Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nina, Dirkx"'
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing. Pathogenic loss-of-
Externí odkaz:
https://doaj.org/article/adc39b6beb6641489b474294fef71909
Autor:
Daniëlle Copmans, Sara Kildgaard, Silas A. Rasmussen, Monika Ślęzak, Nina Dirkx, Michèle Partoens, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 607 (2019)
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf
Externí odkaz:
https://doaj.org/article/f55527d449b24d7bb5f42251a1982621
Autor:
Mercedes Pérez-Bonilla, Alan James Smith, José Pérez del Palacio, Fernando Reyes, Caridad Díaz, Peter de Witte, Nina Dirkx, Daniëlle Copmans, Jioji N. Tabudravu, Riccardo Vallorani, Marcel Jaspars, Mostafa E. Rateb, Rainer Ebel
Publikováno v:
ACS Chemical Neuroscience. 9:1652-1662
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c45c4b47764a05cef8fcb71ec911da
https://doi.org/10.1021/acschemneuro.8b00060
https://doi.org/10.1021/acschemneuro.8b00060
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Metabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1eb28522a6981e2d71c7605bd41caf4
https://pubmed.ncbi.nlm.nih.gov/31501497
https://pubmed.ncbi.nlm.nih.gov/31501497
Autor:
Silas Anselm Rasmussen, Sara Kildgaard, Monika Ślęzak, Camila V. Esguerra, Thomas Ostenfeld Larsen, Daniëlle Copmans, Peter de Witte, Michèle Partoens, Nina Dirkx, Alexander D. Crawford
Publikováno v:
Copmans, D, Kildgaard, S, Rasmussen, S A, Ślezak, M, Dirkx, N, Partoens, M, Esguerra, C V, Crawford, A D, Larsen, T O & De Witte, P A M 2019, ' Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B ', Marine Drugs, vol. 17, no. 11, 607 . https://doi.org/10.3390/md17110607
Marine Drugs
Volume 17
Issue 11
Marine Drugs, Vol 17, Iss 11, p 607 (2019)
Marine Drugs
Volume 17
Issue 11
Marine Drugs, Vol 17, Iss 11, p 607 (2019)
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163678ca13c9692a5812464006f13c1d
https://orbit.dtu.dk/en/publications/1cba1001-99b4-4b69-92ff-cfda39e4aa59
https://orbit.dtu.dk/en/publications/1cba1001-99b4-4b69-92ff-cfda39e4aa59
Autor:
Subhrajit Bhattacharya, Varun Kannan, Hirofumi Kusumoto, Yuehua Zhang, Gabrielle J. Kosobucki, An-Sofie Schoonjans, Annapurna Poduri, Sylvie Nguyen, Xinhua Bao, Elias Aizenman, Elisabeth Schuler, Dragan Marjanovic, Hongjie Yuan, Scott J. Myers, Christelle Moufawad El Achkar, Christina Fenger, Nina Dirkx, Gaetan Lesca, Yuwu Jiang, Stephen F. Traynelis, Jean-Marie Cuisset, Ye Wu, Wenshu XiangWei, Steffen Syrbe, Katherine L. Helbig, Anthony J. Schulien, Johannes R. Lemke, Yuchen Xu
Publikováno v:
Brain
N-methyl D-aspartate receptors are ligand-gated ionotropic receptors mediating a slow, calcium-permeable component of excitatory synaptic transmission in the CNS. Variants in genes encoding NMDAR subunits have been associated with a spectrum of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4160e0d5c019871f4b8fb7caebbcbf36
https://hdl.handle.net/10067/1657750151162165141
https://hdl.handle.net/10067/1657750151162165141
Autor:
Daniëlle, Copmans, Mostafa, Rateb, Jioji N, Tabudravu, Mercedes, Pérez-Bonilla, Nina, Dirkx, Riccardo, Vallorani, Caridad, Diaz, José, Pérez Del Palacio, Alan J, Smith, Rainer, Ebel, Fernando, Reyes, Marcel, Jaspars, Peter A M, de Witte
Publikováno v:
ACS chemical neuroscience. 9(7)
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25e2cd3816a4655e962d021bb7ae472b
https://pubmed.ncbi.nlm.nih.gov/29672015
https://pubmed.ncbi.nlm.nih.gov/29672015