Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Nils, Wierup"'
Autor:
Andreas Lindqvist, Mia Abels, Liliya Shcherbina, Mtakai Ngara, Dmytro Kryvokhyzha, Sabrina Chriett, Matteo Riva, Abul Fajul, Mohammad Barghouth, Cheng Luan, Lena Eliasson, Olav Larsen, Mette M. Rosenkilde, Enming Zhang, Erik Renström, Nils Wierup
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108416- (2023)
Summary: Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreat
Externí odkaz:
https://doaj.org/article/5b28e5d6ce9a49798e8b5a806ad188f3
Autor:
Karin G. Stenkula, Lisa Esbjörnsson Klemendz, Claes Fryklund, Nils Wierup, Wathik Alsalim, Mona Landin-Olsson, Lena Trinh, Sven Månsson, Louise Bennet
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Purpose Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with di
Externí odkaz:
https://doaj.org/article/6f0a8f9467a24ccc90c4683240276842
Autor:
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz:
https://doaj.org/article/1b6d5184407e4059bd119a1db2f0c8ba
Autor:
Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Riitta Parkkola, Leif Groop, Pirjo Nuutila
Publikováno v:
Endocrine Connections, Vol 7, Iss 7, Pp 888-896 (2018)
Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery
Externí odkaz:
https://doaj.org/article/14d055431def46d08bc5fffc17832c77
Autor:
Stefan G. Pierzynowski, Kateryna Goncharova, Peter C. Gregory, Björn Weström, Sergiy E. Podpryatov, Sergii S. Podpriatov, Jarosław Woliński, Hlib Repich, Nils Wierup, Liudmyla Lozinska
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests
Externí odkaz:
https://doaj.org/article/b5789c371c734b84ba7460ec21e6bd41
Autor:
Lisa M. Nicholas, Bérengère Valtat, Anya Medina, Lotta Andersson, Mia Abels, Inês G. Mollet, Deepak Jain, Lena Eliasson, Nils Wierup, Malin Fex, Hindrik Mulder
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial tr
Externí odkaz:
https://doaj.org/article/7c8420984bd24f1c94b700a9d5958e76
Autor:
Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop, Pirjo Nuutila
Publikováno v:
Endocrine Connections, Vol 6, Iss 3, Pp 179-187 (2017)
Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known.
Externí odkaz:
https://doaj.org/article/f5eadc2763f9414f87aff0cc173eed4e
Autor:
Anna Edlund, Morten Gram Pedersen, Andreas Lindqvist, Nils Wierup, Malin Flodström-Tullberg, Lena Eliasson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic
Externí odkaz:
https://doaj.org/article/4e5082688ab0421091e36c36b8736363
Autor:
Teemu Saari, Jukka Koffert, Henri Honka, Saila Kauhanen, Mueez U-Din, Nils Wierup, Andreas Lindqvist, Leif Groop, Kirsi A Virtanen, Pirjo Nuutila
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:1930-1938
Context Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba37d9bfef4eff461f5a702d883f6cc
https://doi.org/10.1210/clinem/dgac191
https://doi.org/10.1210/clinem/dgac191
Autor:
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B Prasad
Publikováno v:
Life Sci. All. 5:e202201376 (2022)
Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6838e3d4003c0960d52634bc747502c5
http://hdl.handle.net/10138/347726
http://hdl.handle.net/10138/347726
