Výsledky vyhledávání - "Nina Blatter"

Specific Incorporation of an Artificial Nucleotide Opposite a Mutagenic DNA Adduct by a DNA Polymerase

Autor: Ursina Suter, Arman Nilforoushan, Fritz Eichenseher, Shana J. Sturla, Laura A. Wyss, Andreas Marx, Nina Blatter

Publikováno v: Journal of the American Chemical Society. 137:30-33

The ability to detect DNA modification sites at single base resolution could significantly advance studies regarding DNA adduct levels, which are extremely difficult to determine. Artificial nucleotides that are specifically incorporated opposite a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff87a5b2a93ca2f25bc916e9e85e34f
https://doi.org/10.1021/ja5100542

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Struktur und Funktion einer RNA-lesenden thermostabilen DNA-Polymerase

Autor: Nina Blatter, Oliver Nolte, Konrad Bergen, Markus Wieland, Andreas Marx, Kay Diederichs, Jutta Mayer, Wolfram Welte

Publikováno v: Angewandte Chemie. 125:12154-12158

„Untreu“: Eine DNA-abhängige DNA-Polymerase, deren Wildtyp-Vorläufer keine signifikante Reverse-Transkriptase-Aktivität zeigte, wurde beim Einbau eines Nukleotids gegenüber einem RNA-Templat abgefangen und erstmals strukturell charakterisiert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da53c311ca9b776193ac510443e28ff9
https://doi.org/10.1002/ange.201306655

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Modulating the pKaof a Tyrosine inKlenTaqDNA Polymerase that Is Crucial for Abasic Site Bypass by in Vivo Incorporation of a Non-canonical Amino Acid

Autor: Alexander Prokup, Andreas Marx, Alexander Deiters, Nina Blatter

Publikováno v: ChemBioChem. 15:1735-1737

It is estimated that about 10,000 abasic sites are formed per day per cell. Abasic sites impose a significant challenge for bypass synthesis by DNA polymerases. Recently, a tyrosine in KlenTaq DNA polymerase has been highlighted as being crucial for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d5fbc686d4a116e93ea959d084bc5a
https://doi.org/10.1002/cbic.201400051

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Replication through an abasic DNA lesion: structural basis for adenine selectivity

Autor: Andreas Marx, Kay Diederichs, Andreas Schnur, Wolfram Welte, Samra Obeid, Nina Blatter, Ramon Kranaster

Publikováno v: The EMBO Journal. 29:1738-1747

Abasic sites represent the most frequent DNA lesions in the genome that have high mutagenic potential and lead to mutations commonly found in human cancers. Although these lesions are devoid of the genetic information, adenine is most efficiently ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8347d7a622af999801a5e66cb2039f58
https://doi.org/10.1038/emboj.2010.64

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Structure and Function of an RNA-Reading Thermostable DNA Polymerase

Autor: Kay Diederichs, Konrad Bergen, Oliver Nolte, Markus Wieland, Andreas Marx, Nina Blatter, Jutta Mayer, Wolfram Welte

Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally character

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Lost in replication: DNA polymerases encountering non-instructive DNA lesions

Autor: Samra Obeid, Andreas Marx, Nina Blatter

Publikováno v: Collection Symposium Series.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::575887b86164e940334db1cf8214ab56
https://doi.org/10.1135/css201112027

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Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity

Autor: Nina Blatter, Kay Diederichs, Christian Gloeckner, Andreas Marx, Wolfram Welte, Samra Obeid, Andreas Schnur

Publikováno v: Chembiochem : a European journal of chemical biology. 12(10)

DNA is being constantly damaged by endo- and exogenous agents such as reactive oxygen species, chemicals, radioactivity, and ultraviolet radiation. Additionally, DNA is inherently labile, and this can result in, for example, the spontaneous hydrolysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33401db50b6b876cf237345a77935a67
https://pubmed.ncbi.nlm.nih.gov/21480455

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Cover Picture: Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity (ChemBioChem 10/2011)

Autor: Wolfram Welte, Samra Obeid, Christian Gloeckner, Andreas Marx, Nina Blatter, Kay Diederichs, Andreas Schnur

Publikováno v: ChemBioChem. 12:1437-1437

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ebe71092f95ff2d1ffaff1f12f455d
https://doi.org/10.1002/cbic.201190043

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