Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nimish Gera"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTBiparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics f
Externí odkaz:
https://doaj.org/article/cded80158e66447d85469dfb9b9c7945
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48928 (2012)
We have engineered pH sensitive binding proteins for the Fc portion of human immunoglobulin G (hIgG) (hFc) using two different strategies - histidine scanning and random mutagenesis. We obtained an hFc-binding protein, Sso7d-hFc, through mutagenesis
Externí odkaz:
https://doaj.org/article/a40ba8300b354f0b861397f968075638
Autor:
Nimish Gera
Publikováno v:
Expert Opinion on Biological Therapy. 22:945-949
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6b60a6e859e99109fdb39939b77716
https://doi.org/10.1080/14712598.2022.2040987
https://doi.org/10.1080/14712598.2022.2040987
Autor:
Nimish Gera, Kyle Fitzgerald, Vijay Ramesh, Purvi Patel, Lena Kien, Deepak Kanojia, Simon Aoyama, Federico Colombo, Amit Deshpande, William Comb, Thomas Chittenden, Brian Fiske
Publikováno v:
Cancer Research. 83:5000-5000
MET alterations can act as an oncogenic driver in non-small cell lung cancer (NSCLC) and elevated cMET expression occurs in many cancers. Antibody drug conjugates targeting cMET (cMET-ADCs) have been developed as a strategy to treat cMET+ tumors irre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751199aaeebee84e2b209d0539aa6715
https://doi.org/10.1158/1538-7445.am2023-5000
https://doi.org/10.1158/1538-7445.am2023-5000
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2491
pH-dependent antigen binding has proven useful in engineering next-generation therapeutics specifically via antibody recycling technology. This technology allows for half-life extension, thereby lowering the amount and frequency of dosing of therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab4cad291c7902e35a3402ad41c1502f
https://pubmed.ncbi.nlm.nih.gov/35482197
https://pubmed.ncbi.nlm.nih.gov/35482197
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00332fcb174863e86ad9850fb7b06912
https://doi.org/10.1007/978-1-0716-2285-8_16
https://doi.org/10.1007/978-1-0716-2285-8_16
Publikováno v:
ACS Applied Materials & Interfaces. 5:5298-5306
We present a simple method for attaching silver nanoparticles to polypropylene (PP) fibers in a two-step process to impart antibacterial properties. Specifically, PP fibers are pretreated by the adsorption from an aqueous solution of heat-denatured l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8deaeda4714a6f029cc81c1166f9eb20
https://doi.org/10.1021/am4011644
https://doi.org/10.1021/am4011644
Publikováno v:
Methods. 60:15-26
Binding proteins are typically isolated from combinatorial libraries of scaffold proteins using one of the many library screening tools available, such as phage display, yeast surface display or mRNA display. A key principle underlying these screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002f862055346fa128fe724414fe0992
https://doi.org/10.1016/j.ymeth.2012.03.014
https://doi.org/10.1016/j.ymeth.2012.03.014
Publikováno v:
Journal of Molecular Biology. 409:601-616
We have shown that highly stable binding proteins for a wide spectrum of targets can be generated through mutagenesis of the Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus. Sso7d is a small (~7 kDa, 63 amino acids) DNA-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406d51aa9c84fd9a20a42f84da96c45f
https://doi.org/10.1016/j.jmb.2011.04.020
https://doi.org/10.1016/j.jmb.2011.04.020
Autor:
Ozana Onaca, Nimish Gera, Ulrich Schwaneberg, Madhavan Nallani, Werner Hoheisel, Karlheinz Hildenbrand
Publikováno v:
Biotechnology Journal. 1:828-834
A nanocompartment system composed of an ABA triblock copolymer, where A is poly(dimethylsiloxane) and B is poly(2-methyloxazoline), has been developed for selective recovery and detection of DNA. Translocation of TAMRA-labeled complementary primers i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f30a6b538f6e04698ed5b7e6c7dacb
https://doi.org/10.1002/biot.200600042
https://doi.org/10.1002/biot.200600042