Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Nils Hartmann"'
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Deleterious mutations in the BRCA1 and BRCA2 genes have significant therapeutic relevance in clinical settings regarding personalized therapy approaches. BRCA1 and BRCA2 play a pivotal role in homologous recombination (HR) and thus are sensi
Externí odkaz:
https://doaj.org/article/9b46acf41d8c4a2486842ace7658b395
Autor:
Anna Haupts, Anne Vogel, Sebastian Foersch, Monika Hartmann, Annett Maderer, Nicolas Wachter, Tobias Huber, Werner Kneist, Wilfried Roth, Hauke Lang, Markus Moehler, Nils Hartmann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The current standard for molecular profiling of colorectal cancer (CRC) is using resected or biopsied tissue specimens. However, they are limited regarding sampling frequency, representation of tumor heterogeneity, and sampling can expose pa
Externí odkaz:
https://doaj.org/article/a0ed0fa91b424f0dac5d064546a90fbe
Autor:
Monserrat Gerardo-Ramírez, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Helen Morrison, Helen L. May-Simera, Markus P. Radsak, Jens U. Marquardt, Peter R. Galle, Peter Herrlich, Beate K. Straub, Monika Hartmann
Publikováno v:
Cells, Vol 12, Iss 9, p 1257 (2023)
Primary liver cancer is the third leading cause of cancer-related death worldwide. An increasing body of evidence suggests that the Hippo tumor suppressor pathway plays a critical role in restricting cell proliferation and determining cell fate durin
Externí odkaz:
https://doaj.org/article/3004799beb8e45d18efc30d9e611b166
Autor:
Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth, Beate Katharina Straub
Publikováno v:
Cells, Vol 12, Iss 1, p 73 (2022)
The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis
Externí odkaz:
https://doaj.org/article/f287bb2fd5bb400fbd684443b0ca8a2a
Autor:
Monserrat Gerardo-Ramírez, Friederike L. Keggenhoff, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Beate K. Straub, Helen Morrison, Peter R. Galle, Jens U. Marquardt, Peter Herrlich, Monika Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8616 (2022)
Osteosarcoma is the most common type of pediatric bone tumor. Despite great advances in chemotherapy during the past decades, the survival rates of osteosarcoma patients remain unsatisfactory. Drug resistance is one of the main reasons, leading to tr
Externí odkaz:
https://doaj.org/article/8c515b993e744499968f10388ad7a863
Autor:
Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner, Sabine Merkelbach-Bruse
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-6 (2019)
Abstract Background Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized treatment options in
Externí odkaz:
https://doaj.org/article/6877420e7dd24c4ca9eb6d41ff1a1165
Autor:
Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Jule Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W. Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degener
Externí odkaz:
https://doaj.org/article/463f3bfceed14b74b71020ee1edcf215
Publikováno v:
Endocrine Connections, Vol 7, Iss 1, Pp 47-55 (2017)
Poorly differentiated thyroid carcinoma (PDTC) is a rare malignancy with higher mortality than well-differentiated thyroid carcinoma. The histological diagnosis can be difficult as well as the therapy. Improved diagnosis and new targeted therapies re
Externí odkaz:
https://doaj.org/article/8899b1ae495d4406ab81b76df394dc5f
Autor:
Simon Lam, Nils Hartmann, Rui Benfeitas, Cheng Zhang, Muhammad Arif, Hasan Turkez, Mathias Uhlén, Christoph Englert, Robert Knight, Adil Mardinoglu
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1310 (2021)
Neurodegenerative diseases, including Alzheimer’s (AD) and Parkinson’s diseases (PD), are complex heterogeneous diseases with highly variable patient responses to treatment. Due to the growing evidence for ageing-related clinical and pathological
Externí odkaz:
https://doaj.org/article/c56df0c65d2c484ea45f884de8c208b2
Autor:
Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Jule Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W. Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained an error in the spelling of the author Jule Müller, which was incorrectly given as Julia Müller. Additionally, in Fig. 4a, the blue-red colour scale for fold change in ageing/disease regulation include
Externí odkaz:
https://doaj.org/article/de3a5a1d161d427aa7fec4ef7bbcb4ed