Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nils, Muthmann"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2819-2832 (2017)
Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparati
Externí odkaz:
https://doaj.org/article/5dfbdefcfc5643d8958c0a4e721c52d3
Publikováno v:
Methods. 205:73-82
Post-transcriptional modifications play an important role in several processes, including translation, splicing, and RNA degradation in eukaryotic cells. To investigate the function of specific modifications it is of high interest to develop tools fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b845d89ec13297bbff575b14ad88bb
https://doi.org/10.1016/j.ymeth.2022.06.007
https://doi.org/10.1016/j.ymeth.2022.06.007
Publikováno v:
Methods
Enzymatic modification of the 5′-cap is a versatile approach to modulate the properties of mRNAs. Transfer of methyl groups from S-adenosyl- l -methionine (AdoMet) or functional moieties from non-natural analogs by methyltransferases (MTases) allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c192cc0351d30b1ee271eef364c8ea
https://doi.org/10.1016/j.ymeth.2021.05.018
https://doi.org/10.1016/j.ymeth.2021.05.018
Publikováno v:
Angewandte Chemie. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bb8d111ffe7f6a84609ad4382b3d1d
https://doi.org/10.1002/ange.202211957
https://doi.org/10.1002/ange.202211957
Publikováno v:
Angewandte Chemie International Edition. 62
Modified nucleotides impact all aspects of eukaryotic mRNAs and contribute to regulation of gene expression at the transcriptional and translational level. At the 5' cap, adenosine as first transcribed nucleotide is often N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b000a76ad7287a8baed85f37eea608
https://doi.org/10.1002/anie.202211957
https://doi.org/10.1002/anie.202211957
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie International Edition
Eukaryotic mRNAs are emerging modalities for protein replacement therapy and vaccination. Their 5′ cap is important for mRNA translation and immune response and can be naturally methylated at different positions by S‐adenosyl‐l‐methionine (Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80d81df29fe941f335e995e8a71fb0c
https://pubmed.ncbi.nlm.nih.gov/33751748
https://pubmed.ncbi.nlm.nih.gov/33751748
Publikováno v:
Chemical Science. 8:7947-7953
Site-specific alkylation of complex biomolecules is critical for late-stage product diversification as well as post-synthetic labeling and manipulation of proteins and nucleic acids. Promiscuous methyltransferases in combination with analogs of S-ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a5b6ca04143418e2ad712f2c5bbc4d
https://doi.org/10.1039/c7sc03631k
https://doi.org/10.1039/c7sc03631k
Publikováno v:
Organic & Biomolecular Chemistry. 15:278-284
Messenger RNA may not be very abundant in the cell but its central role in gene expression is indisputable. In addition to being the template for translation it can be subject for a variety of regulatory mechanisms affecting gene expression, ranging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b795631929d3ae8f5f96a5ffec4900
https://doi.org/10.1039/c6ob02144a
https://doi.org/10.1039/c6ob02144a
Autor:
Andrea Rentmeister, Jean-Jacques Vasseur, Françoise Debart, Samie R. Jaffrey, Théo Guez, Nils Muthmann
Publikováno v:
Chembiochem
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2019, ⟨10.1002/cbic.201900037⟩
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2019, ⟨10.1002/cbic.201900037⟩
International audience; Eukaryotic RNAs are heavily processed, including co- and post-transcriptional formation of various 5' caps. In small nuclear RNAs (snRNAs) or small nucleolar RNAs (snoRNAs), the canonical 7m G cap is hypermethylated at the N2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27c113c30aea01d05486442a89ad65c
https://europepmc.org/articles/PMC6755138/
https://europepmc.org/articles/PMC6755138/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2008
Photo-cross-linking moieties have proven invaluable for elucidating interactions of biomolecules. While methods for site-specific incorporation of those moieties into proteins have been developed, comparable methods for nucleic acids are lacking. Uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4a1682be3d97c70d156a95254c70779
https://pubmed.ncbi.nlm.nih.gov/31124094
https://pubmed.ncbi.nlm.nih.gov/31124094