Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Nils G Walter"'
A nascent riboswitch helix orchestrates robust transcriptional regulation through signal integration
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Widespread manganese-sensing transcriptional riboswitches effect the dependable gene regulation needed for bacterial manganese homeostasis in changing environments. Riboswitches – like most structured RNAs – are believed to fold co-trans
Externí odkaz:
https://doaj.org/article/192d7aa34a3749128124d8df373bc39b
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20359 (2011)
RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (s
Externí odkaz:
https://doaj.org/article/4e9710e45fa343e28617900bf709df1b
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12953 (2010)
Due to the energetic frustration of RNA folding, tertiary structured RNA is typically characterized by a rugged folding free energy landscape where deep kinetic barriers separate numerous misfolded states from one or more native states. While most in
Externí odkaz:
https://doaj.org/article/6897c423cc4c4701af09e6fa5142cd31
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
A single molecule fluorescence study revealed three dynamically interconverting conformations of the fluoride riboswitch from Bacillus cereus, where an anionic ligand snap-locks a docked conformation through a long-range interaction necessary for dow
Externí odkaz:
https://doaj.org/article/6b22dab2d431435caa34baf4000945a7
Publikováno v:
Cells, Vol 12, Iss 18, p 2250 (2023)
Cellular biomolecular condensates, termed ribonucleoprotein (RNP) granules, are often enriched in messenger RNA (mRNA) molecules relative to the surrounding cytoplasm. Yet, the spatial localization and diffusion of mRNAs in close proximity to phase s
Externí odkaz:
https://doaj.org/article/93cf3e3f097a4608a6bbd126fc1854ca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications
Externí odkaz:
https://doaj.org/article/e41c9c9671084acbbaf16ef58f178d60
Autor:
Krishna C. Suddala, Ian R. Price, Shiba S. Dandpat, Michal Janeček, Petra Kührová, Jiří Šponer, Pavel Banáš, Ailong Ke, Nils G. Walter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Riboswitches bind intracellular metabolites and control bacterial gene expression. Here, by using X-ray crystallography, molecular dynamics simulations, and single-molecule fluorescence resonance energy transfer, the authors show how a local Mn2+ ion
Externí odkaz:
https://doaj.org/article/a105e074773f48059aba90c0f77a1c51
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′ untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures upon binding to cognate ligands. Alteration of the riboswitch's secondary
Externí odkaz:
https://doaj.org/article/59ba54e728554486be11dba23521db04
Autor:
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz, Nils G. Walter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution conf
Externí odkaz:
https://doaj.org/article/311b4e87aa5d46d280d8e1c2f066cf5b
Publikováno v:
Nucleic Acids Research. 50:8818-8833
Noncoding, structured 5′-untranslated regions (5′-UTRs) of bacterial messenger RNAs (mRNAs) can control translation efficiency by forming structures that either recruit or repel the ribosome. Here we exploit a 5′-UTR embedded preQ1-sensing, pse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42f29ff5097e216ab6cb1f3b842bd44
https://doi.org/10.1093/nar/gkac635
https://doi.org/10.1093/nar/gkac635