Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nilesh Talele"'
Autor:
Rakesh Jain, Nilesh Talele, Heena Kumra, Igor Gomes Dos Santos, Sylvie Roberge, William Ho, Patrik Andersson, Sampurna Chatterjee, Marie Siwicki, Dan Duda, Mikael Pittet, Dai Fukumura
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46b3835ff0b1f19b48316e4e1fcad339
https://doi.org/10.1136/jitc-2022-sitc2022.1241
https://doi.org/10.1136/jitc-2022-sitc2022.1241
Autor:
Rakesh Jain, Yves Boucher, Jessica Posada, Spencer Rosario, Liqun Gu, Ashwin Kumar, Heena Kumra, Mari Mino-Kenudson, Nilesh Talele, Dan Duda, Dai Fukumura, Jennifer Wo, Jeffrey Clark, David Ryan, Carlos Fernandez-del Castillo, Theodore Hong, Mikael Pittet, Sonu Subudhi
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3920e43d7c9e557e12ac07ea269b23
https://doi.org/10.1136/jitc-2022-sitc2022.1463
https://doi.org/10.1136/jitc-2022-sitc2022.1463
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187348 (2017)
MSCs are widely applied to regenerate heart tissue in myocardial diseases but when grown in standard two-dimensional (2D) cultures exhibit limited potential for cardiac repair and develop fibrogenic features with increasing culture time. MSCs can und
Externí odkaz:
https://doaj.org/article/4512369891fe4b19ae67e81670c622a6
Autor:
Laila Ritsma, Ipsita Dey-Guha, Nilesh Talele, Xavier Sole, Salony, Joeeta Chowdhury, Kenneth N Ross, Sridhar Ramaswamy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175300 (2017)
TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironme
Externí odkaz:
https://doaj.org/article/928f5505a3db4d31bd3f4df0c416ec6c
Autor:
Nilesh Talele, Rakesh K. Jain, Kangsan Roh, Dai Fukumura, Zohreh Amoozgar, Hannah Curtis, Igor L. Gomes-Santos, Kosuke Kawaguchi, Ashwin S. Kumar, William Ho
Publikováno v:
Cancer Immunology Research. 9:765-778
The mechanisms behind the antitumor effects of exercise training (ExTr) are not fully understood. Using mouse models of established breast cancer, we examined here the causal role of CD8+ T cells in the benefit acquired from ExTr in tumor control, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ae57bd96f5efdb4098451fb0c68751
https://doi.org/10.1158/2326-6066.cir-20-0499
https://doi.org/10.1158/2326-6066.cir-20-0499
Autor:
Sylvie Roberge, Kosuke Kawaguchi, Sampurna Chatterjee, Patrik Andersson, Peigen Huang, Meenal Datta, Vikash P. Chauhan, Ivy X. Chen, Nilesh Talele, William Ho, Shuichi Aoki, Zohreh Amoozgar, Igor L. Gomes-Santos, Jeffrey W. Clark, Dai Fukumura, Rakesh K. Jain, Mei Rosa Ng, Dan G. Duda, Mikael J. Pittet, Hao Liu, Ashwin S. Kumar, Qixian Zhang, Lei Xu, Jun Ren
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 45, pp. e2105323118
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 45, pp. e2105323118
Significance Immune checkpoint blockade (ICB) has been efficacious in several cancer types. However, mismatch repair–proficient (pMMR) metastatic colorectal cancer (CRC), ∼95% of total metastatic CRC cases, typically does not respond to ICB. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34dfd58309599ca4aa4bddadd7c73c2
http://europepmc.org/articles/PMC8609309
http://europepmc.org/articles/PMC8609309
Autor:
Nicolas A. Gort-Freitas, Christina Pfirschke, Anna Kohl, Doron Merkler, Marie Siwicki, Yoshiko Iwamoto, Chiara Cianciaruso, Rapolas Zilionis, Marius Messemaker, Sara I. Pai, John E. Mindur, Montserrat Fraga, Pierre-Yves Dietrich, Angela E. Zou, Alexander Coukos, Christine Sempoux, Yi-Jang Lin, Nilesh Talele, Cecile Piot, Thibaud Koessler, Alexandre Wicky, Rakesh K. Jain, Yunkang Lin, Mikael J. Pittet, Rainer H. Kohler, Ruben Bill, Christopher Garris, Camilla Engblom, Jeremy Gungabeesoon, Allon M. Klein, Claudio deVito, Olivier Michielin, Ralph Weissleder, Evangelia Bolli, Genevieve M. Gerhard, Mari Mino-Kenudson
Publikováno v:
Sci Immunol
Science Immunology, Vol. 6, No 61 (2021) P. eabi7083
Science Immunology, Vol. 6, No 61 (2021) P. eabi7083
Immunotherapy is revolutionizing cancer treatment but is often restricted by toxicities. What distinguishes adverse events from concomitant antitumor reactions is poorly understood. Here, using anti-CD40-treatment in mice as a model of Th1-promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9db22b1b089ff465f17caa910096aa
https://doi.org/10.1126/sciimmunol.abi7083
https://doi.org/10.1126/sciimmunol.abi7083
Autor:
Carlos Fernandez-del Castillo, Yves Boucher, Dai Fukumura, Nilesh Talele, David P. Ryan, Jessica M. Posada, Rakesh K. Jain, Ivy X. Chen, Jeffrey W. Clark, Mei Rosa Ng, Mari Mino-Kenudson, Sonu Subudhi, Janet E. Murphy, Ashwin S. Kumar, Theodore S. Hong, Dan G. Duda
Publikováno v:
Cancer Research. 81:PO-097
Purpose: A phase II trial in patients with locally-advanced pancreatic cancer (LAPC) revealed unprecedented rates of complete surgical resection after adding losartan (L) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) (NCT01821729)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::381e46f6deca8f8c438e524efa70af2c
https://doi.org/10.1158/1538-7445.panca21-po-097
https://doi.org/10.1158/1538-7445.panca21-po-097
The mechanical environment modulates intracellular calcium oscillation activities of myofibroblasts.
Autor:
Charles Godbout, Lysianne Follonier Castella, Eric A Smith, Nilesh Talele, Melissa L Chow, Adriano Garonna, Boris Hinz
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64560 (2013)
Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.
Externí odkaz:
https://doaj.org/article/03c2ba9e5aa0423a9116f3fac6558e52
Autor:
Nilesh Talele, Albert C. Yeh, Ipsita Dey-Guha, Cleidson de Pádua Alves, Sheheryar Kabraji, Massimo Loda, Joeeta Chowdhury, Dennis C. Sgroi, Anne Lise Børresen-Dale, Kenneth N. Ross, Mari Mino-Kenudson, Hege G. Russnes, Sridhar Ramaswamy, Xavier Solé
Publikováno v:
Molecular Cancer Therapeutics. 17:254-263
Human tumor growth depends on rapidly dividing cancer cells driving population expansion. Even advanced tumors, however, contain slowly proliferating cancer cells for reasons that remain unclear. Here, we selectively disrupt the ability of rapidly pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0234b7543f8fac12cb1a5eb7829baf
https://doi.org/10.1158/1535-7163.mct-16-0868
https://doi.org/10.1158/1535-7163.mct-16-0868