Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Nilgun E Tumer"'
Autor:
John E McLaughlin, Mohamed Anwar Bin-Umer, Thomas Widiez, Daniel Finn, Susan McCormick, Nilgun E Tumer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130204 (2015)
Fusarium head blight (FHB) or scab is one of the most important plant diseases worldwide, affecting wheat, barley and other small grains. Trichothecene mycotoxins such as deoxynivalenol (DON) accumulate in the grain, presenting a food safety risk and
Externí odkaz:
https://doaj.org/article/0777416e07444936931784963c619ed8
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113719 (2014)
Ricin A chain (RTA) undergoes retrograde trafficking and is postulated to use components of the endoplasmic reticulum (ER) associated degradation (ERAD) pathway to enter the cytosol to depurinate ribosomes. However, it is not known how RTA evades deg
Externí odkaz:
https://doaj.org/article/e27ab2ca5b9c40e19e837dd45becd5c7
Autor:
Yuan-Ping Pang, Jewn Giew Park, Shaohua Wang, Anuradha Vummenthala, Rajesh K Mishra, John E McLaughlin, Rong Di, Jennifer Nielsen Kahn, Nilgun E Tumer, Laszlo Janosi, Jon Davis, Charles B Millard
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17883 (2011)
Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escheric
Externí odkaz:
https://doaj.org/article/53849408323445f0af51c1cb09d5cbd0
Autor:
Przemysław Grela, Xiao-Ping Li, Patrycja Horbowicz, Monika Dźwierzyńska, Marek Tchórzewski, Nilgun E. Tumer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The eukaryotic P-stalk contains two P1-P2 protein dimers with a conserved C- terminal domain (CTD) critical for the interaction with external factors. To understand the role of the individual CTD of human P1/P2 proteins, we examined the inte
Externí odkaz:
https://doaj.org/article/71d6133ab595498ea40a882565c22834
Autor:
Arkadiusz W. Kulczyk, Carlos Oscar S. Sorzano, Przemysław Grela, Marek Tchórzewski, Nilgun E. Tumer, Xiao-Ping Li
Publikováno v:
The Journal of biological chemistry. 299(1)
Shiga toxin 2a (Stx2a) is the virulence factor of enterohemorrhagic Escherichia coli. The catalytic A1 subunit of Stx2a (Stx2A1) interacts with the ribosomal P-stalk for loading onto the ribosome and depurination of the sarcin-ricin loop, which halts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2952714a353c67be1758b58f345b1c
https://pubmed.ncbi.nlm.nih.gov/36528064
https://pubmed.ncbi.nlm.nih.gov/36528064
Autor:
Marek Tchórzewski, Sebastian Kmiecik, Przemysław Grela, Patrycja Horbowicz-Drożdżal, Nilgun E. Tumer, Pang Chui Shaw, Karol Kamel, Lidia Borkiewicz
Publikováno v:
FEBS Letters. 595:2221-2236
The ribosome is subjected to post-translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal elements, the P-proteins undergo phosphorylation within the C terminus, the element which interacts with tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd17d34d3a698232e1ca57bf9ef9cb23
https://doi.org/10.1002/1873-3468.14170
https://doi.org/10.1002/1873-3468.14170
Autor:
Harold N. Trick, Neerja Tyagi, Nilgun E. Tumer, Noura I. Darwish, Jeffrey Garcia-Sanchez, Ruth Dill-Macky, John E. McLaughlin, Susan P. McCormick
Publikováno v:
Phytopathology®. 111:671-683
Trichothecene mycotoxins such as deoxynivalenol (DON) are virulence factors of Fusarium graminearum, which causes Fusarium head blight, one of the most important diseases of small grain cereals. We previously identified a nonspecific lipid transfer p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334a515fefb22e71191f68bf3f4dc067
https://doi.org/10.1094/phyto-04-20-0153-r
https://doi.org/10.1094/phyto-04-20-0153-r
Publikováno v:
J Biol Chem
The principal virulence factor of human pathogenic enterohemorrhagic Escherichia coli is Shiga toxin (Stx). Shiga toxin 2a (Stx2a) is the subtype most commonly associated with severe disease outcomes such as hemorrhagic colitis and hemolytic uremic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56e14738b77834f76f392f7c1adb088
https://doi.org/10.1074/jbc.ac120.015070
https://doi.org/10.1074/jbc.ac120.015070
Publikováno v:
ACS Infect Dis
Ricin toxin A subunit (RTA) removes an adenine from the universally conserved sarcin/ricin loop (SRL) on eukaryotic ribosomes, thereby inhibiting protein synthesis. No high affinity and selective small molecule therapeutic antidotes have been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af74bd57da78ed21febf877ef7c8eeaa
https://doi.org/10.1021/acsinfecdis.0c00127
https://doi.org/10.1021/acsinfecdis.0c00127
Autor:
Xiao-Ping Li, Bin Cao, Jacques Roberge, Nilgun E. Tumer, David Augeri, Anastasiia M Tsymbal, Michael Pierce, Jennifer Nielsen Kahn, Rajesh K. Harijan
Publikováno v:
Journal of medicinal chemistry. 64(20)
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against ricin. We used a new strategy to disrupt RTA-ribosome interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98582b494a2052d8b5837c327e69e18
https://pubmed.ncbi.nlm.nih.gov/34648707
https://pubmed.ncbi.nlm.nih.gov/34648707