Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nina Lawrence"'
Autor:
Rudolf Mueller, Virsinha Reddy, Aloysius T. Nchinda, Fanuel Mebrahtu, Dale Taylor, Nina Lawrence, Lloyd Tanner, Marine Barnabe, Charles J. Eyermann, Bin Zou, Ravinder R. Kondreddi, Suresh B. Lakshminarayana, Matthias Rottmann, Leslie J. Street, Kelly Chibale
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
Externí odkaz:
https://doaj.org/article/4ad36f674d374ec382c3bc8f6343258f
Autor:
Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 65:16695-16715
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Autor:
Ujjini H. Manjunatha, Christel Brunschwig, Mathew Njoroge, Srinivasa P. S. Rao, Nina Lawrence, Dale Taylor, Rudolf Müller, Kelly Chibale, Paul M. Njaria, Renier van der Westhuyzen, Vinayak Singh, Leslie J. Street, Amanda Mabhula, Atica Moosa, Digby F. Warner, Denis Ngumbu Muhunga, Paul W. Smith
Publikováno v:
Journal of Medicinal Chemistry. 64:9444-9457
Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime carbamate hit series. This series was subjected to medicinal chemistry progression underpinned by s
Autor:
Constance M. Korkor, Kelly Chibale, Godwin Akpeko Dziwornu, Sergio Wittlin, Dina Coertzen, Cleavon K Cloete, Meta Leshabane, Mathew Njoroge, Janette Reader, Nina Lawrence, Lyn-Marie Birkholtz, Liezl Gibhard, Mariëtte van der Watt
Publikováno v:
Journal of Medicinal Chemistry. 64:5198-5215
A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure-activity relationship studies revealed
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt
Publikováno v:
ACS Infectious Diseases. 7:34-46
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Autor:
Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson
Publikováno v:
ACS Infectious Diseases
Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol-alanine-salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized fo
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Autor:
Renier, van der Westhuyzen, Amanda, Mabhula, Paul M, Njaria, Rudolf, Müller, Denis, Ngumbu Muhunga, Dale, Taylor, Nina, Lawrence, Mathew, Njoroge, Christel, Brunschwig, Atica, Moosa, Vinayak, Singh, Srinivasa P S, Rao, Ujjini H, Manjunatha, Paul W, Smith, Digby F, Warner, Leslie J, Street, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(13)
Screening of a library of small polar molecules against