Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nils L. Visser"'
Autor:
Georgi Apriamashvili, David W. Vredevoogd, Oscar Krijgsman, Onno B. Bleijerveld, Maarten A. Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J. H. Traets, Daniela D’Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L. Visser, James D. Londino, Rebekah Sanchez-Hodge, Leah E. Oswalt, Selin Altinok, Jonathan C. Schisler, Maarten Altelaar, Daniel S. Peeper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquiti
Externí odkaz:
https://doaj.org/article/f0bd442465bb48f98bd8089ae3c35166
TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
Resistance to cancer immunotherapy continues to impair common clinical benefit. Here, we uncover an important role for Tuberous Sclerosis Complex 2 (TSC2) in determining tumor susceptibility to cytotoxic T lymphocytes (CTL) killing, bothin vitroandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b0c361bc56721efb3c91f9590d9e5e
https://doi.org/10.1101/2022.05.09.491124
https://doi.org/10.1101/2022.05.09.491124
Autor:
Andreas Lingnau, David W. Vredevoogd, Julia Boshuizen, Nora Pencheva, Daniela D’Empaire Altimari, Georgi Apriamashvili, Mischa Houtkamp, Nils L. Visser, Elke Gresnigt-van den Heuvel, Patrick Franken, Theo S. Plantinga, Oscar Krijgsman, Daniel S. Peeper, Beaunelle de Bruijn, Maria Jure-Kunkel, Ji-Ying Song, Patricia Garrido Castro, Maarten L. Janmaat, Maarten A. Ligtenberg
Publikováno v:
Cancer Research. 81:1775-1787
Although immune checkpoint blockade (ICB) has shown remarkable clinical benefit in a subset of patients with melanoma and lung cancer, most patients experience no durable benefit. The receptor tyrosine kinase AXL is commonly implicated in therapy res
Autor:
Daniela D’Empaire Altimari, Nils L. Visser, James D. Londino, Onno B. Bleijerveld, Oscar Krijgsman, Daniel S. Peeper, Julia Boshuizen, Beaunelle de Bruijn, Maarten Altelaar, Maarten A. Ligtenberg, David W. Vredevoogd, Georgi Apriamashvili
Despite the success of immune checkpoint blockade (ICB) most patients fail to respond durably, in part owing to reduced interferon gamma (IFNγ) sensitivity. Thus, elevating tumor IFNγ-receptor 1 (IFNγ-R1) expression to enhance IFNγ-mediated cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee443e537b190ee05d5339bdbb190472
https://doi.org/10.1101/2020.07.07.191650
https://doi.org/10.1101/2020.07.07.191650
Autor:
Sandra S. de Vries, Ludo Pagie, Nils L. Visser, Carolyn A. de Graaf, Daniel S. Peeper, Christelle Lenain, Daniel Peric-Hupkes, Marcel de Haas, Bas van Steensel
Publikováno v:
Genome research. 27(10)
Cellular senescence is a mechanism that virtually irreversibly suppresses the proliferative capacity of cells in response to various stress signals. This includes the expression of activated oncogenes, which causes Oncogene-Induced Senescence (OIS).
Autor:
Fabien Reyal, Marjon A. Smit, Jamila Laoukili, Sedef Iskit, Thomas R. Geiger, Alexandre Prieur, Ben S. Wittner, Bastiaan Evers, Boris Rodenko, Wilbert Zwart, Tristan Gallenne, Martin H. van Vliet, Hugo M. Horlings, Christophe Desmet, Lodewyk F. A. Wessels, Daniel S. Peeper, Abderrahrim Ajouaou, Nils L. Visser, John Zevenhoven, Sridhar Ramaswamy
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5139-5144
Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are key signal integrators connecting cellular processes to clinical outcome, we aimed to identif
Autor:
Nils L. Visser, Johannes A. M. te Poele, Jack P.M. Cleutjens, Saske Hoving, Marion J.J. Gijbels, Fiona A. Stewart, Mat J.A.P. Daemen, Sylvia Heeneman, Nicola S. Russell
Publikováno v:
Radiotherapy and oncology, 105(3), 365-370. Elsevier Ireland Ltd
Radiotherapy and Oncology, 105, 3, pp. 365-70
Radiotherapy and Oncology, 105(3), 365-370. Elsevier Ireland Ltd
Radiotherapy and Oncology, 105, 365-70
Radiotherapy and Oncology, 105, 3, pp. 365-70
Radiotherapy and Oncology, 105(3), 365-370. Elsevier Ireland Ltd
Radiotherapy and Oncology, 105, 365-70
Background and purpose: We have previously shown that irradiation to the carotid arteries of hypercholesterolemic ApoE(-/-) mice accelerated the development of macrophage-rich, inflammatory atherosclerotic lesions. We now investigated the mechanism u
Autor:
Mat J.A.P. Daemen, Ingar Seemann, Nils L. Visser, Karen Gabriels, Fiona A. Stewart, Jeffrey F. Pol, Marion J.J. Gijbels, Saske Hoving, Sylvia Heeneman
Publikováno v:
Radiotherapy and Oncology, 105(3), 358-364. Elsevier Ireland Ltd
Radiotherapy and oncology, 105(3), 358-364. Elsevier Ireland Ltd
Radiotherapy and oncology, 105(3), 358-364. Elsevier Ireland Ltd
Background and purpose Radiotherapy of thoracic and chest-wall tumors increases the long-term risk of radiation-induced heart disease, like a myocardial infarct. Cancer patients commonly have additional risk factors for cardiovascular disease, such a
Publikováno v:
International journal of radiation biology. 89(9)
Radiotherapy to the thorax increases the risk of radiation-induced heart disease. We and others have shown that local irradiation to the murine heart results in inflammatory and fibrotic responses and decreased microvascular density. In the present s