Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nilmani Singh"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The CRISPR-Cas12a system is more advantageous than the widely used CRISPR-Cas9 system in terms of specificity and multiplexibility. However, its on-target editing efficiency is typically much lower than that of the CRISPR-Cas9 system. Here w
Externí odkaz:
https://doaj.org/article/e003cb07ccce44dab769fcfc908294cb
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107739- (2023)
Summary: Chemically modified mRNAs hold great potential for therapeutic applications in vivo. Currently, the base modification scheme largely preserves the canonical Watson-Crick base pairing, thus missing one mode of mRNA modulation by altering its
Externí odkaz:
https://doaj.org/article/019d4e9895244cc89affbf65252a6ad2
Autor:
Behnam Enghiad, Pu Xue, Nilmani Singh, Aashutosh Girish Boob, Chengyou Shi, Vassily Andrew Petrov, Roy Liu, Siddhartha Suryanarayana Peri, Stephan Thomas Lane, Emily Danielle Gaither, Huimin Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Despite their broad utility, design and construction of plasmids remains laborious and time-consuming. Here the authors report a robust, versatile, and automated end-to-end platform that enables scarless construction of virtually any plasmid.
Externí odkaz:
https://doaj.org/article/fbc106e2485b420e9e2817ed12ef3ff3
Autor:
Nilmani Singh, Adriana Reyes-Ordoñez, Michael A. Compagnone, Jesus F. Moreno, Benjamin J. Leslie, Taekjip Ha, Jie Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific interactions are known. Using TIRF microscopy based assays, functional studies and an experimentally validated prediction algorithm, the authors show
Externí odkaz:
https://doaj.org/article/b97a6563b3fc4a5b933ad000dc6e31ec
Autor:
Jae-Sung You, Nilmani Singh, Adriana Reyes-Ordonez, Nidhi Khanna, Zehua Bao, Huimin Zhao, Jie Chen
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108731- (2021)
Externí odkaz:
https://doaj.org/article/69148122584b45e1961828c268801b99
Publikováno v:
Cell Systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80db0481701eb610f410e4c9b786fc52
https://doi.org/10.1016/j.cels.2023.04.006
https://doi.org/10.1016/j.cels.2023.04.006
Publikováno v:
Exp Cell Res
TNF-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells, although non-apoptotic functions have also been reported for this cytokine in various cell types. TRAIL and its receptor TRAIL-R2 are expressed in skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2ad37f2d139000256c9037afcaf40a
https://pubmed.ncbi.nlm.nih.gov/32645396
https://pubmed.ncbi.nlm.nih.gov/32645396
Autor:
Yu Long, Kristen F. Swaney, Jie Chen, Jane Borleis, Pablo A. Iglesias, Peter N. Devreotes, Sayak Bhattacharya, Marc Edwards, Nilmani Singh, Xiaoguang Li
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cell migration is central in physiological and pathological conditions such as immune response and cancer metastasis. The excitable network hypothesis can account for recent observations of propagating waves of signal transduction and cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dbcca8d324740946031d8a5d52ab80
http://europepmc.org/articles/PMC6166812
http://europepmc.org/articles/PMC6166812
Autor:
Nilmani Singh, Zehua Bao, Jie Chen, Nidhi Khanna, Huimin Zhao, Jae-Sung You, Adriana Reyes-Ordoñez
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108731-(2021)
SummarySkeletal muscle regeneration is essential for restoring muscle function upon injury and for the maintenance of muscle health with aging. ARHGEF3, a Rho-specific GEF, negatively regulates myoblast differentiation via mammalian target of rapamyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e6db9cd537ceaac7987b8f59104a47
https://doi.org/10.1016/j.celrep.2020.108594
https://doi.org/10.1016/j.celrep.2020.108594
Autor:
Nilmani Singh, Adriana Reyes-Ordoñez, Michael A. Compagnone, Jesus F. Moreno, Jie Chen, Lucy Yao
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0316f9f64f2b3aa4b19f8390f460e99e
https://doi.org/10.1096/fasebj.2020.34.s1.04312
https://doi.org/10.1096/fasebj.2020.34.s1.04312