Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Nina C Weber"'
Autor:
Sha Chen, Kenneth Overberg, Zakiya Ghouse, Markus W. Hollmann, Nina C. Weber, Ruben Coronel, Coert J. Zuurbier
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116477- (2024)
Background: SGLT2i reduce cardiac hypertrophy, but underlying mechanisms remain unknown. Here we explore a role for serine/threonine kinases (STK) and sodium hydrogen exchanger 1(NHE1) activities in SGLT2i effects on cardiac hypertrophy. Methods: Iso
Externí odkaz:
https://doaj.org/article/66c45ad5380a457c848948bdb50a2688
Autor:
Daan P. van den Brink, Derek J. B. Kleinveld, Annabel Bongers, Jaël Vos, Joris J. T. H. Roelofs, Nina C. Weber, Jaap D. van Buul, Nicole P. Juffermans
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-9 (2023)
Abstract Background Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either to low protein conten
Externí odkaz:
https://doaj.org/article/2e71c8bb73db4b7498d7cd7a174e6bfb
Autor:
Raoul A. Fakkert, Noa Karlas, Patrick Schober, Nina C. Weber, Benedikt Preckel, Robert A. van Hulst, Robert P. Weenink
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-7 (2023)
Abstract Background Iatrogenic cerebral arterial gas embolism (CAGE) caused by invasive medical procedures may be treated with hyperbaric oxygen therapy (HBOT). Previous studies suggested that initiation of HBOT within 6–8 h is associated with high
Externí odkaz:
https://doaj.org/article/792c03fd9cc941198ee3c9afbf864ae0
Autor:
Xiaoling Li, Mengnan Wang, Jan-Ole Kalina, Benedikt Preckel, Markus W. Hollmann, Martin Albrecht, Coert J. Zuurbier, Nina C. Weber
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 102979- (2024)
Background: Empagliflozin (EMPA) ameliorates reactive oxygen species (ROS) generation in human endothelial cells (ECs) exposed to 10 % stretch, but the underlying mechanisms are still unclear. Pathological stretch is supposed to stimulate protein kin
Externí odkaz:
https://doaj.org/article/2f33de2efafb4ef0b4548402cf79295b
Autor:
Xiaoling Li, Raphaela P. Kerindongo, Benedikt Preckel, Jan-Ole Kalina, Markus W. Hollmann, Coert J. Zuurbier, Nina C. Weber
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114228- (2023)
Background: Canagliflozin (CANA) shows anti-inflammatory and anti-oxidative effects on endothelial cells (ECs). In diabetes mellitus (DM), excessive reactive oxygen species (ROS) generation, increased intracellular calcium (Ca2+) and enhanced extrace
Externí odkaz:
https://doaj.org/article/d73cc82c10a8419f99317442d2fbd5da
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Sodium-glucose-cotransporter 2 inhibitors (SGLT2is) demonstrate large cardiovascular benefit in both diabetic and non-diabetic, acute and chronic heart failure patients. These inhibitors have on-target (SGLT2 inhibition in the kidney) and of
Externí odkaz:
https://doaj.org/article/3ea4326ec125483fa86d94129c64fd5f
Autor:
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Publikováno v:
Cells, Vol 12, Iss 10, p 1432 (2023)
Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap remains between experimental findings and clinical practice. This review provi
Externí odkaz:
https://doaj.org/article/7c2f903cb2d14ff5aa142cd8e9b5eddb
Autor:
Laween Uthman, Xiaoling Li, Antonius Baartscheer, Cees A. Schumacher, Patricia Baumgart, Jeroen Hermanides, Benedikt Preckel, Markus W. Hollmann, Ruben Coronel, Coert J. Zuurbier, Nina C. Weber
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112515- (2022)
Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i’s) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflamma
Externí odkaz:
https://doaj.org/article/714ef2cb2d7f40598704c5380f100e1b
Autor:
Nina C. Weber, Benedikt Preckel
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble gas helium is used in treatment
Externí odkaz:
https://doaj.org/article/d26ca6a4b6a940b39565aaea2219a0f6
Autor:
Laween Uthman, Anna Homayr, Rio P. Juni, Eva L. Spin, Raphaela Kerindongo, Marleen Boomsma, Markus W. Hollmann, Benedikt Preckel, Pieter Koolwijk, Victor W.M. van Hinsbergh, Coert J. Zuurbier, Martin Albrecht, Nina C. Weber
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 5, Pp 865-886 (2019)
Externí odkaz:
https://doaj.org/article/233c649f9b894beab1e1f03e1375d2bb