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pro vyhledávání: '"Nils Erik Huseby"'
Autor:
Nils-Erik Huseby
Publikováno v:
Glutamine and Glutamate in Mammals ISBN: 9781351072298
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baf9bb0a1b02ea4fbb45e398f72f97ac
https://doi.org/10.1201/9781351072298-10
https://doi.org/10.1201/9781351072298-10
Publikováno v:
Free Radical Research. 47:394-403
The enzymes γ-glutamyltransferase (GGT) and glutamate cysteine ligase (GCL) have important roles in glutathione (GSH) homeostasis, and both are frequently upregulated after acute oxidative stress. Mitochondria are major producers of ROS, and incubat
The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function
Autor:
Chandra Sekhar Ravuri, Jan-Olof Winberg, Oddveig G Rikardsen, Nils-Erik Huseby, Gunbjørg Svineng
Publikováno v:
Connective Tissue Research. 49:197-202
Cell adhesion and migration is largely dependent on integrin binding to extracellular matrix, and several signalling pathways involved in these processes have been shown to be modified by reactive oxygen species (ROS). In fact, integrin activation is
Publikováno v:
Free Radical Research. 41:1376-1384
Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characte
Publikováno v:
Free radical research. 50(1)
Proteasome inhibitors may induce ER stress and oxidative stress, disrupt signaling pathways, and trigger apoptosis in several cancer cells. However, they are also reported to increase glutathione (GSH) synthesis and protect cells from oxidative stres
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1760:151-157
The activity of gamma-glutamyltransferase (GGT) is frequently upregulated in tumor cells after oxidative stress and may thus increase the availability of amino acids needed for biosynthesis of the antioxidant glutathione. As gamma-radiation of tumor
Publikováno v:
Clinical & Experimental Metastasis. 21:331-338
Injection of the rat colon carcinoma cell line CC531 into spleen of syngeneic rats results in considerable amounts of liver metastases within 14 days. We investigated whether preincubation of the cells with butyrate reduced their metastatic ability i
Autor:
Øystein Mathisen, Kristin Bjørnland, Athanase Visvikis, Maria Wellman, Jeanette Hammer Andersen, Roy M. Bremnes, Nils-Erik Huseby, Ingvild Pettersen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1648:210-218
The enzyme gamma-glutamyltransferase (GGT) is frequently overexpressed in cancer cells and tissues and has significant utility as a cancer marker. Significant heterogeneity of the enzyme has been described due to both transcriptional and post-transla
Autor:
Nils-Erik Huseby, Maria Wellman, Idun Merete Mikkelsen, N. Asare, S. Wetting, Bente Mortensen
Publikováno v:
BioFactors. 17:151-160
Glutathione (GSH) is an important and abundant antioxidant in most cells, including cancer cells. The GSH level can be significantly reduced during oxidative and nitrosative stress, and GSH depletion is an early step in apoptosis. As most cells have
Publikováno v:
Biochemical Pharmacology. 64:307-315
The single-copy gene for rat γ-glutamyltransferase (GGT) encodes at least seven distinct mRNAs that differ in their 5′-untranslated regions only. Tissue- and developmental-specific expression of GGT is partly achieved by the presence of many trans