Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Nils-Gunnar Johansson"'
Autor:
Guiomar Pérez-Moreno, Paula Sánchez-Carrasco, Luis Miguel Ruiz-Pérez, Nils Gunnar Johansson, Sylke Müller, Beatriz Baragaña, Shahienaz Emma Hampton, Ian Hugh Gilbert, Marcel Kaiser, Sandipan Sarkar, Thiyagamurthy Pandurangan, Vijeesh Kumar, Dolores González-Pacanowska
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-m
Externí odkaz:
https://doaj.org/article/a40f1ef15b204c75a6f032176c445e23
Autor:
Justin R, Harrison, Sandipan, Sarkar, Shahienaz, Hampton, Jennifer, Riley, Laste, Stojanovski, Christer, Sahlberg, Pia, Appelqvist, Jessey, Erath, Vinodhini, Mathan, Ana, Rodriguez, Marcel, Kaiser, Dolores Gonzalez, Pacanowska, Kevin D, Read, Nils Gunnar, Johansson, Ian H, Gilbert
Publikováno v:
Journal of medicinal chemistry. 63(6)
Chagas disease is caused by the protozoan parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3be7b1a0700258bb2e44498c433ca4e
https://pubmed.ncbi.nlm.nih.gov/32134269
https://pubmed.ncbi.nlm.nih.gov/32134269
Autor:
Marcel Kaiser, Justin R. Harrison, Vinodhini Mathan, Sandipan Sarkar, Ian H. Gilbert, Laste Stojanovski, Christer Sahlberg, Jennifer Riley, Ana Rodriguez, Nils Gunnar Johansson, Pia Appelqvist, Jessey Erath, Dolores Gonzalez Pacanowska, Shahienaz E. Hampton, Kevin D. Read
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e827355cb5490d1a755ca354b64d4ab
http://hdl.handle.net/10261/216294
http://hdl.handle.net/10261/216294
Autor:
Vijeesh Kumar, Thiyagamurthy Pandurangan, Sylke Müller, Shahienaz E. Hampton, Luis M. Ruiz-Pérez, Beatriz Baragaña, Dolores González-Pacanowska, Ian H. Gilbert, Sandipan Sarkar, Guiomar Pérez-Moreno, Paula Sánchez-Carrasco, Nils Gunnar Johansson, Marcel Kaiser
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Malaria Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Malaria Journal
[Background] Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-malarial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d1096df0067e37cdca0b33280d7c3b
https://edoc.unibas.ch/73555/
https://edoc.unibas.ch/73555/
Autor:
Krzysztof Felczak, Gian Filippo Ruda, Ganasan Kasinathan, Reto Brun, Marcel Kaiser, Luis M. Ruiz-Pérez, Nils Gunnar Johansson, Xiao Xiong Zhou, Dolores González-Pacanowska, Corinne Nguyen, Ian H. Gilbert, Tadeusz Kulikowski, Christian Sund, Alexander Musso-Buendia, Przemysław Ziemkowski
Publikováno v:
ChemMedChem. 6:309-320
2'-Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d96195d754b423ee21ccddda7540297
https://doi.org/10.1002/cmdc.201000445
https://doi.org/10.1002/cmdc.201000445
Autor:
Xiao-Xiong Zhou, Mark D. Smith, Hans Maag, David Bernard Smith, Isabel Najera, Genadiy Kalayanov, Sophie Le Pogam, Tatiana Maltseva, Vincent Leveque, Ann C. Kaiser, Kurt Benkestock, Anna Winqvist, Nils Gunnar Johansson, Steven Swallow, Sonal Rajyaguru, Joseph A. Martin, Christian Sund, Nick Cammack, Klaus Klumpp
Publikováno v:
Journal of Medicinal Chemistry. 52:2971-2978
The discovery of 4'-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC(50) = 1.28 microM), the RNA polymerase encoded by hepatitis C virus (HCV), has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9589d3f6f4bd14d1b10c52db9adbe31a
https://doi.org/10.1021/jm801595c
https://doi.org/10.1021/jm801595c
Autor:
Marcel Kaiser, Dolores Gonzalez Pacanowska, Alex Musso-Buendia, Ian H. Gilbert, Reto Brun, Luis M. Ruiz-Pérez, Orla McCarthy, Nils Gunnar Johansson
Publikováno v:
European Journal of Medicinal Chemistry. 44:678-688
The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa649aa56dd3e77e9489983621f973b0
https://doi.org/10.1016/j.ejmech.2008.05.018
https://doi.org/10.1016/j.ejmech.2008.05.018
Autor:
Corinne Nguyen, Isabel Leal, Dolores González-Pacanowska, Britt-Louise Sahlberg, Alessandro Schipani, Luis M Ruiz-Pérez, Nils Gunnar Johansson, Ian H. Gilbert, Alexander Musso-Buendia, Marcel Kaiser, Ganasan Kasinathan, Gian Filippo Ruda, Reto Brun
Publikováno v:
Journal of Medicinal Chemistry. 49:4183-4195
We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been identified as a promising target for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71bba426ce4e5a34a71b03d41dc1c34
https://doi.org/10.1021/jm060126s
https://doi.org/10.1021/jm060126s
Publikováno v:
Chemistry of Heterocyclic Compounds. 32:1312-1318
A series pf 5-aryl-2′-deoxyuridines has been prepared and evaluated as antiviral agents. The following substituents have been used in position 3 of the phenyl ring: chloro, iodo, amino, azido, methylthio, and vinyl. None of the new compounds showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2e3b9809705d858d94bf43d1a9ed5d
https://doi.org/10.1007/bf01169963
https://doi.org/10.1007/bf01169963
Publikováno v:
Nucleosides and Nucleotides. 15:1059-1076
Dicarboxylic acid 5′-monoesters of thymidine and 5-(2-thienyl)-2′′-deoxyuridine have been synthesised and evaluated as triphosphate mimics. Glutaric (25, 29), adipic (26, 30), pimelic (27, 31) and trans-1,4-cyclohexane dicarboxylic acids (28, 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ef39c53045a0d43918463964856d59
https://doi.org/10.1080/07328319608002034
https://doi.org/10.1080/07328319608002034