Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nina, Korsisaari"'
Autor:
Napoleone Ferrara, Franklin V. Peale, Nicholas Van Bruggen, William F. Forrest, Jeffrey Eastham-Anderson, Linda Hall, Navneet Pal, Marcin Kowanetz, Xiumin Wu, Jed Ross, Nina Korsisaari
Purpose: Multiple endocrine neoplasia type 1 (MEN1) is defined clinically by the combined occurrence of multiple tumors, typically of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland. A mouse model with a heterozygous dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ad9f1da6745824085a2fe0a7d60949
https://doi.org/10.1158/1078-0432.c.6518419.v1
https://doi.org/10.1158/1078-0432.c.6518419.v1
Autor:
Napoleone Ferrara, Franklin V. Peale, Nicholas Van Bruggen, William F. Forrest, Jeffrey Eastham-Anderson, Linda Hall, Navneet Pal, Marcin Kowanetz, Xiumin Wu, Jed Ross, Nina Korsisaari
Supplementary Figures S1-S2 from Blocking Vascular Endothelial Growth Factor-A Inhibits the Growth of Pituitary Adenomas and Lowers Serum Prolactin Level in a Mouse Model of Multiple Endocrine Neoplasia Type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd19138f0441fb03d8e0b897cb28a05
https://doi.org/10.1158/1078-0432.22441330
https://doi.org/10.1158/1078-0432.22441330
Autor:
Franklin Peale, Napoleone Ferrara, Ian Kasman, William F. Forrest, Ron Smits, Wei Bai, Navneet Pal, Nina Korsisaari, Germaine Fuh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10625-10630. National Academy of Sciences
Anti-VEGF-A monoclonal antibodies, in combination with chemotherapy, result in a survival benefit in patients with metastatic colorectal and non-small cell lung cancer, but little is known regarding the impact of anti-VEGF-A therapy on benign or prem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e48f161020100a8f9990606132d331
https://doi.org/10.1073/pnas.0704213104
https://doi.org/10.1073/pnas.0704213104
Autor:
Derrick J. Rossi, Kay Huebner, Nina Korsisaari, Tomi P. Mäkelä, Keijo Luukko, Mark Henkemeyer
Publikováno v:
Molecular and Cellular Biology. 23:3929-3935
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study the function of Hint and to explore its possible role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468bed8fc1ceab0466e2ef0e31cde2f4
https://doi.org/10.1128/mcb.23.11.3929-3935.2003
https://doi.org/10.1128/mcb.23.11.3929-3935.2003
Autor:
Lauri A. Aaltonen, Virpi Launonen, Keijo Luukko, Nina Korsisaari, Tomi P. Mäkelä, Ari Ristimäki, Antti Ylikorkala, Mark Henkemeyer, Derrick J. Rossi, Reijo Salovaara
Publikováno v:
Proceedings of the National Academy of Sciences. 99:12327-12332
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc6357a0ec74acee8900d5272133636
https://doi.org/10.1073/pnas.192301399
https://doi.org/10.1073/pnas.192301399
Autor:
Derrick J. Rossi, Kari Alitalo, Antti Ylikorkala, Nina Korsisaari, Keijo Luukko, Tomi P. Mäkelä, Mark Henkemeyer
Publikováno v:
Science. 293:1323-1326
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2204c858c13723c4551e45e3ac99d4d2
https://doi.org/10.1126/science.1062074
https://doi.org/10.1126/science.1062074
Autor:
Derrick J. Rossi, Eero Lehtonen, Anou Londesborough, Mark Henkemeyer, Arno Pihlak, Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
The EMBO Journal. 20:2844-2856
The trimeric Cdk7-cyclin H-Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase. Herein we report that disruption of the murine Mat1 gene lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd758f04310ff5461cd7a56f3cc0af
https://doi.org/10.1093/emboj/20.11.2844
https://doi.org/10.1093/emboj/20.11.2844
Autor:
Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
Journal of Biological Chemistry. 275:34837-34840
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1c6567e12102c0f9a14d943a42ed5
https://doi.org/10.1074/jbc.c000505200
https://doi.org/10.1074/jbc.c000505200
Autor:
Jed Ross, Thijs J. Hagenbeek, Tim C. Cao, Lanlan Yu, Mary J. C. Ludlam, Robby M. Weimer, Franklin Peale, Napoleone Ferrara, Xueping Qu, Marcin Kowanetz, Nina Korsisaari, Nicholas van Bruggen, Zora Modrusan, John G. Lee, Xiumin Wu, Y. Gloria Meng, Joshua S. Kaminker, Hani Bou-Reslan, Dara Y. Kallop, Richard A.D. Carano, Martha Tan
Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined overexpress granulocyte-colony stimulating factor (G-CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca80c7124be694c682054afd1ace1fd
https://europepmc.org/articles/PMC3003076/
https://europepmc.org/articles/PMC3003076/
Autor:
Napoleone Ferrara, William F. Forrest, Franklin Peale, Jed Ross, Xiumin Wu, Linda Hall, Jeffrey Eastham-Anderson, Nina Korsisaari, Nicholas van Bruggen, Marcin Kowanetz, Navneet Pal
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(1)
Purpose: Multiple endocrine neoplasia type 1 (MEN1) is defined clinically by the combined occurrence of multiple tumors, typically of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland. A mouse model with a heterozygous dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3655db2402420e0e24be6381562e655
https://pubmed.ncbi.nlm.nih.gov/18172277
https://pubmed.ncbi.nlm.nih.gov/18172277