Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Nilson Ivo Tonin Zanchin"'
Autor:
Natália Dantas Fontes, Fernanda Lopes Habib, Leonardo Maia Leony, Natália Erdens Maron Freitas, Ângelo Antônio Oliveira Silva, Filipe Dantas-Torres, Kamila Gaudêncio da Silva Sales, Antônia Cláudia Jácome da Câmara, Vicente Toscano de Araújo-Neto, Leila Denise Alves Ferreira Amorim, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Fred Luciano Neves Santos
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Chagas disease (CD), a neglected parasitic disease caused by Trypanosoma cruzi, poses a significant health threat in Latin America and has emerged globally because of human migration. Trypanosoma cruzi infects humans and over 100
Externí odkaz:
https://doaj.org/article/ea3e856bcc5d4d0586d2062bca324563
Autor:
Renato Ferras Penteado, Renata Santana da Silva, Danielle Maria Nascimento Moura, Gustavo Barbosa de Lima, Amaranta Muniz Malvezzi, Tallyta Tâmara da Silva Monteiro, Camila Cavalcanti Xavier, Sophie Vichier-Guerre, Laurence Dugué, Sylvie Pochet, Nilson Ivo Tonin Zanchin, Christian Robson de Souza Reis, Osvaldo Pompílio de Melo Neto, Beatriz Gomes Guimarães
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Recognition of the mRNA 5′ end is a critical step needed for translation initiation. This step is performed by the cap binding protein eIF4E, which joins the larger eIF4G subunit to form the eIF4F complex. Trypanosomatids have a minimum of
Externí odkaz:
https://doaj.org/article/f7786e52a72f4a5ab2057eaf649e92ed
Autor:
Ângelo Antônio Oliveira Silva, Ayla Araújo Lima, Larissa Carvalho Medrado Vasconcelos, Rosângela Andrade Almeida, Natália Erdens Maron Freitas, Talita Andrade Oliva, Miralba Freire de Carvalho Ribeiro da Silva, Fabricio Klerynton Marchini, Nilson Ivo Tonin Zanchin, Isadora Cristina de Siqueira, Fred Luciano Neves Santos
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Syphilis is a sexually transmitted infection (STI) caused by the spiral bacterium Treponema pallidum. Diagnosis is based on epidemiology, clinical and serology, but serodiagnosis is challenging because distinct clinical forms of the infection may inf
Externí odkaz:
https://doaj.org/article/048639def9d24698a6b4004be968dc80
Autor:
Eloise Pavão Guerra-Slompo, Gisele Fernanda Assine Picchi-Constante, Martin Marek, Christophe Romier, Wolfgang Sippl, Nilson Ivo Tonin Zanchin
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102058- (2023)
Summary: Here, we describe a combined in cellulo and in vivo approach to identify compounds with higher potential for efficient inhibition of Trypanosoma cruzi. Phase I of in cellulo assays is designed to exclude inactive or toxic compounds, while ph
Externí odkaz:
https://doaj.org/article/a6ce12f930fd45ce85f6f3a2270026cc
A toolkit for recombinant production of seven human EGF family growth factors in active conformation
Autor:
Arthur Schveitzer Ferreira, Amanda Lopacinski, Michel Batista, Priscila Mazzocchi Hiraiwa, Beatriz Gomes Guimarães, Nilson Ivo Tonin Zanchin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Epidermal growth factors (EGF) play a wide range of roles in embryogenesis, skin development, immune response homeostasis. They are involved in several pathologies as well, including several cancer types, psoriasis, chronic pain and chronic
Externí odkaz:
https://doaj.org/article/9c5595329906401380177b387bb77545
Autor:
Neci Matos Soares, Nilo Manoel Pereira Vieira Barreto, Marina Morena Brito Farias, Cíntia de Lima Oliveira, Weslei Almeida Costa Araújo, Joelma Nascimento de Souza, Márcia Cristina Aquino Teixeira, Noilson Lázaro Sousa Gonçalves, Daniel Dias Sampaio, Tycha Bianca Sabaini Pavan, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Fred Luciano Neves Santos
Publikováno v:
Pathogens, Vol 12, Iss 10, p 1222 (2023)
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a neglected tropical disease with life-threatening implications. In this study, we conducted a seroepidemiological survey to determine the prevalence and clinical profiles of CD in 217
Externí odkaz:
https://doaj.org/article/8f97d73e86c5406faa60aab7d380c98a
Autor:
Gisele Fernanda Assine Picchi-Constante, Eloise Pavão Guerra-Slompo, Ana Carolina Tahira, Monica Visnieski Alcantara, Murilo Sena Amaral, Arthur Schveitzer Ferreira, Michel Batista, Cassiano Martin Batista, Samuel Goldenberg, Sergio Verjovski-Almeida, Nilson Ivo Tonin Zanchin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Trypanosoma cruzi—the causative agent of Chagas disease—like other kinetoplastids, relies mostly on post-transcriptional mechanisms for regulation of gene expression. However, trypanosomatids undergo drastic changes in nuclear architectu
Externí odkaz:
https://doaj.org/article/096465a371e64559b0aaba9b89558b88
Autor:
Ramona Tavares Daltro, Emily Ferreira Santos, Ângelo Antônio Oliveira Silva, Natália Erdens Maron Freitas, Leonardo Maia Leony, Larissa Carvalho Medrado Vasconcelos, Alejandro Ostermayer Luquetti, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Carlos Gustavo Regis-Silva, Fred Luciano Neves Santos
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010944 (2022)
BackgroundChagas disease (CD) is caused by Trypanosoma cruzi. The chronic phase of CD is characterized by the presence of IgG anti-T. cruzi antibodies; and diagnosis is performed by serological methods. Because there is no reliable test that can be u
Externí odkaz:
https://doaj.org/article/295fa772dea74cf4bd50408f795512a6
Autor:
Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101324- (2022)
Summary: This protocol outlines a new genetic complementation strategy to investigate gene function in Trypanosoma cruzi, the parasite causing Chagas disease. We combine CRISPR-Cas9 technology with recombination of variants of the target gene contain
Externí odkaz:
https://doaj.org/article/5233e0e1faa14a838c7f1926e6da97ab
Autor:
Emily Ferreira dos Santos, Ângelo Antônio Oliveira Silva, Natália Erdens Maron Freitas, Leonardo Maia Leony, Ramona Tavares Daltro, Carlos Antônio de Souza Teles Santos, Maria da Conceição Chagas de Almeida, Fernando Luiz Vieira de Araújo, Paola Alejandra Fiorani Celedon, Marco Aurélio Krieger, Nilson Ivo Tonin Zanchin, Mitermayer Galvão dos Reis, Fred Luciano Neves Santos
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Chagas disease (CD) is among the top 10 causes of inability to blood donation. Blood donation centers screen for anti-Trypanosoma cruzi antibodies using highly sensitive immunoenzymatic (ELISA) or chemiluminescent methods, which can lead to false pos
Externí odkaz:
https://doaj.org/article/4dc87bbf38d143adb994f3ee6d99e25c