Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Nina, Possemis"'
1
Akademický článek
A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer’s disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial
Autor: Nina Possemis, Frans Verhey, Jos Prickaerts, Arjan Blokland, Inez Ramakers
Publikováno v: Trials, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Research into the neurobiological underpinnings of learning and memory has demonstrated the cognitive-enhancing effects associated with diverse classes of phosphodiesterase (PDE) inhibitors. Specific PDE inhibitors have been ident
Externí odkaz: https://doaj.org/article/cd69a97d690d460aa9bb2a284f8a4f61
Zobrazit plný text záznamu
2
Akademický článek
Validation of an Automated Speech Analysis of Cognitive Tasks within a Semiautomated Phone Assessment
Autor: Daphne ter Huurne, Nina Possemis, Leonie Banning, Angélique Gruters, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Frans Verhey, Marjolein de Vugt, Inez Ramakers
Publikováno v: Digital Biomarkers, Vol 7, Iss 1, Pp 115-123 (2023)
Introduction: We studied the accuracy of the automatic speech recognition (ASR) software by comparing ASR scores with manual scores from a verbal learning test (VLT) and a semantic verbal fluency (SVF) task in a semiautomated phone assessment in a me
Externí odkaz: https://doaj.org/article/57b076a8e51c43649c2884ed3a575440
Zobrazit plný text záznamu
3
Akademický článek
Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework
Autor: Johannes Tröger, Ebru Baykara, Jian Zhao, Daphne ter Huurne, Nina Possemis, Elisa Mallick, Simona Schäfer, Louisa Schwed, Mario Mina, Nicklas Linz, Inez Ramakers, Craig Ritchie
Publikováno v: Digital Biomarkers, Vol 6, Iss 3, Pp 107-116 (2022)
Introduction: Progressive cognitive decline is the cardinal behavioral symptom in most dementia-causing diseases such as Alzheimer’s disease. While most well-established measures for cognition might not fit tomorrow’s decentralized remote clinica
Externí odkaz: https://doaj.org/article/d715274c09c14aa5807f9200f2c82a8f
Zobrazit plný text záznamu
4
Akademický článek
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms
Autor: Ellis Nelissen, Nina Possemis, Nick P. Van Goethem, Melissa Schepers, Danielle A. J. Mulder-Jongen, Lisa Dietz, Wiebke Janssen, Michael Gerisch, Jörg Hüser, Peter Sandner, Tim Vanmierlo, Jos Prickaerts
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting on
Externí odkaz: https://doaj.org/article/d63fa56a4c67428fba25c3c4f7e5efab
Zobrazit plný text záznamu
5
Akademický článek
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Autor: Gemma Gomez-Giro, Jonathan Arias-Fuenzalida, Javier Jarazo, Dagmar Zeuschner, Muhammad Ali, Nina Possemis, Silvia Bolognin, Rashi Halder, Christian Jäger, Willemijn F. E. Kuper, Peter M. van Hasselt, Holm Zaehres, Antonio del Sol, Herman van der Putten, Hans R. Schöler, Jens C. Schwamborn
Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric neurodegeneration. The genetic disorder, which is caused by recessive mutations affec
Externí odkaz: https://doaj.org/article/e28ca03024ec42bf892e968c69946796
Zobrazit plný text záznamu
6
Screening for Mild Cognitive Impairment Using a Machine Learning Classifier and the Remote Speech Biomarker for Cognition
Autor: Simona, Schäfer, Elisa, Mallick, Louisa, Schwed, Alexandra, König, Jian, Zhao, Nicklas, Linz, Timothy Hadarsson, Bodin, Johan, Skoog, Nina, Possemis, Daphne, Ter Huurne, Anna, Zettergren, Silke, Kern, Simona, Sacuiu, Inez, Ramakers, Ingmar, Skoog, Johannes, Tröger
Publikováno v: Journal of Alzheimer's Disease, 91(3), 1165-1171. IOS Press
BACKGROUND: Modern prodromal Alzheimer's disease (AD) clinical trials might extend outreach to a general population, causing high screen-out rates and thereby increasing study time and costs. Thus, screening tools that cost-effectively detect mild co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309dee186fd0b3643ecb8375d6ea4d0f
https://doi.org/10.3233/jad-220762
Zobrazit plný text záznamu
7
The value of maintaining cognition in patients with mild cognitive impairment
Autor: Ron Handels, Sabine Grimm, Arjan Blokland, Nina Possemis, Inez Ramakers, Anke Sambeth, Frans Verhey, Stephanie Vos, Manuela Joore, Jos Prickaerts, Linus Jönsson
Publikováno v: Alzheimer's & Dementia. Elsevier Science
INTRODUCTION: Early health-technology assessment can support discussing scarce resource allocation among stakeholders. We explored the value of maintaining cognition in patients with mild cognitive impairment (MCI) by estimating: (1) the innovation h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b39cafdcd89be3cabc74620d81b09c
https://doi.org/10.1002/alz.13001
Zobrazit plný text záznamu
8
The Accuracy of Speech and Linguistic Analysis in Early Diagnostics of Neurocognitive Disorders in a Memory Clinic Setting
Autor: Daphne ter Huurne, Inez Ramakers, Nina Possemis, Leonie Banning, Angelique Gruters, Stephanie Van Asbroeck, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Frans Verhey, Marjolein de Vugt
Publikováno v: Archives of Clinical Neuropsychology.
Objective To investigate whether automatic analysis of the Semantic Verbal Fluency test (SVF) is reliable and can extract additional information that is of value for identifying neurocognitive disorders. In addition, the associations between the auto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c9b2306b9d3201b0e91f334358209
https://doi.org/10.1093/arclin/acac105
Zobrazit plný text záznamu
10
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Autor: Rashi Halder, Herman van der Putten, Jens Christian Schwamborn, Antonio del Sol, Hans R. Schöler, Christian Jäger, Silvia Bolognin, Holm Zaehres, Nina Possemis, Javier Jarazo, Jonathan Arias-Fuenzalida, Gemma Gomez-Giro, Muhammad Ali, Peter M. van Hasselt, Willemijn F. E. Kuper, Dagmar Zeuschner
Publikováno v: Acta neuropathologica communications, 7(1):222. BioMed Central Ltd
Acta Neuropathologica Communications
Acta neuropathologica communications, 7(1). BioMed Central
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric neurodegeneration. The genetic disorder, which is caused by recessive mutations affecting the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8070eb459a622390056c7cc62c62e3
https://doi.org/10.1186/s40478-019-0871-7
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje