Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

Autor: Marcus Ronninger, Maria Seddighzadeh, Morten Christoph Eike, Darren Plant, Nina A Daha, Beate Skinningsrud, Jane Worthington, Tore K Kvien, Rene E M Toes, Benedicte A Lie, Lars Alfredsson, Leonid Padyukov

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32861 (2012)

HLA-DRB1 shared epitope (SE) alleles are the strongest genetic determinants for autoantibody positive rheumatoid arthritis (RA). One of the key regulators in expression of HLA class II receptors is MHC class II transactivator (CIITA). A variant of th

Externí odkaz: https://doaj.org/article/8a36cd766198420392d7d345949bfe68

Research Master in Population Health Management: work in progress

Autor: Nina A. Daha, Marc A. Bruijnzeels, Jeroen N. Struijs, Mattijs E. Numans

Publikováno v: International Journal of Integrated Care; Vol 18: Annual Conference Supplement 2018; 394

Background: Costs of health care are rising, we enter the era of multimorbidity and the patient experiences are more important. With the ageing of the population and increased medical and technical possibilities forecasts show that resources for heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa550c4ef5e8d0c1d2119fff22b03ffe
https://www.ijic.org/jms/article/view/4621

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

Autor: Tore Saxne, M. K. Leijsma, Elisabet Lindqvist, Elisabeth Brouwer, Lude Franke, M. P. M. van der Linden, D. P. C. de Rooy, T. W. J. Huizinga, René E. M. Toes, Rachel Knevel, Nina A. Daha, Jeanine J. Houwing-Duistermaat, A. Krabben, A.H.M. van der Helm-van Mil, Harm-Jan Westra, Alexandra Zhernakova, S. Tsonaka, Anthony G. Wilson

Publikováno v: ARTHRITIS AND RHEUMATISM, 65(3), 582-589. John Wiley and Sons Inc.
Arthritis & Rheumatism; Vol 65
Arthritis and Rheumatism, 65(3), 582-589
Arthritis & Rheumatism

Objective Genetic factors account for an estimated 4558% of the variance in joint destruction in rheumatoid arthritis (RA). The serine proteinase granzyme B induces target cell apoptosis, and several in vitro studies suggest that granzyme B is involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7022acf08590907d5afc4e462bf03f0
https://doi.org/10.1002/art.37808

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

Autor: Tom W J Huizinga, Anthony G. Wilson, Dominique Baeten, Annette H M van der Helm-van Mil, Tore Saxne, Elisabeth Brouwer, S. Tsonaka, René E. M. Toes, Alexandra Zhernakova, Elisabet Lindqvist, Diederik P. C. de Rooy, Nataliya Yeremenko, M. K. Leijsma, Nina A. Daha, Jeanine J. Houwing-Duistermaat, A. Krabben, Rachel Knevel

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 72(5), 769-775
Annals of the Rheumatic Diseases, 72(5), 769-775. BMJ PUBLISHING GROUP
Annals of the rheumatic diseases, 72(5), 769-775. BMJ Publishing Group
Annals of the Rheumatic Diseases; Vol 72

Background Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/beta-catenin pathway inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0be1b345c1d638b987bbe6130f24dce

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis

Autor: Xia Jiang, Henrik Källberg, Alejandro Balsa, Tore K Kvien, Paul I.W. de Bakker, Boel Brynedal, Nina A. Daha, Inge C. Olsen, Javier Gutierrez-Achury, René E. M. Toes, Bettina Kulle Andreassen, Fina A S Kurreeman, Javier Martín, Till Uhlig, Miguel A. González-Gay, Luis Rodriguez-Rodriguez, Marthe T. Maehlen, Benedicte A. Lie, Marte K. Viken, María Teruel, Lars Alfredsson, Alexandra Zhernakova

Publikováno v: Annals of the Rheumatic Diseases, 74(4), 762-768. BMJ PUBLISHING GROUP
Annals of the Rheumatic Diseases, 74(4), 762-768
Annals of the Rheumatic Diseases, 74(4), 762. BMJ Publishing Group

Objective Certain HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) are associated with rheumatoid arthritis (RA). Our objective was to examine the combined effect of these associated variants, calculated as a cumulative genetic risk score

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b455b8067bc07cd4afbdc9466b7e9e6
https://doi.org/10.1136/annrheumdis-2013-204173