Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation

Autor: Annette D. Rieg, Said Suleiman, Carolin Anker, Nina A. Bünting, Eva Verjans, Jan Spillner, Sebastian Kalverkamp, Saskia von Stillfried, Till Braunschweig, Stefan Uhlig, Christian Martin

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract Background PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the airway tone are almost unknown. We studied this issue and th

Externí odkaz: https://doaj.org/article/d5bb3f6af2ad4b74b535baf50389da6f

Levosimendan reduces segmental pulmonary vascular resistance in isolated perfused rat lungs and relaxes human pulmonary vessels.

Autor: Annette Dorothea Rieg, Said Suleiman, Nina Andrea Bünting, Eva Verjans, Jan Spillner, Heike Schnöring, Sebastian Kalverkamp, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Gereon Schälte, Stefan Uhlig, Christian Martin

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0233176 (2020)

INTRODUCTION:Levosimendan is approved for acute heart failure. Within this context, pulmonary hypertension represents a frequent co-morbidity. Hence, the effects of levosimendan on segmental pulmonary vascular resistance (PVR) are relevant. So far, t

Externí odkaz: https://doaj.org/article/d72e14e0a7a342c6a2738dc160f3d3ad

Levosimendan reduces segmental pulmonary vascular resistance in isolated perfused rat lungs and relaxes human pulmonary vessels

Autor: Stefan Uhlig, Heike Schnöring, Annette D. Rieg, Gereon Schälte, Saskia von Stillfried, Nina Andrea Bünting, Jan Spillner, Thomas Schröder, Said Suleiman, Eva Verjans, Till Braunschweig, Sebastian Kalverkamp, Christian Martin

Publikováno v: PLOS ONE 15(5), e0233176 (2020). doi:10.1371/journal.pone.0233176
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233176 (2020)

Introduction Levosimendan is approved for acute heart failure. Within this context, pulmonary hypertension represents a frequent co-morbidity. Hence, the effects of levosimendan on segmental pulmonary vascular resistance (PVR) are relevant. So far, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aad1a64283261c51fd7cfe8ce249b95
https://publications.rwth-aachen.de/record/794772

Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices

Autor: Stefan Uhlig, Heike Schnöring, Gereon Schälte, Paul W. Manley, Saskia von Stillfried, Jan Spillner, Annette D. Rieg, Till Braunschweig, Christian Cranen, Said Suleiman, Rolf Rossaint, Nina Andrea Bünting, Thomas Schröder, Christian Martin

Publikováno v: Respiratory Research
Respiratory research 20(1), 111 (2019). doi:10.1186/s12931-019-1074-2
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)

Background Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a03d3fd4c661f9a6547bd1ba36a03a9
https://pubmed.ncbi.nlm.nih.gov/31170998