The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Autor: Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to

Externí odkaz: https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca

Somatostatin secretion by Na

Autor: Elisa, Vergari, Geoffrey, Denwood, Albert, Salehi, Quan, Zhang, Julie, Adam, Ahmed, Alrifaiy, Ingrid, Wernstedt Asterholm, Anna, Benrick, Margarita V, Chibalina, Lena, Eliasson, Claudia, Guida, Thomas G, Hill, Alexander, Hamilton, Reshma, Ramracheya, Frank, Reimann, Nils J G, Rorsman, Ioannis, Spilliotis, Andrei I, Tarasov, Jonathan N, Walker, Patrik, Rorsman, Linford J B, Briant

Publikováno v: Nature metabolism

Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells1. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8728aed0ffed1d0143859c00a12ace8
https://pubmed.ncbi.nlm.nih.gov/31993555

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Autor: Julie, Adam, Reshma, Ramracheya, Margarita V, Chibalina, Nicola, Ternette, Alexander, Hamilton, Andrei I, Tarasov, Quan, Zhang, Eduardo, Rebelato, Nils J G, Rorsman, Rafael, Martín-Del-Río, Amy, Lewis, Gizem, Özkan, Hyun Woong, Do, Peter, Spégel, Kaori, Saitoh, Keiko, Kato, Kaori, Igarashi, Benedikt M, Kessler, Christopher W, Pugh, Jorge, Tamarit-Rodriguez, Hindrik, Mulder, Anne, Clark, Norma, Frizzell, Tomoyoshi, Soga, Frances M, Ashcroft, Andrew, Silver, Patrick J, Pollard, Patrik, Rorsman

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cell Reports, Vol 20, Iss 13, Pp 3135-3148 (2017)
Cell Reports

Summary We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::48d3b9987dee790820050727259da981
https://hdl.handle.net/20.500.12530/30286

Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker.

Autor: Ta, Chau M¹, Adomaviciene, Aiste^1,2, Rorsman, Nils J G^1,3, Garnett, Hannah¹, Tammaro, Paolo^1,3

Publikováno v: British Journal of Pharmacology. Feb2016, Vol. 173 Issue 3, p511-528. 18p.

Na⁺ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Autor: Zhang, Quan, Chibalina, Margarita V., Bengtsson, Martin, Groschner, Lukas N., Ramracheya, Reshma, Rorsman, Nils J. G., Leiss, Veronika, Nassar, Mohammed A., Welling, Andrea, Gribble, Fiona M., Reimann, Frank, Hofmann, Franz, Wood, John N., Ashcroft, Frances M., Rorsman, Patrik

Publikováno v: Journal of Physiology; 11/1/2014, Vol. 592 Issue 21, p4677-4696, 20p