An Aeroplysinin-1 Specific Nitrile Hydratase Isolated from the Marine Sponge Aplysina cavernicola

Autor: Peter Proksch, Lutz Schmitt, Bartosz Lipowicz, Nils Hanekop

Publikováno v: Marine Drugs, Vol 11, Iss 8, Pp 3046-3067 (2013)

A nitrile hydratase (NHase) that specifically accepts the nitrile aeroplysinin-1 (1) as a substrate and converts it into the dienone amide verongiaquinol (7) was isolated, partially purified and characterized from the Mediterranean sponge Aplysina ca

Externí odkaz: https://doaj.org/article/2cafdce90f5c43139464130de8f6b2a4

Generating Symmetry in the Asymmetric ATP-binding Cassette (ABC) Transporter Pdr5 from Saccharomyces cerevisiae

Autor: Nils Hanekop, Lutz Schmitt, Petra Kueppers, Rakeshkumar P. Gupta

Publikováno v: Journal of Biological Chemistry. 289:15272-15279

Pdr5 is a plasma membrane-bound ABC transporter from Saccharomyces cerevisiae and is involved in the phenomenon of resistance against xenobiotics, which are clinically relevant in bacteria, fungi, and humans. Many fungal ABC transporters such as Pdr5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a974fe6c1928ca895e7c650bad809
https://doi.org/10.1074/jbc.m114.553065

Analysis of the inhibition potential of zosuquidar derivatives on selected bacterial and fungal ABC transporters

Autor: Nacera Infed, Lutz Schmitt, Torsten Dittrich, Nils Hanekop, Arnold J. M. Driessen, Manfred Braun, Sander H. J. Smits

Publikováno v: Molecular Membrane Biology, 30(2), 217-227

The increasing number of multidrug-resistant pathogenic microorganisms is a serious public health issue. Among the multitude of mechanisms that lead to multidrug resistance, the active extrusion of toxic compounds, mediated by MDR efflux pumps, plays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342d85fc12f1b8333cae86fa9a7c16f8
https://research.rug.nl/en/publications/94711447-c355-4ce9-8516-8478bfc1c51f

Crystal structure of the ligand-binding protein EhuB from Sinorhizobium meliloti reveals substrate recognition of the compatible solutes ectoine and hydroxyectoine

Autor: Linda Sohn-Bösser, Erhard Bremer, Marina Höing, Nils Hanekop, Mohamed Jebbar, Lutz Schmitt

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, 2007, 374 (5), pp.1237-50. ⟨10.1016/j.jmb.2007.09.071⟩
Journal of Molecular Biology, Elsevier, 2007, 374 (5), pp.1237-50. ⟨10.1016/j.jmb.2007.09.071⟩

International audience; In microorganisms, members of the binding-protein-dependent ATP-binding cassette transporter superfamily constitute an important class of transport systems. Some of them are involved in osmoprotection under hyperosmotic stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb4834045257f7cd6b33fc8f0e0e0dc
https://hal.science/hal-00193506

A Receptor for Glycolipid Headgroups Mediates Insulin-mimetic Signaling in Rat Adipocytes

Autor: Stefan Petry, Nils Hanekop, Norbert Tennagels, Susanne Wied, Wendelin Frick, G nter M ller

Publikováno v: GBM Annual Fall meeting Halle 2002. 2002

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa910826f28f065a02a7aaf75f0af366
https://doi.org/10.1240/sav_gbm_2002_h_000012