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Ustekinumab Is Rapid-Acting and Is an Effective Long-Term Treatment for Patients with Active Psoriatic Arthritis: Real-World Evidence from the Non-interventional SUSTAIN Study

Autor: Jörg Wendler, Nils Damann, Marit Röcken, Verena Teicher, Maximilian Schuier, Frank Hamann, Holger Schwenke, Maren Sieburg, Frank Behrens

Publikováno v: Rheumatology and Therapy. 9:1435-1450

Psoriatic arthritis (PsA) is a chronic, progressive disease that places a significant burden on patients and healthcare systems. The SUSTAIN study collected real-world evidence on long-term effectiveness, impact on quality of life, and safety of uste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8e773795bbd0161b86742bccb2b295
https://doi.org/10.1007/s40744-022-00484-3

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In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523

Autor: Jeewoo Lee, Bernhard Lesch, Nils Damann, Gregor Bahrenberg, Thomas Christoph, Robert Frank-Foltyn, Christopher Habermann, Jihyae Ann, Hannelore Stockhausen

Publikováno v: European journal of pharmacology. 871

The TRPV1 ion channel is a neuronal sensor that plays an important role in nociception and neuropathic as well as inflammatory pain. In clinical trials, hyperthermia and thermo-hypoaesthesia turned out as major side effects of TRPV1 antagonists, prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46190cb2734a043d77d3de0a9c376d70
https://pubmed.ncbi.nlm.nih.gov/31954706

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AB0786 HIGH TREATMENT SATISFACTION OF THERAPY WITH USTEKINUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS DUE TO EARLY AND LONG-TERM TREATMENT RESPONSE AND HIGH TOLERABILITY – RESULTS OF THE NON-INTERVENTIONAL STUDY SUSTAIN

Autor: Peter Wagener, Frank Behrens, Joerg Wendler, Frank Hamann, Nils Damann, Evgenia Movshovich

Publikováno v: Abstracts accepted for Publication.

Background: SUSTAIN is a prospective, multi-center non-interventional study in Germany. Objectives: The objectives are to observe long term efficacy and safety, quality of life and further patient reported outcomes in patients with active psoriatic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96768cc9197bb9177ccab65bb986fdbf
https://doi.org/10.1136/annrheumdis-2019-eular.4655

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Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

Autor: Nils Damann, Torsten Hertrampf, Antonio Nardi, Achim Kless

Publikováno v: ChemMedChem. 7:1712-1740

Blockade of voltage-gated sodium channels (VGSCs) has been used successfully in the clinic to enable control of pathological firing patterns that occur in conditions as diverse as chronic pain, epilepsy, and arrhythmias. Herein we review the state of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e06e0e59d938d72c2845056d169fe45
https://doi.org/10.1002/cmdc.201200298

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Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): A 'live-cell'-tracing tool for analysis of identified neurons in vitro

Autor: Hanns Hatt, Christian H. Wetzel, Barbara G. Klupp, Thomas C. Mettenleiter, Markus Rothermel, Nils Damann, Nicole Schöbel

Publikováno v: Journal of Neurovirology. 13:579-585

The Pseudorabies virus (PrV) strain Bartha is widely used as a tool for retrograde transneuronal tracing in mammals. Traced neurons can be identified in cell culture allowing the analysis of their physiological features ("live-cell"-tracing). Compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf8c5e625a5cecebf389aef8bf78bd
https://doi.org/10.1080/13550280701586419

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Neuronal pathways of viral invasion in mice after intranasal inoculation of pseudorabies virus PrV-9112C2 expressing bovine herpesvirus 1 glycoprotein B

Autor: Christian H. Wetzel, Markus Rothermel, Robert Klopfleisch, Hanns Hatt, Julia F. Doerner, Thomas C. Mettenleiter, Nils Damann

Publikováno v: Journal of Neurovirology. 12:60-64

In contrast to wild-type Pseudorabies virus (PrV), which infects the central nervous system mainly via fibres of the trigeminal and autonomous nerves, the PrV mutant PrV-9112C2, deleted in glycoprotein B but expressing its bovine herpesvirus 1 (BHV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd1a6e2f40a33e81f81e93d866ff57b
https://doi.org/10.1080/13550280500516450

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ChemInform Abstract: Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

Autor: Antonio Nardi, Torsten Hertrampf, Nils Damann, Achim Kless

Publikováno v: ChemInform. 43

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9b95507243c9877a6ac97de0295e83f
https://doi.org/10.1002/chin.201252195

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Direct activation of transient receptor potential V1 by nickel ions

Autor: Matthias Luebbert, Christian H. Wetzel, Debbie Radtke, Hanns Hatt, Nils Damann, Rachel Wodarski

Publikováno v: Pflugers Archiv : European journal of physiology. 459(5)

TRPV1 is a member of the transient receptor potential (TRP) family of cation channels. It is expressed in sensory neurons of the dorsal root and trigeminal ganglia as well as in a wide range of non-neuronal tissues. The channel proteins serve as poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1d5eb590c57b1422e24f4b8958b3c1
https://pubmed.ncbi.nlm.nih.gov/20101408

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