A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism

Autor: Margaret R. MacLean, Divya Pandya, Emilia M. Swietlik, Nina Denver, Kirsty Mair, Nicholas W. Morrell, Stefan Gräf, National Cohort Study for Idiopathic and Heritable Pulmonary Arterial Hypertension Consortium

Publikováno v: Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)

Abstract The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for

Externí odkaz: https://doaj.org/article/dec4cb90876246eabc4530ead367a981

Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension

Autor: Nina Denver, Natalie Z.M. Homer, Ruth Andrew, Katie Y. Harvey, Nicholas Morrell, Eric D. Austin, Margaret R. MacLean

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic me

Externí odkaz: https://doaj.org/article/59a9d1e549ce4bb4a4d9563178b30633

Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2)

Autor: Ruth Andrew, Nadine Al-Naamani, Kari E. Roberts, Kimberly A. Forde, Gustavo A. Heresi, Todd M. Bull, Karen L. Krok, Margaret R. MacLean, Anna R. Hemnes, Sonja Bartolome, Nina Denver, Michael J. Krowka, Jae K. Oh, Michael B. Fallon, Rui Feng, Raed A. Dweik, Margaret F. Doyle, Mamta J. Patel, Steven M. Kawut, Grace Lin, Eric D. Austin

Publikováno v: Hepatology
Al-Naamani, N, Krowka, M J, Forde, K A, Krok, K L, Feng, R, Heresi, G A, Dweik, R A, Bartolome, S, Bull, T M, Roberts, K E, Austin, E D, Hemnes, A R, Patel, M J, Oh, J K, Lin, G, Doyle, M F, Denver, N, Andrew, R, MacLean, M R, Fallon, M B & Kawut, S M 2020, ' Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2) ', Hepatology . https://doi.org/10.1002/hep.31314

Background and Aims: Portopulmonary hypertension (POPH) was previously associated with a single-nucleotide polymorphism (SNP) rs7175922 in aromatase (cytochrome P450 family 19 subfamily A member 1 [CYP19A1]). We sought to determine whether genetic va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eafa2dbd5014935eba6faea0d12c557
https://doi.org/10.1002/hep.31314

Sex Differences in Pulmonary Hypertension

Autor: Kirsty M. Mair, Nina Denver, Rosemary Gaw, Hicham Labazi, Margaret R. MacLean, Hannah Morris

Publikováno v: Clinics in chest medicine. 42(1)

Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f7a9a8446bc5ab65b24657d1440206
https://pubmed.ncbi.nlm.nih.gov/33541615

Direct delivery of microRNA96 to the lungs reduces progression of sugen/hypoxia-induced pulmonary hypertension in the rat

Autor: Margaret R. MacLean, Nina Denver, Rebecca L. Openshaw, Dianne Z. Hillyard, Craig K. Docherty, Margaret Nilsen, Hicham Labazi, Simon Fisher

Publikováno v: Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 396-405 (2020)

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49af2e82db7d961eb98cef09cf0c51a
https://strathprints.strath.ac.uk/75323/1/Docherty_etal_MTNA_2020_Direct_delivery_of_microRNA96_to_the_lungs_reduces_progression.pdf