Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nimrod D Rubinstein"'
Autor:
Anita E Autry, Zheng Wu, Vikrant Kapoor, Johannes Kohl, Dhananjay Bambah-Mukku, Nimrod D Rubinstein, Brenda Marin-Rodriguez, Ilaria Carta, Victoria Sedwick, Ming Tang, Catherine Dulac
Publikováno v:
eLife, Vol 10 (2021)
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (
Externí odkaz:
https://doaj.org/article/033c306675694fa58312763ea717d719
Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.
Autor:
Hugo G Hilton, Nimrod D Rubinstein, Peter Janki, Andrea T Ireland, Nicholas Bernstein, Nicole L Fong, Kevin M Wright, Megan Smith, David Finkle, Baby Martin-McNulty, Margaret Roy, Denise M Imai, Vladimir Jojic, Rochelle Buffenstein
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000528 (2019)
The immune system comprises a complex network of specialized cells that protects against infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role in homeostasis, health span, and life span. The subterranean-dwe
Externí odkaz:
https://doaj.org/article/7ccaa2b5062f41649723a8e1c83b849e
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
Barak Rosenzweig, Nimrod D Rubinstein, Ed Reznik, Roman Shingarev, Krishna Juluru, Oguz Akin, James J Hsieh, Edgar A Jaimes, Paul Russo, Katalin Susztak, Jonathan A Coleman, A Ari Hakimi
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180350 (2017)
BACKGROUND AND OBJECTIVES:Pre-operative kidney volume is an independent predictor of glomerular filtration rate in renal cell carcinoma patients. Compensatory renal growth (CRG) can ensue prior to nephrectomy in parallel to tumor growth and benign pa
Externí odkaz:
https://doaj.org/article/4c4d796e7e0e46ddaa48bf45438d38f9
Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
Autor:
Julio D Perez, Nimrod D Rubinstein, Daniel E Fernandez, Stephen W Santoro, Leigh A Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun Chen, Jun S Liu, Catherine Dulac
Publikováno v:
eLife, Vol 4 (2015)
The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic imprinting in
Externí odkaz:
https://doaj.org/article/a9b57bdbce1841869bebf9aa693b4b3c
Autor:
Tzuhua D. Lin, Nimrod D. Rubinstein, Nicole L. Fong, Megan Smith, Wendy Craft, Baby Martin-McNulty, Rebecca Perry, Martha A. Delaney, Margaret A. Roy, Rochelle Buffenstein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destro
Externí odkaz:
https://doaj.org/article/d02f7f07176341dc8d7d3f69378343c5
Autor:
Osnat Penn, Adi Stern, Nimrod D Rubinstein, Julien Dutheil, Eran Bacharach, Nicolas Galtier, Tal Pupko
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 11, p e1000214 (2008)
A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests tha
Externí odkaz:
https://doaj.org/article/ed1d317d6cfb4ef0bee1ce8aa5d73943
Autor:
Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang, Emily Jacobs-Palmer, Nydia Chang, Christian Much, Kyle M. Turner, Christopher Kirby, Nimrod D. Rubinstein, Abigail F. Groff, Steve C. Liapis, Chiara Gerhardinger, Assaf Bester, Pier Paolo Pandolfi, John G. Clohessy, Hopi E. Hoekstra, Martin Sauvageau, John L. Rinn
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, studyin
Externí odkaz:
https://doaj.org/article/c0afc736c1d14340901a97d94751f3ae
Autor:
Nimrod D. Rubinstein, John A. Beaufort, Adam C. Nelson, Oliver J. Rando, Joseph W. Cauceglia, Shweta Kukreja, Wayne K. Potts, Lynsey N. Sasso
Publikováno v:
Molecular Ecology. 29:624-638
One type of parental effect occurs when changes in parental phenotype or environment trigger changes to offspring phenotype. Such nongenetic parental effects can be precisely triggered in response to an environmental cue in time-locked fashion, or in
Autor:
Ming Tang, Johannes Kohl, Dhananjay Bambah-Mukku, Ilaria Carta, Nimrod D. Rubinstein, Anita E. Autry, Victoria Sedwick, Vikrant Kapoor, Catherine Dulac, Zheng Wu, Brenda Marin-Rodriguez
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (