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Akademický článek

Liver Bacterial Dysbiosis With Non-Tuberculosis Mycobacteria Occurs in SIV-Infected Macaques and Persists During Antiretroviral Therapy

Autor: Bridget S. Fisher, Katherine A. Fancher, Andrew T. Gustin, Cole Fisher, Matthew P. Wood, Michael Gale, Benjamin J. Burwitz, Jeremy Smedley, Nichole R. Klatt, Nina Derby, Donald L. Sodora

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Liver disease is a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful viral suppression with combination antiretroviral therapy (cART). Similar to HIV infection, SIV infection of rhesus macaques is

Externí odkaz: https://doaj.org/article/d73c35822bd84408890f4f50ab8f6716

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Akademický článek

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving

Externí odkaz: https://doaj.org/article/8d4f42eeb266482fa22316c03e392e44

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Akademický článek

Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques

Autor: Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, Nina Derby

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Herpes simplex virus 1 and 2 (HSV-1/2) similarly initiate infection in mucosal epithelia and establish lifelong neuronal latency. Anogenital HSV-2 infection augments the risk for sexual human immunodeficiency virus (HIV) transmission and is associate

Externí odkaz: https://doaj.org/article/1f673356d51b44bbb4efd3d67140f2ad

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Akademický článek

Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination.

Autor: Natalia Guerra-Pérez, Meropi Aravantinou, Filippo Veglia, Diana Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, Elena Martinelli

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149491 (2016)

Prevalent HSV-2 infection increases the risk of HIV acquisition both in men and women even in asymptomatic subjects. Understanding the impact of HSV-2 on the mucosal microenvironment may help to identify determinants of susceptibility to HIV. Vaginal

Externí odkaz: https://doaj.org/article/3346cfefab224f0fbd8ca3306f113b26

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Akademický článek

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo.

Autor: Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres Salazar, Michael Piatak, Jeffrey D Lifson, Melissa Robbiani, Nina Derby

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0161730 (2016)

Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-str

Externí odkaz: https://doaj.org/article/4431bc835c684b81878ea77df9d8e4e0

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Akademický článek

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89300 (2014)

When microbicides used for HIV prevention contain antiretroviral drugs, there is concern for the potential emergence of drug-resistant HIV following use in infected individuals who are either unaware of their HIV infection status or who are aware but

Externí odkaz: https://doaj.org/article/b1f84d839f2a4832b1c088e64864c11d

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Akademický článek

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV.

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94547 (2014)

Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) ma

Externí odkaz: https://doaj.org/article/9f20173b1dae4edd8e9a6f19a6dbcc8a

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Akademický článek

Sex hormones selectively impact the endocervical mucosal microenvironment: implications for HIV transmission.

Autor: Diana Goode, Meropi Aravantinou, Sebastian Jarl, Rosaline Truong, Nina Derby, Natalia Guerra-Perez, Jessica Kenney, James Blanchard, Agegnehu Gettie, Melissa Robbiani, Elena Martinelli

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97767 (2014)

Several studies suggest that progesterone and estrogens may affect HIV transmission in different, possibly opposing ways. Nonetheless, a direct comparison of their effects on the mucosal immune system has never been done. We hypothesize that sex horm

Externí odkaz: https://doaj.org/article/5a9d01f595154065b64288750cc8e4ca

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