Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nina, Franko"'
Autor:
Igor Snapkow, Nicola M. Smith, Emma Arnesdotter, Karsten Beekmann, Etienne B. Blanc, Albert Braeuning, Emanuela Corsini, Marija Sollner Dolenc, Loes P. M. Duivenvoorde, Gunnar Sundstøl Eriksen, Nina Franko, Valentina Galbiati, Johanna M. Gostner, Nathalie Grova, Arno C. Gutleb, Rita Hargitai, Aafke W. F. Janssen, Solveig A. Krapf, Birgitte Lindeman, Katalin Lumniczky, Ambra Maddalon, Steen Mollerup, Lucia Parráková, Arkadiusz Pierzchalski, Raymond H. H. Pieters, Maria J. Silva, Anita Solhaug, Yvonne C. M. Staal, Anne Straumfors, Tünde Szatmári, Jonathan D. Turner, Rob J. Vandebriel, Ana Claudia Zenclussen, Robert Barouki
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms,
Externí odkaz:
https://doaj.org/article/27a61a2796534e779b630318da5896bf
Autor:
Nina Franko, Marija Sollner Dolenc
Publikováno v:
Toxics, Vol 12, Iss 8, p 607 (2024)
The strong appeal to reduce animal testing calls for the development and validation of in vitro, in chemico and in silico models that would replace the need for in vivo testing and ex vivo materials. A category that requires such new approach methods
Externí odkaz:
https://doaj.org/article/af696e1ea7bd4926a735abc41ce509f5
Autor:
Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 31-43 (2019)
The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibito
Externí odkaz:
https://doaj.org/article/a7f454e5900149429f6d3c19ae6529c0
Autor:
Giannamaria Annunziato, Costanza Spadini, Marialaura Marchetti, Nina Franko, Marialaura Pavone, Mattia Iannarelli, Agostino Bruno, Marco Pieroni, Stefano Bettati, Clotilde Silvia Cabassi, Barbara Campanini, Gabriele Costantino
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 766 (2022)
Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that O-acetylserine sulfhydrylase (OASS) in
Externí odkaz:
https://doaj.org/article/a4c0d428c9844ac3b8d2f6512eb7e7a4
Autor:
Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1444-1452 (2018)
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine
Externí odkaz:
https://doaj.org/article/30e250b250a64c3580f2300940788456
Autor:
Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1343-1351 (2018)
O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its inactivation is pursued as a strategy for the identification of novel antibiotics that, target
Externí odkaz:
https://doaj.org/article/a7e0e91b87094e65a788a7ae2816f491
Autor:
Joana Magalhães, Nina Franko, Samanta Raboni, Giannamaria Annunziato, Päivi Tammela, Agostino Bruno, Stefano Bettati, Stefano Armao, Costanza Spadini, Clotilde Silvia Cabassi, Andrea Mozzarelli, Marco Pieroni, Barbara Campanini, Gabriele Costantino
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 174 (2021)
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents o
Externí odkaz:
https://doaj.org/article/f1d7405d6d5a4d12aad19e9550530af9
Autor:
Costanza Spadini, Nicola Demitri, Marialaura Marchetti, Paola Storici, Barbara Campanini, Giannamaria Annunziato, Clotilde Silvia Cabassi, Mattia Iannarelli, Joana Magalhães, Andrea Mozzarelli, Sara Flisi, Nina Franko, Gabriele Costantino, Lucrezia Rosati, Stefano Bettati, Marco Pieroni
Publikováno v:
ACS Infectious Diseases 7 (2021): 281–292. doi:10.1021/acsinfecdis.0c00378
info:cnr-pdr/source/autori:Annunziato G.; Spadini C.; Franko N.; Storici P.; Demitri N.; Pieroni M.; Flisi S.; Rosati L.; Iannarelli M.; Marchetti M.; Magalhaes J.; Bettati S.; Mozzarelli A.; Cabassi C.S.; Campanini B.; Costantino G./titolo:Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant/doi:10.1021%2Facsinfecdis.0c00378/rivista:ACS Infectious Diseases/anno:2021/pagina_da:281/pagina_a:292/intervallo_pagine:281–292/volume:7
info:cnr-pdr/source/autori:Annunziato G.; Spadini C.; Franko N.; Storici P.; Demitri N.; Pieroni M.; Flisi S.; Rosati L.; Iannarelli M.; Marchetti M.; Magalhaes J.; Bettati S.; Mozzarelli A.; Cabassi C.S.; Campanini B.; Costantino G./titolo:Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant/doi:10.1021%2Facsinfecdis.0c00378/rivista:ACS Infectious Diseases/anno:2021/pagina_da:281/pagina_a:292/intervallo_pagine:281–292/volume:7
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventional antibiotics to be lowered and reduce the insurgence of antibiotic resistance. Herein, we report that an O-acetylserine sulfhydrylase (OASS) inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c68e36016f4f3621d1d6d707d9574a
https://doi.org/10.1021/acsinfecdis.0c00378
https://doi.org/10.1021/acsinfecdis.0c00378
Autor:
Giannamaria, Annunziato, Costanza, Spadini, Marialaura, Marchetti, Nina, Franko, Marialaura, Pavone, Mattia, Iannarelli, Agostino, Bruno, Marco, Pieroni, Stefano, Bettati, Clotilde Silvia, Cabassi, Barbara, Campanini, Gabriele, Costantino
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(6)
Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5229049cb22ebb3de6c1fa87236e5fde
https://pubmed.ncbi.nlm.nih.gov/35745685
https://pubmed.ncbi.nlm.nih.gov/35745685
Publikováno v:
International journal of molecular sciences, str. 1-17 : ilustr., Vol. 23, no. 8, 2022
COBISS-ID: 2779162
International journal of molecular sciences, vol. 23, no. 8, 4257, 2022.
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4257
COBISS-ID: 2779162
International journal of molecular sciences, vol. 23, no. 8, 4257, 2022.
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4257
RT-qPCR is the gold standard and the most commonly used method for measuring gene expression. Selection of appropriate reference gene(s) for normalization is a crucial part of RT-qPCR experimental design, which allows accurate quantification and reli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce06a395c43c2ea74cf041c94016c1f9
https://d.cobiss.net/repository/si/files/105244163/99876/ijms-23-04257.pdf/terms
https://d.cobiss.net/repository/si/files/105244163/99876/ijms-23-04257.pdf/terms
