Výsledky vyhledávání - "Nils Tore, Vethe"

Akademický článek

Mevalonate in blood and muscle: Response to atorvastatin treatment and the relationship to statin intolerance in patients with coronary heart disease

Autor: Trine Lauritzen, John Munkhaugen, Stein Bergan, Elise Sverre, Kari Peersen, Sofia Lindahl, Einar Husebye, Nils Tore Vethe

Publikováno v: Clinical and Translational Science, Vol 17, Iss 10, Pp n/a-n/a (2024)

Abstract Statin‐associated muscle symptoms are frequently reported and often lead to discontinuation of statin therapy with an increased risk of cardiovascular events. In vitro studies suggest that statin‐mediated inhibition of the mevalonate pat

Externí odkaz: https://doaj.org/article/5b65608158ed44b3a3a0003acb6a99f0

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Akademický článek

The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study

Autor: Trine Lauritzen, John Munkhaugen, Stein Bergan, Kari Peersen, Anja Camilla Svarstad, Anders M. Andersen, Jens Pahnke, Einar Husebye, Nils Tore Vethe

Publikováno v: Atherosclerosis Plus, Vol 55, Iss , Pp 31-38 (2024)

Background and aims: Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It is challenging and time-consuming for clinicians to assess whether symptoms are caused by the statin or not, and diagnostic biomarkers ar

Externí odkaz: https://doaj.org/article/f98394738ee04db2a3ec9c22ef5ac108

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Akademický článek

Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects

Autor: Kari Peersen, John Munkhaugen, Elise Sverre, Oscar Kristiansen, Morten Fagerland, Nils Tore Vethe, Joep Perk, Einar Husebye, Toril Dammen

Publikováno v: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-9 (2021)

Abstract Background To compare clinical and psychological factors among patients with self-perceived statin-associated muscle symptoms (SAMS), confirmed SAMS, and refuted SAMS in coronary heart disease patients (CHD). Methods Data were obtained from

Externí odkaz: https://doaj.org/article/2fd685e366b148b7b0a08325c2da3665

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Atorvastatin Metabolite Pattern in Skeletal Muscle and Blood from Patients with Coronary Heart Disease and Statin‐Associated Muscle Symptoms

Autor: Trine Lauritzen, John Munkhaugen, Kari Peersen, Oscar Kristiansen, Elise Sverre, Shane D. Nebauer, Maja Villseth, Anders M. Andersen, Anja Camilla Svarstad, Elena Prunés Jensen, Stein Bergan, Einar Husebye, Nils Tore Vethe

Publikováno v: Clinical Pharmacology & Therapeutics. 113:887-895

Self-perceived statin-associated muscle symptoms (SAMS) are prevalent, but only a minority is drug-dependent. Diagnostic biomarkers are not yet identified. The local statin exposure in skeletal muscle tissue may correlate to the adverse effects. We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aaadb7d00300679a1cba269bfa49376
https://doi.org/10.1002/cpt.2844

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Monitoring Simvastatin Adherence in Patients With Coronary Heart Disease: A Proof-of-Concept Study Based on Pharmacokinetic Measurements in Blood Plasma

Autor: Nils Tore, Vethe, Einar, Husebye, Anders M, Andersen, Stein, Bergan, Oscar, Kristiansen, Morten W, Fagerland, John, Munkhaugen

Publikováno v: Therapeutic Drug Monitoring. 44:558-567

Poor statin adherence remains a public health concern associated with adverse outcomes. We evaluated the use of pharmacokinetic measurements to monitor adherence to simvastatin in patients with coronary heart disease (CHD).Eighteen patients with CHD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3cd0b8bc739c22887a24b5fc3eba5
https://doi.org/10.1097/ftd.0000000000000992

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Akademický článek

Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells

Autor: Marcus Bergström, Malin Müller, Marie Karlsson, Hanne Scholz, Nils Tore Vethe, Olle Korsgren

Publikováno v: Cell Transplantation, Vol 28 (2019)

Adoptive transfer of autologous polyclonal regulatory T cells (Tregs) is a promising option for reducing graft rejection in allogeneic transplantation. To gain therapeutic levels of Tregs there is a need to expand obtained cells ex vivo, usually in t

Externí odkaz: https://doaj.org/article/a8d91b6101374785b97a8bea5df9d8d0

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Prednisolone and Prednisone Pharmacokinetics in Adult Renal Transplant Recipients

Autor: Ragnhild Heier Skauby, Marte Theie Gustavsen, Anders Mikal Andersen, Anna Bjerre, Nils Tore Vethe, Anders Åsberg, Karsten Midtvedt, Stein Bergan

Publikováno v: Therapeutic Drug Monitoring. 43:247-255

BACKGROUND Prednisolone (PL) is a standard component of most immunosuppressive protocols after solid organ transplantation (Tx). Adverse effects are frequent and well known. The aim of this study was to characterize the pharmacokinetics (PKs) of PL a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac1999366031a2dfd033d97cbb8cf4c
https://doi.org/10.1097/ftd.0000000000000835

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Clinical and pharmacological characteristics in plasma and mononuclear blood cells in patients with coronary heart disease and low statin tolerance

Autor: T Lauritzen, JM John Munkhaugen, KP Kari Peersen, ES Elise Sverre, OK Oscar Kristiansen, EPJ Elena Prunes Jensen, SB Stein Bergan, EH Einar Husebye, NTV Nils Tore Vethe

Publikováno v: European Journal of Preventive Cardiology. 29

Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Vestre Viken Hospital Trust Background Statin-associated muscle symptoms (SAMS) cover a broader range of clinical presentations, with normal or mildly eleva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec322ebea85d14dde97bf84be4dcfefd
https://doi.org/10.1093/eurjpc/zwac056.177

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Measuring Intracellular Concentrations of Calcineurin Inhibitors

Autor: Nils Tore Vethe, Ida Robertsen, Brenda C. M. de Winter, Birgit C. P. Koch, Mercè Brunet, Pierre Wallemacq, Florian Lemaitre, Amedeo Denicolo, Teun van Gelder, Dennis A. Hesselink, Stein Bergan, Raman Venkataramanan, Antonio D'Avolio, Camille Tron

Publikováno v: Therapeutic Drug Monitoring, 42(5), 665-670. Lippincott Williams & Wilkins
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2020, 42 (5), pp.665-670. ⟨10.1097/FTD.0000000000000780⟩
Therapeutic Drug Monitoring, 2020, 42 (5), pp.665-670. ⟨10.1097/FTD.0000000000000780⟩

Background Therapeutic drug monitoring (TDM) of the two calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporine A (CsA), has resulted in improvements in the management of patients who have undergone solid organ transplantation. As a result o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87e88101c001e9e0bbcfecc6db7505c
https://doi.org/10.1097/ftd.0000000000000780

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