Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nimit L. Patel"'
Autor:
Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Veera V. Shivaji R. Edupuganti, Kuo-Sheng Hsu, Christopher Dower, Guojun Yu, Daeho So, Pradip Bajgain, Zhongyu Zhu, Dimiter S. Dimitrov, Nimit L. Patel, Christina M. Robinson, Simone Difilippantonio, Marzena Dyba, Amanda Corbel, Falguni Basuli, Rolf E. Swenson, Joseph D. Kalen, Sreedhar Reddy Suthe, Myer Hussain, James S. Italia, Colby A. Souders, Ling Gao, Martin J. Schnermann, Brad St. Croix
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113503- (2023)
Summary: CD276/B7-H3 represents a promising target for cancer therapy based on widespread overexpression in both cancer cells and tumor-associated stroma. In previous preclinical studies, CD276 antibody-drug conjugates (ADCs) exploiting a talirine-ty
Externí odkaz:
https://doaj.org/article/01cdeaeafb064caf9db89ad85217f450
Autor:
Sounak Sahu, Mary E. Albaugh, Betty K. Martin, Nimit L. Patel, Lisa Riffle, Susan Mackem, Joseph D. Kalen, Shyam K. Sharan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Signaling pathways play an important role in cell fate determination in stem cells and regulate a plethora of developmental programs, the dysregulation of which can lead to human diseases. Growth factors (GFs) regulating these signaling path
Externí odkaz:
https://doaj.org/article/e78755a689b14a6bb26033fa5a7a037d
Autor:
Kerrie L. Marie, Antonella Sassano, Howard H. Yang, Aleksandra M. Michalowski, Helen T. Michael, Theresa Guo, Yien Che Tsai, Allan M. Weissman, Maxwell P. Lee, Lisa M. Jenkins, M. Raza Zaidi, Eva Pérez-Guijarro, Chi-Ping Day, Kris Ylaya, Stephen M. Hewitt, Nimit L. Patel, Heinz Arnheiter, Sean Davis, Paul S. Meltzer, Glenn Merlino, Pravin J. Mishra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.
Externí odkaz:
https://doaj.org/article/35727847607f4f45b98d5dc601c357f5
Autor:
Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tum
Externí odkaz:
https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd
Autor:
Dong‐Hao Li, Rananjaya S. Gamage, Allen G. Oliver, Nimit L. Patel, Syed Muhammad Usama, Joseph D. Kalen, Martin J. Schnermann, Bradley D. Smith
Publikováno v:
Angewandte Chemie.
Autor:
Ek Raj Thapaliya, Syed Muhammad Usama, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St. Croix, Martin J. Schnermann
Publikováno v:
Bioconjugate Chemistry. 33:718-725
Conjugates of small molecules and antibodies are broadly employed diagnostic and therapeutic agents. Appending a small molecule to an antibody often significantly impacts the properties of the resulting conjugate. Here, we detail a systematic study i
Autor:
Joseph D. Kalen, Syed Muhammad Usama, Brad St. Croix, Yang Feng, Donald R. Caldwell, Nimit L. Patel, Martin J. Schnermann, Sierra Marker
Publikováno v:
Journal of the American Chemical Society. 143:21667-21675
Antibody-drug conjugates (ADCs) are a rapidly emerging therapeutic platform. The chemical linker between the antibody and the drug payload plays an essential role in the efficacy and tolerability of these agents. New methods that quantitively assess
Autor:
Poulami Majumder, Caroline Andrews, Joel P. Schneider, Anand Singh, Scott T. R. Walsh, Kingshuk Dutta, Ziqiu Wang, Chuong D. Hoang, Chen Liang, Albert Byungyun Jeon, Baktiar Karim, Junfeng Shi, Natalia de Val, Roma Pahwa, Nimit L. Patel
Publikováno v:
Nature Nanotechnology. 16:1251-1259
Tumours growing in a sheet-like manner on the surface of organs and tissues with complex topologies represent a difficult-to-treat clinical scenario. Their complete surgical resection is difficult due to the complicated anatomy of the diseased tissue
Autor:
Syed Muhammad Usama, Donald R. Caldwell, Pradeep Shrestha, Michael P. Luciano, Nimit L. Patel, Joseph D. Kalen, Joseph Ivanic, Martin J. Schnermann
Publikováno v:
Biosensorsbioelectronics. 217
Activatable fluorophores with emission beyond 1000 nm have the potential to enable high contrast imaging in complex in vivo settings. However, there are few scaffolds that can be applied to this challenge. Here we detail the synthesis and evaluation
Autor:
Sean Davis, Pravin J. Mishra, Paul S. Meltzer, Stephen M. Hewitt, Yien Che Tsai, Kris Ylaya, Maxwell P. Lee, Helen T. Michael, Lisa M. Miller Jenkins, Allan M. Weissman, Aleksandra M. Michalowski, Glenn Merlino, Chi-Ping Day, Eva Pérez-Guijarro, M. Raza Zaidi, Nimit L. Patel, Howard H. Yang, Antonella Sassano, Kerrie L. Marie, Theresa Guo, Heinz Arnheiter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Marie, K, Sassano, A, Yang, H H, Michalowski, A M, Michael, H T, Guo, T, Tsai, Y C, Weissman, A M, Lee, M P, Jenkins, L M, Zaidi, M R, Pérez-Guijarro, E, Day, C-P, Ylaya, K, Hewitt, S M, Patel, N L, Arnheiter, H, Davis, S, Meltzer, P S, Merlino, G & Mishra, P J 2020, ' Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis ', Nature Communications, vol. 11, 333, pp. 1-18 . https://doi.org/10.1038/s41467-019-14085-2
Nature Communications
Marie, K, Sassano, A, Yang, H H, Michalowski, A M, Michael, H T, Guo, T, Tsai, Y C, Weissman, A M, Lee, M P, Jenkins, L M, Zaidi, M R, Pérez-Guijarro, E, Day, C-P, Ylaya, K, Hewitt, S M, Patel, N L, Arnheiter, H, Davis, S, Meltzer, P S, Merlino, G & Mishra, P J 2020, ' Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis ', Nature Communications, vol. 11, 333, pp. 1-18 . https://doi.org/10.1038/s41467-019-14085-2
Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong propensity to metastasize. We posit that melanoma cells acquire metastatic capability by adopting an embryonic-like phenotype, and that a lineage approach would uncover