Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nima N Naseri"'
Autor:
Nima N Naseri, Joseph Bonica, Hui Xu, Larry C Park, Jamshid Arjomand, Zhengming Chen, Gary E Gibson
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0160384 (2016)
Metabolic dysfunction is well-documented in Huntington's disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main metabolic pathway for the production of NA
Externí odkaz:
https://doaj.org/article/55ce99018e394d29bc1b712d904d5c15
Publikováno v:
Clin Genet
The neuronal ceroid lipofuscinoses (NCLs) are at least 13 distinct progressive neurodegenerative disorders unified by the accumulation of lysosomal auto-fluorescent material called lipofuscin. The only form that occurs via autosomal-dominant inherita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d844e356380aaf783d314b009046db8a
https://doi.org/10.1111/cge.13829
https://doi.org/10.1111/cge.13829
Autor:
Parinati Kharel, Jacqueline Burré, Milen Velinov, Nima N. Naseri, Manu Sharma, Natalia Dolzhanskaya, Rong Huang, Burce Ergel, Qingqiu Huang, Yoonmi Na
Publikováno v:
Nature structural & molecular biology
Point mutations in cysteine string protein-α (CSPα) cause dominantly inherited adult-onset neuronal ceroid lipofuscinosis (ANCL), a rapidly progressing and lethal neurodegenerative disease with no treatment. ANCL mutations are proposed to trigger C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856ae3c6b665673b561e08966ca0f93b
https://doi.org/10.1038/s41594-020-0375-y
https://doi.org/10.1038/s41594-020-0375-y
Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain, amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) peptides and hyperphosphorylated tau, respectively. Although accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8231009bf1fc48423a00b5e3766d657
https://europepmc.org/articles/PMC7060758/
https://europepmc.org/articles/PMC7060758/
Autor:
Etty Cortes, Gary E. Gibson, Jamshid Arjomand, Joseph Bonica, Nima N. Naseri, Jean Paul G. Vonsattel, Hui Xu, Larry Park
Glucose metabolism is reduced in the brains of patients with Huntington disease (HD). The mechanisms underlying this deficit, its link to the pathology of the disease, and the vulnerability of the striatum in HD remain unknown. Abnormalities in some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a7449d9d7b7c76c46bf53050656da0
https://europepmc.org/articles/PMC4435838/
https://europepmc.org/articles/PMC4435838/
Autor:
Arie Neymotin, Karen T. Liby, Elizabeth Wille, Renee Risingsong, Noel Y. Calingasan, M. Flint Beal, Michael B. Sporn, Nima N. Naseri, Maria Damiano, Mahmoud Kiaei, Susanne Petri
Oxidative damage, neuroinflammation, and mitochondrial dysfunction contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), and these pathologic processes are tightly regulated by the Nrf2/ARE (NF-E2-related factor 2/antioxidant respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ed3ee74ba394bb3082804e2046d02c
https://europepmc.org/articles/PMC3109235/
https://europepmc.org/articles/PMC3109235/
Autor:
Ying Xue Xie, Nima N. Naseri, Jasmine Fels, Parinati Kharel, Yoonmi Na, Diane Lane, Jacqueline Burré, Manu Sharma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Release of α-synuclein aggregates by neurons instigates spread of pathology in synucleinopathies, but the mechanism remains unclear. Here the authors show that neuronally generated α-synuclein aggregates accumulate within neuronal lysosomes and are
Externí odkaz:
https://doaj.org/article/bb879c277162488aa71514ea44aa89e5
Autor:
Mirzaei F; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Abbasi E; Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. 7abbasi@gmail.com., Mirzaei A; Centre Énergie, Matériaux Et Télécommunications, Institut National de La Recherche Scientifique, 1650 Boulevard Lionel-Boulet, Varennes, Québec, J3X 1P7, Canada., Hosseini NF; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Naseri N; Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Khodadadi I; Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Jalili C; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran., Majdoub N; Faculdade de Ciências E Tecnologia, Universidade Do Algarve, Campus de Gambelas, 8005-139, Faro, MeditBio, Portugal.
Publikováno v:
Biological trace element research [Biol Trace Elem Res] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.
Autor:
Raoufinia R; Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran., Arabnezhad A; Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran., Keyhanvar N; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, 94107, USA., Abdyazdani N; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Saburi E; Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Naseri N; Department of Biochemistry, School of medicine, Hamadan University of medical sciences, Hamadan, Iran., Niazi F; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Niazi F; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Namdar AB; Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Rahimi HR; Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. rahimihr@mums.ac.ir.
Publikováno v:
Molecular biology reports [Mol Biol Rep] 2024 Mar 29; Vol. 51 (1), pp. 459. Date of Electronic Publication: 2024 Mar 29.