Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nils R. Hansmeier"'
Autor:
René Hägerling, Malou Van Zanten, Rose Yinghan Behncke, Sascha Ulferts, Nils R. Hansmeier, Bruno Märkl, Christian Witzel, Bernard Ho, Vaughan Keeley, Katie Riches, Sahar Mansour, Kristiana Gordon, Pia Ostergaard, Peter S. Mortimer
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Superficial erythematous cutaneous vascular malformations are assumed to be blood vascular in origin, but cutaneous lymphatic malformations can contain blood and appear red. Management may be different and so an accurate diagnosis is important. Cutan
Externí odkaz:
https://doaj.org/article/90a5b5d07dcd49ba99efb501fc892bb3
Autor:
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepat
Externí odkaz:
https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
Autor:
Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Ørom, Jörg Heeren, Matthias Blüher, Martin Bilban, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA,
Externí odkaz:
https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d
Publikováno v:
Non-Coding RNA, Vol 5, Iss 1, p 12 (2019)
In recent years, long noncoding RNAs (lncRNAs) have emerged as multifaceted regulators of gene expression, controlling key developmental and disease pathogenesis processes. However, due to the paucity of lncRNA loss-of-function mouse models, key ques
Externí odkaz:
https://doaj.org/article/f804dd4eaf644ae7a8d9abf9fe522315
Autor:
Felix Boschann, Ozgur Cogulu, Davut Pehlivan, Saranya Balachandran, Pedro Vallecillo-Garcia, Christopher M. Grochowski, Nils R. Hansmeier, Zeynep H. Coban Akdemir, Cesar A. Prada-Medina, Ayca Aykut, Björn Fischer-Zirnsak, Simon Badura, Burak Durmaz, Ferda Ozkinay, René Hägerling, Jennifer E. Posey, Sigmar Stricker, Gabriele Gillessen-Kaesbach, Malte Spielmann, Denise Horn, Knut Brockmann, James R. Lupski, Uwe Kornak, Julia Schmidt
Publikováno v:
GENETICS IN MEDICINE
Purpose: We aimed to identify the underlying genetic cause for a novel form of distal arthrogryposis. Methods: Rare variant family-based genomics, exome sequencing, and disease-specific panel sequencing were used to detect ADAMTS15 variants in affect
Autor:
Hande Topel, Hildegard Büning, Peter A. Edwards, Peter Frommolt, Jan-Wilhelm Kornfeld, Bjørk Ditlev Larsen, Igor Ulitsky, Dario F. De Jesus, Ines Dhaouadi, Elena Schmidt, Robin Schwarzer, Rohit N. Kulkarni, Richard G. Lee, Ling Yang, Haiming Cao, Nils R. Hansmeier, Christoph A. Kiefer, Thomas Q. de Aguiar Vallim, Sajjad Khani, Branko Zevnik, Rute Loureiro, Christoph Dieterich, Jenny C. Link, Ludger Scheja, Matteo Oliverio, Motoharu Awazawa, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Masayuki Yamamoto, Simon E. Tröder, Nicola Meola, Paul Klemm, Joerg Heeren, Uwe Knippschild, Markus Heine
Publikováno v:
Pradas-Juni, M, Hansmeier, N R, Link, J C, Schmidt, E, Larsen, B D, Klemm, P, Meola, N, Topel, H, Loureiro, R, Dhaouadi, I, Kiefer, C A, Schwarzer, R, Khani, S, Oliverio, M, Awazawa, M, Frommolt, P, Heeren, J, Scheja, L, Heine, M, Dieterich, C, Büning, H, Yang, L, Cao, H, Jesus, D F D, Kulkarni, R N, Zevnik, B, Tröder, S E, Knippschild, U, Edwards, P A, Lee, R G, Yamamoto, M, Ulitsky, I, Fernandez-Rebollo, E, Vallim, T Q D A & Kornfeld, J-W 2020, ' A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism ', Nature Communications, vol. 11, no. 1, 644 . https://doi.org/10.1038/s41467-020-14323-y
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed d
Autor:
Hella S. Brönneke, Emilio Tarcitano, Markus Heine, Peter Frommolt, Nils R. Hansmeier, Trieu-My Van, Marta Pradas-Juni, Jan Mauer, George A. Garinis, Deniz Bartsch, Sajjad Khani, Susanne Brodesser, Catherina Baitzel, Matteo Oliverio, Marcelo A. Mori, Elena Schmidt, Jens C. Brüning, Hans Hilpert, Sandra Konieczka, Jan-Wilhelm Kornfeld, Jörg Heeren
Publikováno v:
Nature Cell Biology. 18:328-336
Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfuncti
Autor:
Nils R. Hansmeier, Marta Pradas-Juni, Matteo Oliverio, Isabella Gaziano, Eduardo Fernandez-Rebollo, Gerfried Mitterer, Jan-Wilhelm Kornfeld, Markus Heine, Martin Bilban, Christoph A. Kiefer, Sajjad Khani, Jörg Heeren, Peter Zentis, Ines Dhaouadi, Philipp Hammerschmidt, Matthias Blüher, Rute Loureiro, Wolfgang Wagner, Ulf Andersson Ørom, Peter Frommolt, Matteo Bergami, Evgenia Ntini, Paul Klemm, Motoharu Awazawa, Elena Schmidt
Publikováno v:
Schmidt, E, Dhaouadi, I, Gaziano, I, Oliverio, M, Klemm, P, Awazawa, M, Mitterer, G, Fernandez-Rebollo, E, Pradas-Juni, M, Wagner, W, Hammerschmidt, P, Loureiro, R, Kiefer, C, Hansmeier, N R, Khani, S, Bergami, M, Heine, M, Ntini, E, Frommolt, P, Zentis, P, Ørom, U A, Heeren, J, Blüher, M, Bilban, M & Kornfeld, J W 2018, ' LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat ', Nature Communications, vol. 9, no. 1, 3622 . https://doi.org/10.1038/s41467-018-05933-8
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications 9, 3622 (2018). doi:10.1038/s41467-018-05933-8
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications 9, 3622 (2018). doi:10.1038/s41467-018-05933-8
Nature Communications
Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes re
Publikováno v:
Non-Coding RNA, Vol 5, Iss 1, p 12 (2019)
Non-Coding RNA
Hansmeier, N R, Widdershooven, P J M, Khani, S & Kornfeld, J-W 2019, ' Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology ', Non-Coding R N A, vol. 5, no. 1, 12, pp. 1-12 . https://doi.org/10.3390/ncrna5010012
Volume 5
Issue 1
Non-Coding RNA
Hansmeier, N R, Widdershooven, P J M, Khani, S & Kornfeld, J-W 2019, ' Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology ', Non-Coding R N A, vol. 5, no. 1, 12, pp. 1-12 . https://doi.org/10.3390/ncrna5010012
Volume 5
Issue 1
In recent years, long noncoding RNAs (lncRNAs) have emerged as multifaceted regulators of gene expression, controlling key developmental and disease pathogenesis processes. However, due to the paucity of lncRNA loss-of-function mouse models, key ques