Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nileena Velappan"'
Autor:
Nileena Velappan, Fortunato Ferrara, Sara D'Angelo, Devin Close, Leslie Naranjo, Madeline R Bolding, Sarah C Mozden, Camille B Troup, Donna K McCullough, Analyssa Gomez, Marijo Kedge, Andrew R M Bradbury
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0280930 (2023)
Antibodies are important reagents for research, diagnostics, and therapeutics. Many examples of chimeric proteins combining the specific target recognition of antibodies with complementing functionalities such as fluorescence, toxicity or enzymatic a
Externí odkaz:
https://doaj.org/article/11a2f16525564b46ab218f4b5b96ed0c
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Black swan events in infectious disease describe rare but devastatingly large outbreaks. While experts are skeptical that such events are predictable, it might be possible to identify the warning signs of a black swan event. Specifically, following t
Externí odkaz:
https://doaj.org/article/3a3eaa3042fa4066b6fe2b7e566a4ac0
Autor:
Nileena Velappan, Avanika Mahajan, Leslie Naranjo, Priyanka Velappan, Nasim Andrews, Nicholas Tiee, Subhendu Chakraborti, Colin Hemez, Tiziano Gaiotto, Bridget Wilson, Andrew Bradbury
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1206-1218 (2019)
Post-translational modifications, such as the phosphorylation of tyrosines, are often the initiation step for intracellular signaling cascades. Pan-reactive antibodies against modified amino acids (e.g., anti-phosphotyrosine), which are often used to
Externí odkaz:
https://doaj.org/article/10edd85e6c9b4e6fb382d9d01fc06caf
Autor:
Sofiya N. Micheva-Viteva, Migun Shakya, Samantha H. Adikari, Cheryl D. Gleasner, Nileena Velappan, Judith R. Mourant, Patrick S. G. Chain, Elizabeth Hong-Geller
Publikováno v:
mSystems, Vol 5, Iss 1 (2020)
ABSTRACT Persister cells are genetically identical variants in a bacterial population that have phenotypically modified their physiology to survive environmental stress. In bacterial pathogens, persisters are able to survive antibiotic treatment and
Externí odkaz:
https://doaj.org/article/4a82266cfc2b4f6889f308fa00fb1b73
Autor:
Nileena Velappan, Sofiya Micheva-Viteva, Samantha H. Adikari, Geoffrey S. Waldo, Antonietta M. Lillo, Andrew R.M. Bradbury
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Interactions between the cytoplasmic domains of viral transmembrane proteins and host machinery often determine the outcome of viral infection. The M2 protein of influenza A has been identified as a key player in autophagy-mediated viral replication.
Externí odkaz:
https://doaj.org/article/bfd2f03c531744d29fb275e897d72607
Autor:
Ashlynn R. Daughton, Reid Priedhorsky, Geoffrey Fairchild, Nicholas Generous, Andrea Hengartner, Esteban Abeyta, Nileena Velappan, Antonietta Lillo, Karen Stark, Alina Deshpande
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Biosurveillance, a relatively young field, has recently increased in importance because of increasing emphasis on global health. Databases and tools describing particular subsets of disease are becoming increasingly common in the field. Here
Externí odkaz:
https://doaj.org/article/0973a2ff5cc24421ba010a6da4b119c6
Autor:
Geoffrey Fairchild, Byron Tasseff, Hari Khalsa, Nicholas Generous, Ashlynn R. Daughton, Nileena Velappan, Reid Priedhorsky, Alina Deshpande
Publikováno v:
Frontiers in Public Health, Vol 6 (2018)
Accessible epidemiological data are of great value for emergency preparedness and response, understanding disease progression through a population, and building statistical and mechanistic disease models that enable forecasting. The status quo, howev
Externí odkaz:
https://doaj.org/article/77604969bd42446b90acfe0e41e6c193
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158330 (2016)
Influenza causes significant morbidity and mortality each year, with 2-8% of weekly outpatient visits around the United States for influenza-like-illness (ILI) during the peak of the season. Effective use of existing flu surveillance data allows offi
Externí odkaz:
https://doaj.org/article/9942411b78ba4b86b00aa24286b41863
Autor:
Nileena Velappan, Hau B. Nguyen, Sofiya Micheva-Viteva, Daniel Bedinger, Chunyan Ye, Betty Mangadu, Austin J. Watts, Robert Meagher, Steven Bradfute, Bin Hu, Geoffrey S. Waldo, Antonietta M. Lillo
Publikováno v:
Bioengineered. 13:12598-12624
Here, we describe the isolation of 18 unique anti SARS-CoV-2 human single-chain antibodies from an antibody library derived from healthy donors. The selection used a combination of phage and yeast display technologies and included counter-selection s
Autor:
Tisza A. S. Bell, Nileena Velappan, Cheryl D. Gleasner, Gang Xie, Shawn R. Starkenburg, Geoffrey Waldo, Shounak Banerjee, Sofiya N. Micheva‐Viteva
Publikováno v:
Molecular microbiology. 117(2)
Autophagy is a critical mechanism deployed by eukaryotic cells in response to stress, including viral infection, to boost the innate antimicrobial responses. However, an increasing number of pathogens hijack the autophagic machinery to facilitate the