Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nina, Heycke"'
Autor:
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C. Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J. Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive to Gq- and Gi-sensitive G protein-coupled receptors (G
Externí odkaz:
https://doaj.org/article/be62b1c248c547b084b1b6712cdf03af
Autor:
Junken Aoki, Evi Kostenis, Daniela Wenzel, Nicole Merten, Nina Heycke, Maddalena Vescovo, Bernd K. Fleischmann, Ina Maria Albrecht, Katharina Simon, Alexander Pfeifer, Michaela Matthey, Gabriele M. König, Stephanie Hennen, Francois Marie Ngako Kadji, Felix Häberlein, Bernhard Nieswandt, Timo Vögtle, Kouki Kawakami, Julian Brands, Suzune Hiratsuka, Jaspal Garg, Asuka Inoue, Eva Marie Pfeil, Akos Heinemann, Marie Lise Jobin, Yuki Ono, Kerstin Seier, Davide Calebiro, Ulrike Rick
Mechanisms that control mobilization of cytosolic calcium [Ca2+]i are key for regulation of numerous eukaryotic cell functions. One such paradigmatic mechanism involves activation of phospholipase Cβ (PLCβ) enzymes by G protein βγ subunits from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67b365bfcd1d76a4cd31c504e9faee2
http://hdl.handle.net/11390/1205646
http://hdl.handle.net/11390/1205646
Autor:
Hao-Fu Dai, Max Crüsemann, Evi Kostenis, Raphael Reher, Gabriele M. König, Christa E. Müller, Nina Heycke, Suvi Annala, Stefan Kehraus, Markus Kuschak
Publikováno v:
Journal of Natural Products. 81:1628-1635
The cyclic depsipeptide FR900359 (FR), isolated from the traditional Chinese medicine plant Ardisia crenata, is a potent Gq protein inhibitor and thus a valuable tool to study Gq-mediated signaling of G protein-coupled receptors. Two new FR analogues
Autor:
Suvi, Annala, Xiaodong, Feng, Naveen, Shridhar, Funda, Eryilmaz, Julian, Patt, JuHee, Yang, Eva M, Pfeil, Rodolfo Daniel, Cervantes-Villagrana, Asuka, Inoue, Felix, Häberlein, Tanja, Slodczyk, Raphael, Reher, Stefan, Kehraus, Stefania, Monteleone, Ramona, Schrage, Nina, Heycke, Ulrike, Rick, Sandra, Engel, Alexander, Pfeifer, Peter, Kolb, Gabriele, König, Moritz, Bünemann, Thomas, Tüting, José, Vázquez-Prado, J Silvio, Gutkind, Evelyn, Gaffal, Evi, Kostenis
Publikováno v:
Science signaling. 12(573)
Somatic gain-of-function mutations of
Autor:
Xiaodong Feng, Stefania Monteleone, Felix Häberlein, Julian Patt, José Vázquez-Prado, Ramona Schrage, Funda Eryilmaz, Gabriele M. König, Moritz Bünemann, Asuka Inoue, Evelyna Gaffal, Sandra Engel, Tanja Slodczyk, Naveen Shridhar, Peter Kolb, J. Silvio Gutkind, Nina Heycke, Ulrike Rick, Evi Kostenis, Ju Hee Yang, Suvi Annala, Eva Marie Pfeil, Stefan Kehraus, Raphael Reher, Rodolfo Daniel Cervantes-Villagrana, Alexander Pfeifer, Thomas Tüting
Publikováno v:
Science Signaling. 12
Somatic gain-of-function mutations of GNAQ and GNA11, which encode α subunits of heterotrimeric Gαq/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the adult eye. Molecular therapies to directly target the
Autor:
Evi Kostenis, Nicole Merten, Max Crüsemann, Julian Patt, Nina Heycke, Uli Rick, Eva Marie Pfeil, Gabriele M. König, Funda Eryilmaz, Stefan Kehraus, Jan H. Voss, Xavier Deupi, Christa E. Müller, Asuka Inoue, Judith Alenfelder
Publikováno v:
The Journal of Biological Chemistry
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in the regulation of diverse biological processes. An emergi
Autor:
Max Crüsemann, Ute Hentschel, Matthias Kracht, Jörn Piel, Christian Rinke, Eric J. N. Helfrich, Micheal C. Wilson, Susanne Schmitt, Tetsushi Mori, Alexander O. Brachmann, Agustinus Robert Uria, Shigeki Matsunaga, Kentaro Takada, Ikuro Abe, Christian Rückert, Ursula A. E. Steffens, Toshiyuki Wakimoto, Nina Heycke, Jörn Kalinowski, Cristian Gurgui, Maximilian J. Helf, Christine Gernert, Haruko Takeyama
Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe29e733a12267695ddf40e7960b7db
https://oceanrep.geomar.de/id/eprint/28924/
https://oceanrep.geomar.de/id/eprint/28924/
Autor:
Susanne Schmitt, Ursula A. E. Steffens, Nina Heycke, Cristian Gurgui, Jörn Kalinowski, Toshiyuki Wakimoto, Ute Hentschel, Max Crüsemann, Ikuro Abe, Alexander O. Brachmann, Christian Rückert, Christine Gernert, Micheal C. Wilson, Jörn Piel, Haruko Takeyama, Agustinus Robert Uria, Kentaro Takada, Eric J. N. Helfrich, Maximilian J. Helf, Christian Rinke, Matthias Kracht, Tetsushi Mori, Shigeki Matsunaga
Nature 506, 58–62 (2014); doi:10.1038/nature12959 One of the accession numbers for this Article was listed as AZHXW01000000 instead of AZHX01000000. It has been corrected in the online versions of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60af18829e5c9f6014f600ee602b9add
https://pub.uni-bielefeld.de/record/2944854
https://pub.uni-bielefeld.de/record/2944854
Publikováno v:
Molecular genetics of plant-microbe interactions ISBN: 9789401084963
The biological rationale for the Agrobacterium-crowngall interaction is the production of opines (1,2). The redirection of plant metabolites into a form which the inducing bacteria, but few others, can utilize ensures a competitive advantage to the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd59b6541ac363a589c2a90867f02c1
https://doi.org/10.1007/978-94-009-4482-4_73
https://doi.org/10.1007/978-94-009-4482-4_73
Forty-nine fast-growing Rhizobium strains from the nodules of 26 different tropical legume genera were screened to find isolates that would ( i ) nodulate, e.g., winged beans, so producing large nodules for RNA and protein isolation; ( ii ) also nodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93d3083a12a3080cf42355fb94dbd3c
https://europepmc.org/articles/PMC345227/
https://europepmc.org/articles/PMC345227/