Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations.

Autor: Liu D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dol31@pitt.edu., Meyer D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fennessy B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Feng C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Wellcome Sanger Institute, Hinxton, UK., Cheng E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Johnson JS; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Park YJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rieder MK; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ascolillo S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Pins A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dobbyn A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lebovitch D; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Moya E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nguyen TH; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Wilkins L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hassan A; University of Peshawar, Peshawar, Pakistan., Burdick KE; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Domenici E; Centre for Computational and Systems Biology, Fondazione The Microsoft Research - University of Trento, Rovereto, Italy.; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Frangou S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Hartmann AM; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Laurent-Levinson C; Faculté de Médecine Sorbonne Université, Groupe de Recherche Clinique n°15-Troubles Psychiatriques et Développement, Department of Child and Adolescent Psychiatry, Hôpital Universitaire de la Pitié-Salpêtrière, Paris, France.; Centre de Référence des Maladies Rares à Expression Psychiatrique, Department of Child and Adolescent Psychiatry, AP-HP Sorbonne Université, Hôpital Universitaire de la Pitié-Salpêtrière, Paris, France., Malhotra D; Department of Neuroscience and Rare Diseases, Roche Pharma Research and Early Development, F. Hoffmann-La Roche, Basel, Switzerland., Pato CN; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, New York, NY, USA., Pato MT; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, New York, NY, USA., Ressler K; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA., Roussos P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, New York, NY, USA., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Arango C; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain., Bertolino A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Blasi G; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Bocchio-Chiavetto L; Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Italy.; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Campion D; INSERM U1245, Rouen, France.; Centre Hospitalier du Rouvray, Rouen, France., Carr V; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Department of Psychiatry, School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia., Fullerton JM; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Gennarelli M; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., González-Peñas J; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain., Levinson DF; Department of Psychiatry, Stanford University, Stanford, CA, USA., Mowry B; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Queensland, Australia., Nimgaokar VL; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Pergola G; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Rampino A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Cervilla JA; Institute of Neurosciences, Biomedical Research Centre, University of Granada, Granada, Spain.; Department of Psychiatry, San Cecilio University Hospital, University of Granada, Granada, Spain., Rivera M; Institute of Neurosciences, Biomedical Research Centre, University of Granada, Granada, Spain.; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain., Schwab SG; Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia., Wildenauer DB; The University of Western Australia, Perth, Western Australia, Australia., Daly M; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Neale B; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Singh T; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Walters JT; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Ayub M; University College London, London, UK.; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Malhotra AK; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, New York, NY, USA., Lencz T; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, New York, NY, USA., Sullivan PF; Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sklar P; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stahl EA; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Huckins LM; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. laura.huckins@mssm.edu., Charney AW; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Mar; Vol. 55 (3), pp. 369-376. Date of Electronic Publication: 2023 Mar 13.