Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nimrod Philippe"'
Autor:
Arun Cumpelik, Tong Liu, Chengguo Wei, Jui Choudhuri, Ruijie Liu, Kirk N. Campbell, Madhav C. Menon, Nimrod Philippe, Felipe Garzon, Philip J. O'Connell, John Cijiang He, Barbara Murphy, Karen Keung, Weijia Zhang, Jenny Wong, Bhaskar C. Das, Zhengzi Yi, Lewis Kaufman, Paolo Cravedi, Fadi Salem, Miguel Fribourg, Khadija Banu, John M. Basgen, Mubeen Khan
Publikováno v:
Journal of the American Society of Nephrology. 29:2641-2657
Background We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding);
Autor:
Madhav C Menon, Nimrod Philippe, Chengguo Wei, Ruijie Liu, Weijia Zhang, Zhengzi Li, John C He, Barbara Murphy
Publikováno v:
Hypertension. 70
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular Shroom3 expression correlated with the development of fibrosis in renal allografts. We showed that SHROOM3 facilitated TGF-B signaling suggesting its poten
Autor:
Chengguo Wei, Madhav C. Menon, Li Li, Benjamin Readhead, Bernd Schröppel, Rong Chen, Brian A. Kidd, Ilana Greene, Nimrod Philippe, Barbara Murphy, Andrew V. Uzilov, John Cijiang He, Joel T. Dudley
Publikováno v:
Scientific Reports
Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF/TA. We applied a meta-analysis approach