Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nils, Kinnman"'
Autor:
Scott C. Bell, Jochen G. Mainz, Gordon MacGregor, Susan Madge, Julie Macey, Moshe Fridman, Ellison D. Suthoff, Siva Narayanan, Nils Kinnman
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Clinical studies demonstrate that ivacaftor (IVA) improves health-related quality of life (HRQoL) in patients aged ≥6 years with cystic fibrosis (CF). The real-world impact of IVA and standard of care (SOC) in groups of patients
Externí odkaz:
https://doaj.org/article/4efd007193ce4914a086b5bfedab51a4
Autor:
Dominique, Hubert, Christophe, Marguet, Jacques, Benichou, Cynthia, DeSouza, Catherine, Payen-Champenois, Nils, Kinnman, Keval, Chandarana, Anne, Munck, Isabelle, Fajac, Laurent, Mely
Publikováno v:
Pulmonary Therapy
Introduction Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has demonstrated clinical benefits in phase 3 trials. We report results from a real-world study (BRIO) to assess the effectiveness of ivacaftor in
Publikováno v:
In Hepatology 2001 34(4) Part 2:A397-A397
Autor:
Nicholas J. Simmonds, C. Kors van der Ent, Carla Colombo, Nils Kinnman, Cynthia DeSouza, Teja Thorat, Marci L. Chew, Keval Chandarana, Carlo Castellani
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
VOCAL was an observational study of the effect of long-term ivacaftor on real-world clinical outcomes and healthcare resource utilization (HCRU) in people with cystic fibrosis (pwCF) in Italy, the Netherlands, and the UK.pwCF aged ≥6 years with non
Autor:
Eitan, Kerem, Malena, Cohen-Cymberknoh, Reuven, Tsabari, Michael, Wilschanski, Joel, Reiter, David, Shoseyov, Alex, Gileles-Hillel, Thea, Pugatsch, Jane C, Davies, Christopher, Short, Clare, Saunders, Cynthia, DeSouza, James C, Sullivan, Jamie R, Doyle, Keval, Chandarana, Nils, Kinnman
Publikováno v:
Annals of the American Thoracic Society. 18(3)
Autor:
Nils Kinnman, Per Stål, Mattias Sjöström, Peter Rosenberg, Cecilia Söderberg, Rolf Hultcrantz
Publikováno v:
Liver International. 31:630-641
Aim: Neural cell adhesion molecule (N-CAM) is expressed by activated hepatic stellate cells (HSC), portal fibroblasts, cholangiocytes and hepatic progenitor cells during liver injury. Its functional role in liver disease and fibrogenesis is unknown.
Publikováno v:
Pharmacology & therapeutics. 125(3):464-475
B cell-depletion therapy, particularly using anti-CD20 treatment, has provided proof of concept that targeting B cells and the humoral response may result in clinical improvements in immune-mediated inflammatory disease. In this review, the mechanism
Autor:
Bruno Saubaméa, Peter Rosenberg, Laura Fouassier, Audrey Clapéron, Rolf Hultcrantz, Birgitta Strandvik, Nils Kinnman, Nicolas Chignard, Colette Rey, Gunilla Jacobsson-Ekman, Martine Mergey, Véronique Barbu, Chantal Housset
Publikováno v:
The American Journal of Pathology. 174:869-880
Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) anchors and regulates apical membrane proteins in epithelia. EBP50 is inducible by estrogen and may affect cell proliferation, although this latter function remains unclear. The goal of this stud
Autor:
Véronique Barbu, Colette Rey, Dominique Wendum, Claire Francoz, Nils Kinnman, Chantal Housset, Raoul Poupon, Rolf Hultcrantz
Publikováno v:
Scopus-Elsevier
The origin of myofibroblasts and the factors promoting their differentiation during liver fibrogenesis remain uncertain. During biliary-type fibrogenesis, the proliferation and chemoattraction of hepatic stellate cells (HSC) toward bile ducts is medi
Autor:
Chantal Housset, Ronald P.J. Oude Elferink, Guillaume Lefèvre, Raoul Poupon, Elisabeth Lasnier, Nils Kinnman, Colette Rey, Laura Fouassier
Publikováno v:
Journal of hepatology, 37(2), 184-191. Elsevier
Background/Aims: Bosentan, a dual endothelin ETA/B receptor antagonist, may cause dose-dependent reversible cholestatic liver injury. We herein tested whether bosentan or metabolites, both eliminated in bile, induce alterations in bile secretion. Met