Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Nils J. Færgeman"'
Autor:
Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Havelund, Arnaud Stigliani, Nils J. Færgeman, Audrey Prézelin, Julie Rivière, Anne Couturier-Tarrade, Vyacheslav Akimov, Blagoy Blagoev, Betina Elfving, Ditte Neess, Ulla Vogel, Konstantin Khodosevich, Karin Sørig Hougaard, Albin Sandelin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lu
Externí odkaz:
https://doaj.org/article/f27ea51dbf684c569e6842c66b46c497
Autor:
Ulrika Simone Spangsberg Petersen, Maja Dembic, Ainhoa Martínez-Pizarro, Eva Richard, Lise Lolle Holm, Jesper Foged Havelund, Thomas Koed Doktor, Martin Røssel Larsen, Nils J. Færgeman, Lourdes Ruiz Desviat, Brage Storstein Andresen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102101- (2024)
Pseudoexons are nonfunctional intronic sequences that can be activated by deep-intronic sequence variation. Activation increases pseudoexon inclusion in mRNA and interferes with normal gene expression. The PCCA c.1285-1416A>G variation activates a ps
Externí odkaz:
https://doaj.org/article/ff8b723093454117929845437197aef9
Autor:
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman, Anne Spang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone recep
Externí odkaz:
https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d73484
Autor:
Jonas Ellegaard Nielsen, Raluca Georgiana Maltesen, Jesper F. Havelund, Nils J. Færgeman, Charlotte Held Gotfredsen, Karsten Vestergård, Søren Risom Kristensen, Shona Pedersen
Publikováno v:
Metabolism Open, Vol 12, Iss , Pp 100125- (2021)
Background: Alzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein regulations and might reflect
Externí odkaz:
https://doaj.org/article/ecfb0607ea694f328606f3b4d43b10a6
Autor:
Stine M. Præstholm, Catarina M. Correia, Victor E. Goitea, Majken S. Siersbæk, Mathilde Jørgensen, Jesper F. Havelund, Thomas Å. Pedersen, Nils J. Færgeman, Lars Grøntved
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109938- (2021)
Summary: The transition from a fasted to a fed state is associated with extensive transcriptional remodeling in hepatocytes facilitated by hormonal- and nutritional-regulated transcription factors. Here, we use a liver-specific glucocorticoid recepto
Externí odkaz:
https://doaj.org/article/830a919b1e394d2a9c82955554f4eaec
Autor:
Ditte Neess, Vibeke Kruse, Ann-Britt Marcher, Mie Rye Wæde, Julie Vistisen, Pauline M. Møller, Rikke Petersen, Jonathan R. Brewer, Tao Ma, Georgia Colleluori, Ilenia Severi, Saverio Cinti, Zach Gerhart-Hines, Susanne Mandrup, Nils J. Færgeman
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101144- (2021)
Objectives: The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological respo
Externí odkaz:
https://doaj.org/article/1804191abfef4a3bb04c6cbbccd5ca3f
Autor:
Muriel G M D Almeida, Daniela S Arêdes, David Majerowicz, Nils J Færgeman, Jens Knudsen, Katia C Gondim
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227685 (2020)
The acyl-CoA-binding proteins (ACBP) act by regulating the availability of acyl-CoA in the cytoplasm and must have essential functions in lipid metabolism. The genome of the kissing-bug Rhodnius prolixus encodes five proteins of this family, but litt
Externí odkaz:
https://doaj.org/article/d94e954ad6594513b2fa7dc75b2b409c
Autor:
Lea B. S. Hansen, Henrik M. Roager, Nadja B. Søndertoft, Rikke J. Gøbel, Mette Kristensen, Mireia Vallès-Colomer, Sara Vieira-Silva, Sabine Ibrügger, Mads V. Lind, Rasmus B. Mærkedahl, Martin I. Bahl, Mia L. Madsen, Jesper Havelund, Gwen Falony, Inge Tetens, Trine Nielsen, Kristine H. Allin, Henrik L. Frandsen, Bolette Hartmann, Jens Juul Holst, Morten H. Sparholt, Jesper Holck, Andreas Blennow, Janne Marie Moll, Anne S. Meyer, Camilla Hoppe, Jørgen H. Poulsen, Vera Carvalho, Domenico Sagnelli, Marlene D. Dalgaard, Anders F. Christensen, Magnus Christian Lydolph, Alastair B. Ross, Silas Villas-Bôas, Susanne Brix, Thomas Sicheritz-Pontén, Karsten Buschard, Allan Linneberg, Jüri J. Rumessen, Claus T. Ekstrøm, Christian Ritz, Karsten Kristiansen, H. Bjørn Nielsen, Henrik Vestergaard, Nils J. Færgeman, Jeroen Raes, Hanne Frøkiær, Torben Hansen, Lotte Lauritzen, Ramneek Gupta, Tine Rask Licht, Oluf Pedersen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Gluten-free diets are increasingly common in the general population. Here, the authors report the results of a randomised cross-over trial involving middle-aged, healthy Danish adults, showing evidence that a low-gluten diet leads to gut microbiome c
Externí odkaz:
https://doaj.org/article/5b2e96389d364ce78ea21c54d037072f
Autor:
Janne R. Hingst, Lea Bruhn, Mads B. Hansen, Marie F. Rosschou, Jesper B. Birk, Joachim Fentz, Marc Foretz, Benoit Viollet, Kei Sakamoto, Nils J. Færgeman, Jesper F. Havelund, Benjamin L. Parker, David E. James, Bente Kiens, Erik A. Richter, Jørgen Jensen, Jørgen F.P. Wojtaszewski
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 24-34 (2018)
Objective: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. Methods
Externí odkaz:
https://doaj.org/article/a0f13e6c4f264a02a10483039f72c400
Autor:
Julia Bandres-Meriz, Christina Kunz, Jesper F. Havelund, Nils J. Færgeman, Alejandro Majali-Martinez, Regina Ensenauer, Gernot Desoye
Publikováno v:
International Journal of Obesity.
Background/Objectives Obesity in pregnancy associates with changes in the glucose-insulin axis. We hypothesized that these changes affect the maternal metabolome already in the first trimester of human pregnancy and, thus, aimed to identify these met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07935a3263ebec819cf506e4031637d8
https://doi.org/10.1038/s41366-023-01295-4
https://doi.org/10.1038/s41366-023-01295-4