GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

Autor: Nina B Johansen, Maria Ek Lie, Andrew N. Clarkson, Nils Ole Dalby, Petrine Wellendorph, Emma K. Gowing, Louise Thiesen

Publikováno v: Lie, M E, Gowing, E K, Johansen, N B, Dalby, N O, Thiesen, L, Wellendorph, P & Clarkson, A N 2019, ' GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 1, pp. 74-88 . https://doi.org/10.1177/0271678X17744123

Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits required for recovery. This stroke-induced increase in tonic inhibition is caused by impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6708d7700e6955532d036687fb4e09
https://doi.org/10.1177/0271678x17744123