Výsledky vyhledávání - "Nilofer Azad"

Akademický článek

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

Autor: Lorraine Pelosof, Sashidhar Yerram, Todd Armstrong, Nina Chu, Ludmila Danilova, Breann Yanagisawa, Manuel Hidalgo, Nilofer Azad, James G. Herman

Publikováno v: Epigenetics, Vol 12, Iss 7, Pp 540-550 (2017)

Epigenetic control of gene expression is a major determinant of tumor phenotype and has been found to influence sensitivity to individual chemotherapeutic agents. Glutathione peroxidase 3 (GPX3, plasma glutathione peroxidase) is a key component of ce

Externí odkaz: https://doaj.org/article/ef0106233e1b4f0ead57cee02a0bc36a

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Akademický článek

Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells.

Autor: Anup Sharma, Rajita Vatapalli, Eihab Abdelfatah, K Wyatt McMahon, Zachary Kerner, Angela A Guzzetta, Jasvinder Singh, Cynthia Zahnow, Stephen B Baylin, Sashidhar Yerram, Yue Hu, Nilofer Azad, Nita Ahuja

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176139 (2017)

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. In the metastatic setting, the majority of patients respond to initial therapies but eventually develop resistance and progress. In this study, we test the hypo

Externí odkaz: https://doaj.org/article/a73a5c331b244234bb5240e5e0fef558

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Akademický článek

Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits

Autor: Salma K. Jabbour, Shyamal Patel, Joseph M. Herman, Aaron Wild, Suneel N. Nagda, Taghrid Altoos, Ahmet Tunceroglu, Nilofer Azad, Susan Gearheart, Rebecca A. Moss, Elizabeth Poplin, Lydia L. Levinson, Ravi A. Chandra, Dirk F. Moore, Chunxia Chen, Bruce G. Haffty, Richard Tuli

Publikováno v: International Journal of Surgical Oncology, Vol 2012 (2012)

Purpose. To compare the acute toxicities of IMRT to 3D-conformal radiation therapy (3DCRT) in the treatment of rectal cancer. Methods and Materials. Eighty-six patients with rectal cancer preoperatively treated with IMRT (n=30) and 3DCRT (n=56) were

Externí odkaz: https://doaj.org/article/9b066ea233cd4b21807fc6aa900225d6

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Nivolumab in combination with dabrafenib and trametinib use in advanced cholangiocarcinoma with a BRAF V600E mutation and severe hepatic dysfunction: A case report and review of the literature

Autor: Chester Kao, Nilofer Azad, Rachel Klein, Kiyoko Oshima, Kayla Garzio, Aanika Balaji

Publikováno v: Journal of Case Reports and Images in Oncology. 9:1-7

Introduction: Cholangiocarcinomas (CCA) are rare, aggressive tumors often diagnosed in advanced stages with limited evidence guiding therapy on progression. Case Report: We report a case of advanced CCA with rapid and aberrant progression, refractory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::008669f17423e0b70a7b3dcff7dfb428
https://doi.org/10.5348/100117z10ab2023cr

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Data from Context-Dependent Immunomodulatory Effects of MEK Inhibition Are Enhanced with T-cell Agonist Therapy

Autor: Mark Yarchoan, Elizabeth M. Jaffee, Gregory B. Lesinski, Nilofer Azad, Skylar Woolman, Kayla Cruz, James Leatherman, Aditya Mohan, Amanda Ruggieri, Lauren Dennison

MEK inhibition (MEKi) is proposed to enhance antitumor immunity but has demonstrated mixed results as an immunomodulatory strategy in human clinical trials. MEKi exerts direct immunomodulatory effects on tumor cells and tumor-infiltrating lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d918c2fb90bbefd33af05d7a26deca
https://doi.org/10.1158/2326-6066.c.6550348

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