Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Nils. J. Færgeman"'
Autor:
Kevin H. Nygaard, Jesper F. Havelund, Troels H. Nielsen, Carl-Henrik Nordström, Nils. J. Færgeman, Frantz R. Poulsen, Jan Bert Gramsbergen, Axel Forsse
Publikováno v:
Metabolites, Vol 10, Iss 7, p 287 (2020)
Mitochondrial dysfunction after transient cerebral ischemia can be monitored by cerebral microdialysis (CMD) using changes in the lactate and pyruvate concentrations and ratio. Other metabolites associated with mitochondrial (dys)function are, e.g.,
Externí odkaz:
https://doaj.org/article/b95c25fe168148e28870d57fd8d847f1
Autor:
Jesper F. Havelund, Kevin H. Nygaard, Troels H. Nielsen, Carl-Henrik Nordström, Frantz R. Poulsen, Nils. J. Færgeman, Axel Forsse, Jan Bert Gramsbergen
Publikováno v:
Metabolites, Vol 9, Iss 10, p 204 (2019)
Cerebral micro-dialysis allows continuous sampling of extracellular metabolites, including glucose, lactate and pyruvate. Transient ischemic events cause a rapid drop in glucose and a rise in lactate levels. Following such events, the lactate/pyruvat
Externí odkaz:
https://doaj.org/article/56d8a78649124aa99f1b645961a14725
Autor:
Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Havelund, Arnaud Stigliani, Nils J. Færgeman, Audrey Prézelin, Julie Rivière, Anne Couturier-Tarrade, Vyacheslav Akimov, Blagoy Blagoev, Betina Elfving, Ditte Neess, Ulla Vogel, Konstantin Khodosevich, Karin Sørig Hougaard, Albin Sandelin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lu
Externí odkaz:
https://doaj.org/article/f27ea51dbf684c569e6842c66b46c497
Autor:
Ulrika Simone Spangsberg Petersen, Maja Dembic, Ainhoa Martínez-Pizarro, Eva Richard, Lise Lolle Holm, Jesper Foged Havelund, Thomas Koed Doktor, Martin Røssel Larsen, Nils J. Færgeman, Lourdes Ruiz Desviat, Brage Storstein Andresen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102101- (2024)
Pseudoexons are nonfunctional intronic sequences that can be activated by deep-intronic sequence variation. Activation increases pseudoexon inclusion in mRNA and interferes with normal gene expression. The PCCA c.1285-1416A>G variation activates a ps
Externí odkaz:
https://doaj.org/article/ff8b723093454117929845437197aef9
Autor:
Ditte Neess, Vibeke Kruse, Ann-Britt Marcher, Mie Rye Wæde, Julie Vistisen, Pauline M. Møller, Rikke Petersen, Jonathan R. Brewer, Tao Ma, Georgia Colleluori, Ilenia Severi, Saverio Cinti, Zach Gerhart-Hines, Susanne Mandrup, Nils J. Færgeman
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101144- (2021)
Objectives: The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological respo
Externí odkaz:
https://doaj.org/article/1804191abfef4a3bb04c6cbbccd5ca3f
Autor:
Muriel G M D Almeida, Daniela S Arêdes, David Majerowicz, Nils J Færgeman, Jens Knudsen, Katia C Gondim
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227685 (2020)
The acyl-CoA-binding proteins (ACBP) act by regulating the availability of acyl-CoA in the cytoplasm and must have essential functions in lipid metabolism. The genome of the kissing-bug Rhodnius prolixus encodes five proteins of this family, but litt
Externí odkaz:
https://doaj.org/article/d94e954ad6594513b2fa7dc75b2b409c
Autor:
Julia Bandres-Meriz, Christina Kunz, Jesper F. Havelund, Nils J. Færgeman, Alejandro Majali-Martinez, Regina Ensenauer, Gernot Desoye
Publikováno v:
International Journal of Obesity.
Background/Objectives Obesity in pregnancy associates with changes in the glucose-insulin axis. We hypothesized that these changes affect the maternal metabolome already in the first trimester of human pregnancy and, thus, aimed to identify these met
Autor:
Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines
Publikováno v:
Basse, A L, Nielsen, K N, Karavaeva, I, Ingerslev, L R, Ma, T, Havelund, J F, Nielsen, T S, Frost, M, Peics, J, Dalbram, E, Dall, M, Zierath, J R, Barrès, R, Færgeman, N J, Treebak, J T & Gerhart-Hines, Z 2023, ' NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 14, e2220102120 . https://doi.org/10.1073/pnas.2220102120
Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD + , which os
Autor:
Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Havelund, Nils J. Færgeman, Audrey Prézelin, Julie Rivière, Anne Couturier-Tarrade, Vyacheslav Akimov, Blagoy Blagoev, Betina Elfving, Arnaud Stigliani, Ulla Birgitte Vogel, Konstantin Khodosevich, Karin Sørig Hougaard, Albin Sandelin
Maternal immune system activation (MIA) during pregnancy can disrupt the fetal environment, causing postnatal susceptibility to disorders. How the placenta and the fetus respond to acute MIA over time is unknown. Here, we characterized the response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6492259e1052fbd35457071fad0f91a2
https://doi.org/10.1101/2023.03.17.532052
https://doi.org/10.1101/2023.03.17.532052
Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP−/− mice[S]
Autor:
Signe Bek, Ditte Neess, Karen Dixen, Maria Bloksgaard, Ann-Britt Marcher, John Chemnitz, Nils J. Færgeman, Susanne Mandrup
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 9, Pp 1738-1746 (2015)
Acyl-CoA binding protein (ACBP) is a small, ubiquitously expressed intracellular protein that binds C14-C22 acyl-CoA esters with very high affinity and specificity. We have recently shown that targeted disruption of the Acbp gene leads to a compromis
Externí odkaz:
https://doaj.org/article/a3d4a252a6e045858a0556c3d040eebe