Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Nima, C."'
Autor:
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and ident
Externí odkaz:
https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee8
Autor:
Sara R. Rashkin, Rebecca E. Graff, Linda Kachuri, Khanh K. Thai, Stacey E. Alexeeff, Maruta A. Blatchins, Taylor B. Cavazos, Douglas A. Corley, Nima C. Emami, Joshua D. Hoffman, Eric Jorgenson, Lawrence H. Kushi, Travis J. Meyers, Stephen K. Van Den Eeden, Elad Ziv, Laurel A. Habel, Thomas J. Hoffmann, Lori C. Sakoda, John S. Witte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals o
Externí odkaz:
https://doaj.org/article/45eda6708b934235846a8a794af520d2
Autor:
Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen Lopez, Imelda Tenggara, Jeffry P. Simko, Terence W. Friedlander, Patricia S. Li, Pamela L. Paris, Peter R. Carroll, John S. Witte
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel desig
Externí odkaz:
https://doaj.org/article/4b8f1ffaa66a497293d31c9ad249bfe8
Autor:
Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bossé, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardón, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeböller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loïc Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma’en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and l
Externí odkaz:
https://doaj.org/article/bff7e82d5b6d44f0880ccdf00acf35df
Autor:
Nima C. Emami, Linda Kachuri, Travis J. Meyers, Rajdeep Das, Joshua D. Hoffman, Thomas J. Hoffmann, Donglei Hu, Jun Shan, Felix Y. Feng, Elad Ziv, Stephen K. Van Den Eeden, John S. Witte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In prostate cancer, investigating aberrant gene expression may shed light on disease etiology. Here, the authors imputed expression transcriptome-wide for 233,955 European ancestry men, discovering and replicating the associations between prostatic e
Externí odkaz:
https://doaj.org/article/ea68863cb6aa42d9926f549fb3fe9771
Autor:
Manuel A R Ferreira, Judith M Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu, Sarah Grosche, Franz Rüschendorf, Raquel Granell, Ben M Brumpton, Lars G Fritsche, Laxmi Bhatta, Maiken E Gabrielsen, Jonas B Nielsen, Wei Zhou, Kristian Hveem, Arnulf Langhammer, Oddgeir L Holmen, Mari Løset, Gonçalo R Abecasis, Cristen J Willer, Nima C Emami, Taylor B Cavazos, John S Witte, Agnieszka Szwajda, andMe Research Team, collaborators of the SHARE study, David A Hinds, Norbert Hübner, Stephan Weidinger, Patrik Ke Magnusson, Eric Jorgenson, Robert Karlsson, Lavinia Paternoster, Dorret I Boomsma, Catarina Almqvist, Young-Ae Lee, Gerard H Koppelman
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008725 (2020)
Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease fir
Externí odkaz:
https://doaj.org/article/4529d4b958ea4684aa8f46663d834028
Autor:
Thomas J. Hoffmann, Michael N. Passarelli, Rebecca E. Graff, Nima C. Emami, Lori C. Sakoda, Eric Jorgenson, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Charles P. Quesenberry, Chun R. Chao, Nirupa R. Ghai, David Aaronson, Joseph Presti, Tobias Nordström, Zhaoming Wang, Sonja I. Berndt, Stephen J. Chanock, Jonathan D. Mosley, Robert J. Klein, Mridu Middha, Hans Lilja, Olle Melander, Mark N. Kvale, Pui-Yan Kwok, Catherine Schaefer, Neil Risch, Stephen K. Van Den Eeden, John S. Witte
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used
Externí odkaz:
https://doaj.org/article/90bfd13c12e74ae09f3017f178930048
Autor:
John S. Witte, Neil Risch, Catherine Schaefer, Pui-Yan Kwok, Mark N. Kvale, Daniela Seminara, Brian E. Henderson, Christopher A. Haiman, Lorelei A. Mucci, Kathryn L. Penney, Matthew L. Freedman, Qiyuan Li, Stephen N. Thibodeau, Daniel J. Schaid, Amy J. French, Shannon K. McDonnell, Stephen J. Chanock, Sonja I. Berndt, Zhaoming Wang, Joseph Presti, David Aaronson, Charles P. Quesenberry, Dilrini K. Ranatunga, Jun Shan, Nirupa R. Ghai, Chun R. Chao, Nima C. Emami, Clinton L. Cario, Michael N. Passarelli, Rebecca E. Graff, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda, Stephen K. Van Den Eeden, Thomas J. Hoffmann
Supplementary Table S1. Descriptive factors for KP study population, broken down by study. Supplementary Table S2. Genome-wide significant SNPs found in our cohort. Supplementary Table S3. Cis-eQTL expression of rs4646284. Supplementary Table S4. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b2bff2d8c86df2754f6553c7b45ff9
https://doi.org/10.1158/2159-8290.22531545
https://doi.org/10.1158/2159-8290.22531545
Autor:
John S. Witte, Stephen K. Van Den Eeden, Thomas J. Hoffmann, Neil Risch, Catherine Schaefer, Pui-Yan Kwok, Mark N. Kvale, Lori C. Sakoda, Eric Jorgenson, Nirupa R. Ghai, Chun R. Chao, Dilrini K. Ranatunga, Jun Shan, Laurel A. Habel, Joseph Presti, David Aaronson, Simon Wong, Eunice Wan, Linda Kachuri, Joel A. Mefford, Caroline G. Tai, Rebecca E. Graff, Clinton L. Cario, Sara R. Rashkin, Taylor B. Cavazos, Nima C. Emami
Figure S1-S6, Table S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3832c1cc5a2ef438ce0e17b1f933c0
https://doi.org/10.1158/0008-5472.22428541.v1
https://doi.org/10.1158/0008-5472.22428541.v1
Autor:
Wei Zheng, Rosalind A. Eeles, Christopher A. Haiman, John S. Witte, Zsofia Kote-Jarai, Matthew L. Freedman, Kathryn L. Penney, Bogdan Pasaniuc, Joshua A. Bauer, Xingyi Guo, Yingchang Lu, Xiao-Ou Shu, Jirong Long, Nima C. Emami, Taylor B. Cavazos, Qiuyin Cai, Jifeng Wang, Lang Wu
Genome-wide association study–identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58ebf7b2e6dc29d053870e11671de2
https://doi.org/10.1158/0008-5472.c.6510960.v1
https://doi.org/10.1158/0008-5472.c.6510960.v1