Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nilesh Amatya"'
Autor:
Ankit Mahendra, Aftabul Haque, Ponraj Prabakaran, Brian C. Mackness, Thomas P. Fuller, Xiaohua Liu, Sagar V. Kathuria, Yui-Hsi Wang, Nilesh Amatya, Xiaocong Yu, Joern Hopke, Dietmar Hoffmann, Eva Bric-Furlong, Ningning Zhang, Hyun-Suk Cho, Ruijun Zhang, Jose Sancho, Jacqueline Saleh, Sambasiva P. Rao, Maria Wendt, Partha S. Chowdhury
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The authors developed a methodology for bulk enrichment of antigen-specific B cells to improve the diversity of antibody sequences and increase the number of functional antigen-specific antibodies coming from different antibody generation platforms.
Externí odkaz:
https://doaj.org/article/52ce13cfecd7433fa59e55c134afee54
Autor:
Rami Bechara, Nilesh Amatya, Saikat Majumder, Chunsheng Zhou, Yang Li, Qixing Liu, Mandy J. McGeachy, Sarah L. Gaffen
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the
Externí odkaz:
https://doaj.org/article/071c9084a6c34ebbb2a47971faa2c091
Autor:
Nandan S. Gokhale, Sarah L. Gaffen, Rami Bechara, Nilesh Amatya, Stacy M. Horner, Yang Li, Rachel D. Bailey, Bianca M. Coleman, Partha S. Biswas, Felix E. Y. Aggor, Chetan V. Jawale, Ning Dai, Anita Bansal, Tiffany C. Taylor, Amanda C. Poholek, De-Dong Li
Publikováno v:
Science Immunology. 6
Excessive cytokine activity underlies many autoimmune conditions, particularly through the interleukin-17 (IL-17) and tumor necrosis factor-α (TNFα) signaling axis. Both cytokines activate nuclear factor κB, but appropriate induction of downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e442551eb979d8552cfac874280490
https://doi.org/10.1126/sciimmunol.abd1287
https://doi.org/10.1126/sciimmunol.abd1287
IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival
Autor:
Natalie Rittenhouse, Shankar Revu, Saikat Majumder, Fang Du, Sarah L. Gaffen, Ashley V. Menk, Ulrich Siebenlist, Timothy W. Hand, Chetan V. Jawale, Dongwen Wu, Mandy J. McGeachy, Itay Raphael, Nilesh Amatya, Amanda C. Poholek, Greg M. Delgoffe, Saran Kupul, Partha S. Biswas, Amrita Bhattacharjee
Publikováno v:
Nature Immunology. 20:534-545
Lymph-node (LN) stromal cell populations expand during the inflammation that accompanies T cell activation. Interleukin-17 (IL-17)-producing helper T cells (TH17 cells) promote inflammation through the induction of cytokines and chemokines in periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12007f060c12a3360c009eb2df49332
https://doi.org/10.1038/s41590-019-0367-4
https://doi.org/10.1038/s41590-019-0367-4
Autor:
Rami, Bechara, Nilesh, Amatya, Rachel D, Bailey, Yang, Li, Felix E Y, Aggor, De-Dong, Li, Chetan V, Jawale, Bianca M, Coleman, Ning, Dai, Nandan S, Gokhale, Tiffany C, Taylor, Stacy M, Horner, Amanda C, Poholek, Anita, Bansal, Partha S, Biswas, Sarah L, Gaffen
Publikováno v:
Sci Immunol
Excessive cytokine activity underlies many autoimmune conditions, particularly through the IL-17 and TNFα signaling axes. Both cytokines activate NF-κB, but appropriate induction of downstream effector genes requires coordinated activation of other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97866a26698a56b15207a65324e939d8
https://pubmed.ncbi.nlm.nih.gov/34215679
https://pubmed.ncbi.nlm.nih.gov/34215679
Autor:
Brian J. Aneskievich, Rudi Beyaert, Sarah L. Gaffen, Lawrence P. Kane, Nilesh Amatya, Erin E. Childs, Abhishek V. Garg, J. Agustin Cruz, Averil Ma
Publikováno v:
IMMUNOHORIZONS
IL-17 activates NF-κB and induces expression of proinflammatory genes. IL-17 drives disease in autoimmune conditions, and anti–IL-17 Abs have shown impressive success in the clinic. Although produced by lymphocytes, IL-17 predominantly signals in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76153ff912543b8462d787c3f47bff12
https://doi.org/10.4049/immunohorizons.1700035
https://doi.org/10.4049/immunohorizons.1700035
Publikováno v:
Trends in Immunology. 38:310-322
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e1691e22fd5a06e38eaf4d59050658
https://doi.org/10.1016/j.it.2017.01.006
https://doi.org/10.1016/j.it.2017.01.006
Autor:
Eerin E. Childs, Nilesh Amatya, Sarah L. Gaffen, Abhishek V. Garg, Johann E. Gudjonsson, Bianca M. Coleman, Nicole L. Ward, Akash H. Verma, Alicia R. Mathers, Leticia Monin, Xianying Xing, Meaghan E. Killeen
Publikováno v:
The Journal of Immunology. 198:767-775
The IL-17 family cytokines IL-17A and IL-17C drive the pathogenesis of psoriatic skin inflammation, and anti–IL-17A Abs were recently approved to treat human psoriasis. Little is known about mechanisms that restrain IL-17 cytokine-mediated signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709a44bebdce451ad941355e34c4acc6
https://doi.org/10.4049/jimmunol.1601551
https://doi.org/10.4049/jimmunol.1601551
Autor:
Rami Bechara, Nilesh Amatya, Rachel D. Bailey, Yang Li, Felix EY Aggor, De-Dong Li, Chetan V. Jawale, Bianca M. Coleman, Ning Dai, Nandan S. Gokhale, Tiffany C. Taylor, Stacy M. Horner, Amanda C. Poholek, Partha S. Biswas, Sarah L. Gaffen
Publikováno v:
The Journal of Immunology. 206:22.06-22.06
Dysregulated activity of IL-17 underlies many autoimmune conditions, but the molecular mechanisms by which IL-17 mediates pathogenic inflammation remain poorly understood. IL-17 regulates pathogenic inflammatory genes by two key transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09da5d17c638187a91e7f6ea32c93e5
https://doi.org/10.4049/jimmunol.206.supp.22.06
https://doi.org/10.4049/jimmunol.206.supp.22.06
Autor:
Andrea J. Berman, Nilesh Amatya, Felix E. Y. Aggor, Ulus Atasoy, Erin E. Childs, Abhishek V. Garg, Johann E. Gudjonsson, Sarah L. Gaffen, J. Agustin Cruz
Publikováno v:
Science signaling. 11(551)
Interleukin-17A (IL-17A) not only stimulates immunity to fungal pathogens but also contributes to autoimmune pathology. IL-17 is only a modest activator of transcription in experimental tissue culture settings. However, IL-17 controls posttranscripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cc4f35b90fb299899ef979b8eb30a1
https://pubmed.ncbi.nlm.nih.gov/30301789
https://pubmed.ncbi.nlm.nih.gov/30301789