020.06.11.146548
https://doi.org/10.1101/2020.06.11.146548
Autor:
Malin, Silverå Ejneby, Arina, Gromova, Nina E, Ottosson, Stina, Borg, Argel, Estrada-Mondragón, Samira, Yazdi, Panagiotis, Apostolakis, Fredrik, Elinder, Lucie, Delemotte
Publikováno v:
The Journal of General Physiology
Silverå Ejneby et al. use molecular dynamics simulations and electrophysiology to show that the voltage-gated Shaker potassium channel has multiple binding sites for resin-acid derivatives that can regulate its opening.
Voltage-gated potassium
Voltage-gated potassium
Publikováno v:
European Journal of Organic Chemistry. 2018:1730-1734
A Suzuki-Miyaura coupling reaction of ortho-hydroxy-aromatic bromide 8 with isopropenylboronic acid pinacol ester has been investigated. It was found that the catalyst of Pd-2(dba)(3)/PCy3 in dioxa ...
Autor:
Malin Silverå Ejneby, E. Peter Münger, Peter Konradsson, Fredrik Elinder, Xiongyu Wu, Nina E. Ottosson, Ingemar Lundström
Publikováno v:
The Journal of General Physiology
Dehydroabietic acid was recently shown to open voltage-gated potassium channels. Silverå Ejneby et al. show that its effect peaks when the carboxyl-group charge and hydrophobic anchor are separated by three atoms and use this rule to design molecule
Autor:
Xiongyu Wu, Fredrik Elinder, Malin Silverå Ejneby, Melanie Schupp, Peter Konradsson, Nina E. Ottosson, Urban Karlsson, Michelle Nilsson
Publikováno v:
Biophysical Journal. 118:264a-265a
Publikováno v:
Biophysical Journal. 118:112a
Autor:
Nina E. Ottosson
Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f2232a3e4f8cb3ef0a94c2b1d77df7
https://doi.org/10.3384/diss.diva-136686
https://doi.org/10.3384/diss.diva-136686