Collagen scaffold enhances the regenerative properties of mesenchymal stromal cells.

Autor: Iran Rashedi, Nilesh Talele, Xing-Hua Wang, Boris Hinz, Milica Radisic, Armand Keating

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187348 (2017)

MSCs are widely applied to regenerate heart tissue in myocardial diseases but when grown in standard two-dimensional (2D) cultures exhibit limited potential for cardiac repair and develop fibrogenic features with increasing culture time. MSCs can und

Externí odkaz: https://doaj.org/article/4512369891fe4b19ae67e81670c622a6

The mechanical environment modulates intracellular calcium oscillation activities of myofibroblasts.

Autor: Charles Godbout, Lysianne Follonier Castella, Eric A Smith, Nilesh Talele, Melissa L Chow, Adriano Garonna, Boris Hinz

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64560 (2013)

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.

Externí odkaz: https://doaj.org/article/03c2ba9e5aa0423a9116f3fac6558e52

1463 Addition of losartan to FOLFORINOX and chemoradiation downregulates pro-invasion and immunosuppression associated genes in locally advanced pancreatic cancer

Autor: Rakesh Jain, Yves Boucher, Jessica Posada, Spencer Rosario, Liqun Gu, Ashwin Kumar, Heena Kumra, Mari Mino-Kenudson, Nilesh Talele, Dan Duda, Dai Fukumura, Jennifer Wo, Jeffrey Clark, David Ryan, Carlos Fernandez-del Castillo, Theodore Hong, Mikael Pittet, Sonu Subudhi

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3920e43d7c9e557e12ac07ea269b23
https://doi.org/10.1136/jitc-2022-sitc2022.1463

Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy

Autor: Sylvie Roberge, Kosuke Kawaguchi, Sampurna Chatterjee, Patrik Andersson, Peigen Huang, Meenal Datta, Vikash P. Chauhan, Ivy X. Chen, Nilesh Talele, William Ho, Shuichi Aoki, Zohreh Amoozgar, Igor L. Gomes-Santos, Jeffrey W. Clark, Dai Fukumura, Rakesh K. Jain, Mei Rosa Ng, Dan G. Duda, Mikael J. Pittet, Hao Liu, Ashwin S. Kumar, Qixian Zhang, Lei Xu, Jun Ren

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 45, pp. e2105323118

Significance Immune checkpoint blockade (ICB) has been efficacious in several cancer types. However, mismatch repair–proficient (pMMR) metastatic colorectal cancer (CRC), ∼95% of total metastatic CRC cases, typically does not respond to ICB. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34dfd58309599ca4aa4bddadd7c73c2
http://europepmc.org/articles/PMC8609309

AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth

Autor: Nilesh Talele, Albert C. Yeh, Ipsita Dey-Guha, Cleidson de Pádua Alves, Sheheryar Kabraji, Massimo Loda, Joeeta Chowdhury, Dennis C. Sgroi, Anne Lise Børresen-Dale, Kenneth N. Ross, Mari Mino-Kenudson, Hege G. Russnes, Sridhar Ramaswamy, Xavier Solé

Publikováno v: Molecular Cancer Therapeutics. 17:254-263

Human tumor growth depends on rapidly dividing cancer cells driving population expansion. Even advanced tumors, however, contain slowly proliferating cancer cells for reasons that remain unclear. Here, we selectively disrupt the ability of rapidly pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f0234b7543f8fac12cb1a5eb7829baf
https://doi.org/10.1158/1535-7163.mct-16-0868