Silencing of spontaneous activity at α4β1/3δ GABA A receptors in hippocampal granule cells reveals different ligand pharmacology

Autor: Nils Ole Dalby, Bente Frølund, Ulrike Leurs, Petrine Wellendorph, Christina Birkedahl Falk-Petersen, Petra Scholze, Jacob Krall

Publikováno v: British Journal of Pharmacology. 177:3975-3990

Background and purpose The δ-subunit-containing GABAA receptors, α4 β1 δ and α4 β3 δ, in dentate gyrus granule cells (DGGCs) are known to exhibit both spontaneous channel openings (i.e. constitutive activity) and agonist-induced current. The f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1de24ffebfdf465328982524374968a
https://doi.org/10.1111/bph.15146

GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

Autor: Nina B Johansen, Maria Ek Lie, Andrew N. Clarkson, Nils Ole Dalby, Petrine Wellendorph, Emma K. Gowing, Louise Thiesen

Publikováno v: Lie, M E, Gowing, E K, Johansen, N B, Dalby, N O, Thiesen, L, Wellendorph, P & Clarkson, A N 2019, ' GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 1, pp. 74-88 . https://doi.org/10.1177/0271678X17744123

Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits required for recovery. This stroke-induced increase in tonic inhibition is caused by impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6708d7700e6955532d036687fb4e09
https://doi.org/10.1177/0271678x17744123

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

Autor: Torben J. Hausrat, Sören Doose, Kristian Strømgaard, Matthias Kneussel, Franziska Neubert, Nils Ole Dalby, Hans Michael Maric, Markus Sauer

Publikováno v: Nature Chemical Biology. 13:153-160

γ-Aminobutyric acid type A and glycine receptors are the major mediators of fast synaptic inhibition in the human central nervous system and are established drug targets. However, all drugs targeting these receptors bind to the extracellular ligand-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e6562c2296b49961c358c8fbfefe5e
https://doi.org/10.1038/nchembio.2246

Kinase activity simultaneously determines the constitutive and the orthosteric gating in α4β1/3δ GABAA receptors in hippocampal granule cells

Autor: Christina Birkedahl Falk-Petersen, Ulrike Leurs, Nils Ole Dalby, Petrine Wellendorph, Bente Frølund, Petra Scholze, Jacob Krall

A subset of the GABAA receptors expressed in recombinant systems and neurons is known to exhibit both constitutive- and agonist-induced gating. Two such receptors are the δ-subunit containing GABAA receptors α4β1δ and α4β3δ, which are expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5b115118ff2f8d27f0af7cf1f87ab5

Feasibility and resolution limits of opto-magnetic imaging of neuralnetwork activity in brain slices using color centers in diamond

Autor: Adam M. Wojciechowski, Mürsel Karadas, Ulrik L. Andersen, Alexander Huck, Axel Thielscher, Nils Ole Dalby

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Karadas, M, Wojciechowski, A M, Huck, A, Dalby, N O, Andersen, U L & Thielscher, A 2018, ' Feasibility and resolution limits of opto-magnetic imaging of neural network activity in brain slices using color centers in diamond ', Scientific Reports, vol. 8, no. 1, 4503 . https://doi.org/10.1038/s41598-018-22793-w
Karadas, M, Wojciechowski, A M, Huck, A, Dalby, N O, Andersen, U L & Thielscher, A 2018, ' Feasibility and resolution limits of opto-magnetic imaging of neural network activity in brain slices using color centers in diamond ', Scientific Reports, vol. 8, no. 1 . https://doi.org/10.1038/s41598-018-22793-w
Scientific Reports

We suggest a novel approach for wide-field imaging of the neural network dynamics of brain slices that uses highly sensitivity magnetometry based on nitrogen-vacancy (NV) centers in diamond. In-vitro recordings in brain slices is a proven method for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f91aaf569cd10a8b9aadbbf188d3d1
https://ruj.uj.edu.pl/xmlui/handle/item/69892