Pathological and genetic markers improve recurrence prognostication with the University of California Los Angeles Integrated Staging System for patients with clear cell renal cell carcinoma

Autor: Nils Kroeger, Cédric Lebacle, Justine Hein, P.N. Rao, Reza Nejati, Shuanzeng Wei, Martin Burchardt, Alexandra Drakaki, Marshall Strother, Alexander Kutikov, Robert Uzzo, Allan J. Pantuck

Publikováno v: European Journal of Cancer. 168:68-76

To elucidate which patients with clear cell renal cell carcinoma have the highest risk for disease relapse after curative nephrectomy is challenging but is acutely relevant in the era of approved adjuvant therapies. Pathological and genetic markers w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f07c9d8e23fb4c7c2c50a37ffd77ae
https://doi.org/10.1016/j.ejca.2022.03.023

Thioredoxin 1 (Trx1) is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC): an example for the crucial role of redox signaling in ccRCC

Autor: Marcus Scharpf, Jens Bedke, Silvia Ribback, Manuela Gellert, Nils Kroeger, Stefan Winter, Elke Schaeffeler, Matthias Schwab, Viktoria Stühler, Christopher Horst Lillig, Tobias Klatte, Martin Burchardt

Publikováno v: World journal of urology. 40(3)

Purpose Thioredoxins are major regulatory proteins of oxidative signaling. Trx1 is the most prominent thioredoxin and, therefore, the current study sought to evaluate the prognostic role of Trx1 in ccRCC. Methods and patients A tissue micro-array (TM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bd53eafeed9e434d441c36d259c89c
https://pubmed.ncbi.nlm.nih.gov/34859284

Evaluation of the prognostic role of co-morbidities on disease outcome in renal cell carcinoma patients

Autor: Allan J. Pantuck, Frank Dombrowski, Shahrokh F. Shariat, Martin Burchardt, Arie S. Belldegrun, Tobias Klatte, Nils Kroeger, Silvia Ribback, Alexandra Drakaki, Johannes Heide

Publikováno v: World Journal of Urology. 38:1525-1533

Co-morbidities may induce local and systemic tumor progression of renal cell carcinoma (RCC); however, the prognostic impact of co-morbidities has not yet been well characterized. RCC patients (n = 2206) surgically treated at three academic instituti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e6d3d79144e5a36e60aa14a359c033
https://doi.org/10.1007/s00345-019-02930-4

Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association with Survival

Autor: Camillo Porta, M. Neil Reaume, Daniel Y.C. Heng, Shaan Dudani, Sumanta K. Pal, J. Connor Wells, Jae-Lyun Lee, Georg A. Bjarnason, Felice Pasini, Ravindran Kanesvaran, Christina Canil, Aaron R. Hansen, Frede Donskov, Takeshi Yuasa, Guillermo Velasco, Anna Paola Fraccon, Benoit Beuselinck, Nils Kroeger, Chun Loo Gan, Toni K. Choueiri

Publikováno v: Dudani, S, De Velasco, G, Wells, J C, Gan, C L, Donskov, F, Porta, C, Fraccon, A, Pasini, F, Lee, J L, Hansen, A, Bjarnason, G A, Beuselinck, B, Pal, S K, Yuasa, T, Kroeger, N, Kanesvaran, R, Reaume, M N, Canil, C, Choueiri, T K & Heng, D Y C 2021, ' Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association with Survival ', JAMA network open, vol. 4, no. 1, 21869 . https://doi.org/10.1001/jamanetworkopen.2020.21869

IMPORTANCE: There exists considerable biological and clinical variability between histologic variants of metastatic renal cell carcinoma (mRCC). Data reporting on patterns of metastasis in histologic variants of mRCC are sparse. OBJECTIVE: To charact

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https://pure.au.dk/portal/da/publications/evaluation-of-clear-cell-papillary-and-chromophobe-renal-cell-carcinoma-metastasis-sites-and-association-with-survival(71e5f952-70f6-40dc-baea-6ce7b79bed69).html

Microvascular and lymphovascular tumour invasion are associated with poor prognosis and metastatic spread in renal cell carcinoma: a validation study in clinical practice

Autor: Marcus Scharpf, Steffen Rausch, Frank Dombrowski, Shahrokh F. Shariat, Silvia Ribback, Johannes Heide, Andrea Haitel, Jens Bedke, Nils Kroeger, Martin Burchardt, Uwe Zimmermann, Arnulf Stenzl, Maik Pechoel, Hussam Alkhayyat, Tobias Klatte, Michela de Martino

Publikováno v: BJU International. 121:84-92

Objective To validate microvascular (MVI) and lymphovascular (LVI) invasion as a prognostic factor in renal cell carcinoma patients (pts.) Materials and Methods Data of patients with RCC who underwent radical or nephron sparing surgery were prospecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93eda87d80c4b57bdfa552f319290c68
https://doi.org/10.1111/bju.13984