Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nilsa La Cunza"'
Autor:
Nilsa La Cunza, Li Xuan Tan, Thushara Thamban, Colin J. Germer, Gurugirijha Rathnasamy, Kimberly A. Toops, Aparna Lakkaraju
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE), the tissue that safeguards photoreceptor health, leading to irreversible vision loss. Polymorphisms in cholesterol and complement genes are implicated in AMD, yet me
Externí odkaz:
https://doaj.org/article/202e6224fce449b28b35804cd08cb9a3
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101781- (2020)
The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD. Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD,
Externí odkaz:
https://doaj.org/article/06512f1fd3204c9eb45cd9a89d51fb42
Autor:
Colin J. Germer, Thushara Thamban, Aparna Lakkaraju, Nilsa La Cunza, Kimberly A. Toops, Gurugirijha Rathnasamy, Li Xuan Tan
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE), the tissue that safeguards photoreceptor health, leading to irreversible vision loss. Polymorphisms in cholesterol and complement genes are implicated in AMD, yet me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d923b8736bb6fd1603ce75ff1954ae31
https://doi.org/10.1172/jci.insight.142254
https://doi.org/10.1172/jci.insight.142254
Autor:
Kimberly A. Toops, Nilsa La Cunza, Li Xuan Tan, Timothy A. Blenkinsop, Aparna Lakkaraju, Colin J. Germer, Gulpreet Kaur, Marie Fernandes, Gurugirijha Rathnasamy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 36
Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f57111e78cb037d16a194526fd8ee99
https://doi.org/10.1073/pnas.1805039115
https://doi.org/10.1073/pnas.1805039115
Publikováno v:
Redox Biology
Redox Biology, Vol 37, Iss, Pp 101781-(2020)
Redox Biology, Vol 37, Iss, Pp 101781-(2020)
The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD. Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dd8b95220e27b3a9d2253622bb8161
https://doi.org/10.1016/j.redox.2020.101781
https://doi.org/10.1016/j.redox.2020.101781
Autor:
Diane M. Simeone, Theresa M. Keeley, Angeliki Louvi, Linda C. Samuelson, Jason R. Spence, Andrew H Tam, Nilsa La Cunza, Ichiko Saotome, Gail B. Gifford, Priya H. Dedhia, Christian W. Siebel, Elise S. Demitrack
Publikováno v:
Gut. 66(6)
Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design Mice were treated with the pan-Notch inhibitor dibenzazepine (DBZ) or inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00379206566f17d6bb11bf3ef01bf71b
https://pubmed.ncbi.nlm.nih.gov/26933171
https://pubmed.ncbi.nlm.nih.gov/26933171