Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nils Neuenkirchen"'
Autor:
Henrik Gross, Christine Hennard, Ilias Masouris, Christian Cassel, Stephanie Barth, Ute Stober-Grässer, Alfredo Mamiani, Bodo Moritz, Dirk Ostareck, Antje Ostareck-Lederer, Nils Neuenkirchen, Utz Fischer, Wen Deng, Heinrich Leonhardt, Elfriede Noessner, Elisabeth Kremmer, Friedrich A Grässer
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42106 (2012)
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs. Its Arginine-Glycine (RG) repeat elemen
Externí odkaz:
https://doaj.org/article/8b617abb322e48488118787c03063a63
Autor:
Prajwal C Boddu, Abhishek Gupta, Rahul Roy, Barbara De La Pena Avalos, Ane Olazabal Herrero, Nils Neuenkirchen, Josh Zimmer, Namrata Chandhok, Darren King, Yashuhito Nannya, Seishi Ogawa, Haifan Lin, Matthew Simon, Eloise Dray, Gary Kupfer, Amit K. Verma, Karla M. Neugebauer, Manoj M Pillai
Publikováno v:
bioRxiv
Transcription and splicing of pre-messenger RNA are closely coordinated, but how this functional coupling is disrupted in human disease remains unexplored. Here, we investigated the impact of non-synonymous mutations in SF3B1 and U2AF1, two commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc52bc1a58f7506bad42b4fd807506b
https://europepmc.org/articles/PMC9994134/
https://europepmc.org/articles/PMC9994134/
Autor:
Shilpita Karmakar, Oscar Ramirez, Kiran V Paul, Abhishek K Gupta, Vandana Kumari, Valentina Botti, Igor Ruiz de los Mozos, Nils Neuenkirchen, Robert J Ross, John Karanicolas, Karla M Neugebauer, Manoj M Pillai
Publikováno v:
NAR Cancer. 4
Musashi 2 (MSI2) is an RNA binding protein (RBP) that regulates asymmetric cell division and cell fate decisions in normal and cancer stem cells. MSI2 appears to repress translation by binding to 3′ untranslated regions (3′UTRs) of mRNA, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0594b43d2bc838dfc38b478a6467383
https://doi.org/10.1093/narcan/zcac015
https://doi.org/10.1093/narcan/zcac015
Autor:
Giulia Biancon, Poorval Joshi, Joshua T. Zimmer, Torben Hunck, Yimeng Gao, Mark D. Lessard, Edward Courchaine, Andrew E.S. Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D. Simon, Karla M. Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Mol Cell
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9732eb1548edc00558760338c886ade
https://europepmc.org/articles/PMC8988922/
https://europepmc.org/articles/PMC8988922/
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Autor:
Shilpita Karmakar, Kiran V. Paul, Botti, Ross Rj, Oscar Ramirez, Mozos IRdl, Manoj M. Pillai, Abhishek K. Gupta, Nils Neuenkirchen, Karla M. Neugebauer
Musashi 2 (MSI2) is an RNA binding protein (RBP) that regulates asymmetric cell division and cell fate decisions in normal and cancer stem cells. MSI2 appears to repress translation by binding to 3’ untranslated regions (3’UTRs) of mRNA, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a998a934d51078f26dcd4e08fe718683
https://doi.org/10.1101/2021.02.06.428911
https://doi.org/10.1101/2021.02.06.428911
Publikováno v:
G3: Genes|Genomes|Genetics
Small noncoding RNA pathways have been implicated in diverse mechanisms of gene regulation. In Drosophila ovaries, Piwi binds to Piwi-interacting RNAs (piRNAs) of mostly 24–28 nucleotides (nt) and plays an important role in germline stem cell maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530470a75ae48be6a9cd8f119c7f8131
https://doi.org/10.1093/g3journal/jkaa059
https://doi.org/10.1093/g3journal/jkaa059
Publikováno v:
Genetics. 211:201-217
Heterochromatin protein1a (HP1a) is a highly conserved epigenetic factor that associates with heterochromatin in gene silencing. Though it can activate transcription, the function of HP1a in development has been under-investigated..... Heterochromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6cca1a7a1e87faa9fbcb20fa2d75d8
https://doi.org/10.1534/genetics.118.301704
https://doi.org/10.1534/genetics.118.301704
Autor:
Giulia Biancon, Poorval Joshi, Joshua T Zimmer, Torben Hunck, Yimeng Gao, Mark D Lessard, Edward Courchaine, Andrew ES Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D Simon, Karla M Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Blood. 138:321-321
Somatic mutations in splicing factor genes are drivers of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The splicing factors U2AF1 and U2AF2 form the U2AF heterodimer that is critical in the 3' splice site (3'SS) recognition and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555d27e6450c6e578e8e60c9b5020b9d
https://doi.org/10.1182/blood-2021-149618
https://doi.org/10.1182/blood-2021-149618
Autor:
Torben Hunck, Giulia Biancon, Rana Gbyli, Toma Tebaldi, Anastasia Ardasheva, Nils Neuenkirchen, Xiaoying Fu, Haifan Lin, Valentina Botti, Karla M. Neugebauer, Josh Zimmer, Matthew D. Simon, Amisha Patel, Martin Machyna, Gabriella Viero, Poorval Joshi, Stephanie Halene, Yimeng Gao, Ashley Taylor, Ashley Qin
Publikováno v:
Blood. 136:3-4
Spliceosomal gene mutations function as drivers of hematologic malignancies and other cancers with an occurrence of more than 50% in myelodysplastic syndromes and secondary acute myeloid leukemia. Hotspot mutations S34F and Q157R in the two zinc fing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc70ddf09b648f11e42de46c47b39c3d
https://doi.org/10.1182/blood-2020-142854
https://doi.org/10.1182/blood-2020-142854