Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nina Balthasar"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153187 (2016)
Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as cardiorespiratory depression. These drugs mimic peptides such as β-endorphin, which has a key role in en
Externí odkaz:
https://doaj.org/article/bc20dff7fb0c4a5591035b9bb61af3fc
Autor:
Heather J M Weir, Tracey K Murray, Patrick G Kehoe, Seth Love, Eric M Verdin, Michael J O'Neill, Jon D Lane, Nina Balthasar
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48225 (2012)
Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial resp
Externí odkaz:
https://doaj.org/article/f03a45c6fa9c44eba04d3839a9075dfd
Autor:
Michael J Higley, Aryn H Gittis, Ian A Oldenburg, Nina Balthasar, Rebecca P Seal, Robert H Edwards, Bradford B Lowell, Anatol C Kreitzer, Bernardo L Sabatini
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19155 (2011)
The neurotransmitter glutamate is released by excitatory projection neurons throughout the brain. However, non-glutamatergic cells, including cholinergic and monoaminergic neurons, express markers that suggest that they are also capable of vesicular
Externí odkaz:
https://doaj.org/article/591c8c256d984b5dacf6c07019d9f283
Autor:
Jennifer S. Steger, Nina Balthasar, Michael J. Krashes, Monica M. Li, Jon M. Resch, Joseph C. Madara, Bradford B. Lowell, John N. Campbell, Nicholas J. Conley, Alastair S. Garfield
Publikováno v:
Neuron. 102(3)
SIM1-expressing paraventricular hypothalamus (PVH) neurons are key regulators of energy balance. Within the PVHSIM1 population, melanocortin-4 receptor-expressing (PVHMC4R) neurons are known to regulate satiety and bodyweight, yet they account for on
Autor:
Li F. Chan, Nynke R. Oosterhuis, Amandine Mullier, Nuria Maicas, Tatiana V. Novoselova, Paul D. Taylor, Anne-Maj Samuelsson, Jaap A. Joles, Sung Eun Bae, Clive W. Coen, Nina Balthasar, Lucilla Poston, Joaquim Pombo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 113(43), 12298
Melanocortin-4 receptor (Mc4r)-expressing neurons in the autonomic nervous system, particularly in the paraventricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control. Mc4r-deficient (Mc4rKO) mice are severely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7a818f9ccaa71367a92f45b0839e22
https://dspace.library.uu.nl/handle/1874/343960
https://dspace.library.uu.nl/handle/1874/343960
Publikováno v:
Genes & Cancer. 4:118-124
SIRT3 is a NAD(+)-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses
Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons
Autor:
Eric D. Berglund, Louise E. Harris, Nina Balthasar, Linh Vong, Bradford B. Lowell, Kevin W. Williams, Joel K. Elmquist, Jong Woo Sohn, Tiemin Liu
Publikováno v:
Sohn, J-W, Harris, L E, Berglund, E D, Liu, T, Vong, L, Lowell, B B, Balthasar, N, Williams, K W & Elmquist, J K 2013, ' Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons ', Cell, vol. 152, no. 3, pp. 612-619 . https://doi.org/10.1016/j.cell.2012.12.022
SummaryMelanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R mutations are hyperinsulinemic and resistant to obesity-induced hypertension. Although these
Autor:
Nina Balthasar
Publikováno v:
Essential Guide to Reading Biomedical Papers: Recognising and Interpreting Best Practice
Autor:
Danielle A. Lauzon, Jason G. Anderson, Yong Xu, Juli E. Jones, Lora K. Heisler, Nina Balthasar, Bradford B. Lowell, Andrew R. Zinn, Joel K. Elmquist
Publikováno v:
The Journal of Neuroscience. 30:14630-14634
d-Fenfluramine (d-Fen) increases serotonin (5-HT) content in the synaptic cleft and exerts anorexigenic effects in animals and humans. However, the neural circuits that mediate these effects are not fully identified. To address this issue, we assesse
Autor:
Nina Balthasar
Publikováno v:
Experimental Physiology. 94:857-866
Obesity, due to its associated co-morbidities, including type 2 diabetes and cardiovascular disease, is at the forefront of today's health care concerns. Our need for novel, multifaceted approaches to tackle the global increase of waistlines is urgen